The Influence of Epinephrine and Phenylephrine on Intraocular Pressure

Guanethidine ? adrenaline eye drops in glaucoma simplex

“…Since, barring case 3, the pupils of the eyes treated with GA dilated during the first few hours following administration. Lee (1958) reported an occasional prolonged and significant increase in IOP in open angle glaucoma patients following topical administration of adrenaline 1% or phenylephrine 10%. Figure 5, and tables 1 and 2 present the data of the average IOP daycurve and the average pupil size of the 12 treated eyes and untreated fellow eyes.…”

Guanethidine ? adrenaline eye drops in glaucoma simplex

“…Since, barring case 3, the pupils of the eyes treated with GA dilated during the first few hours following administration. Lee (1958) reported an occasional prolonged and significant increase in IOP in open angle glaucoma patients following topical administration of adrenaline 1% or phenylephrine 10%. Figure 5, and tables 1 and 2 present the data of the average IOP daycurve and the average pupil size of the 12 treated eyes and untreated fellow eyes.…”

Effect of Topical Phenylephrine 2.5% on Episcleral Venous Pressure in Normal Human Eyes

“…Other studies have reported a slight increase in IOP after phenylephrine treatment. 12 – 17 In contrast, Becker 6 reported that phenylephrine caused a mild IOP reduction in both normal eyes and eyes with open-angle glaucoma. One possible reason for the variety of results may be due to individual patient variations.…”

“…However, the effect of phenylephrine on IOP is inconclusive in the literature. Several studies have indicated no change in IOP in normal eyes 8 – 12 , 48 or in eyes with open-angle glaucoma 10 , 12 after treatment with phenylephrine. Other studies have reported a slight increase in IOP after phenylephrine treatment.…”

Administration of Bicarbonate Protects Mitochondria, Rescues Retinal Ganglion Cells, and Ameliorates Visual Dysfunction Caused by Oxidative Stress

“…As a cellular energy sensor, AMPK is a critical guardian and regulator of metabolic activity that controls normal energy homeostasis [ 52 , 53 ] and has a role in mitochondrial fission under energy stress [ 54 ]. sAC is involved in regulating AMPK activity, maintaining mitochondrial function, cellular redox balance, and energy homeostasis [ 38 ].…”

Guanethidine ? adrenaline eye drops in glaucoma simplex

“…Since, barring case 3, the pupils of the eyes treated with GA dilated during the first few hours following administration. Lee (1958) reported an occasional prolonged and significant increase in IOP in open angle glaucoma patients following topical administration of adrenaline 1% or phenylephrine 10%. Figure 5, and tables 1 and 2 present the data of the average IOP daycurve and the average pupil size of the 12 treated eyes and untreated fellow eyes.…”

Effect of Topical Phenylephrine 2.5% on Episcleral Venous Pressure in Normal Human Eyes

“…Other studies have reported a slight increase in IOP after phenylephrine treatment. 12 – 17 In contrast, Becker 6 reported that phenylephrine caused a mild IOP reduction in both normal eyes and eyes with open-angle glaucoma. One possible reason for the variety of results may be due to individual patient variations.…”

“…However, the effect of phenylephrine on IOP is inconclusive in the literature. Several studies have indicated no change in IOP in normal eyes 8 – 12 , 48 or in eyes with open-angle glaucoma 10 , 12 after treatment with phenylephrine. Other studies have reported a slight increase in IOP after phenylephrine treatment.…”

Administration of Bicarbonate Protects Mitochondria, Rescues Retinal Ganglion Cells, and Ameliorates Visual Dysfunction Caused by Oxidative Stress

“…As a cellular energy sensor, AMPK is a critical guardian and regulator of metabolic activity that controls normal energy homeostasis [ 52 , 53 ] and has a role in mitochondrial fission under energy stress [ 54 ]. sAC is involved in regulating AMPK activity, maintaining mitochondrial function, cellular redox balance, and energy homeostasis [ 38 ].…”

Guanethidine ? adrenaline eye drops in glaucoma simplex

“…Since, barring case 3, the pupils of the eyes treated with GA dilated during the first few hours following administration. Lee (1958) reported an occasional prolonged and significant increase in IOP in open angle glaucoma patients following topical administration of adrenaline 1% or phenylephrine 10%. Figure 5, and tables 1 and 2 present the data of the average IOP daycurve and the average pupil size of the 12 treated eyes and untreated fellow eyes.…”

Effect of Topical Phenylephrine 2.5% on Episcleral Venous Pressure in Normal Human Eyes

“…Other studies have reported a slight increase in IOP after phenylephrine treatment. 12 – 17 In contrast, Becker 6 reported that phenylephrine caused a mild IOP reduction in both normal eyes and eyes with open-angle glaucoma. One possible reason for the variety of results may be due to individual patient variations.…”

“…However, the effect of phenylephrine on IOP is inconclusive in the literature. Several studies have indicated no change in IOP in normal eyes 8 – 12 , 48 or in eyes with open-angle glaucoma 10 , 12 after treatment with phenylephrine. Other studies have reported a slight increase in IOP after phenylephrine treatment.…”

Administration of Bicarbonate Protects Mitochondria, Rescues Retinal Ganglion Cells, and Ameliorates Visual Dysfunction Caused by Oxidative Stress

“…As a cellular energy sensor, AMPK is a critical guardian and regulator of metabolic activity that controls normal energy homeostasis [ 52 , 53 ] and has a role in mitochondrial fission under energy stress [ 54 ]. sAC is involved in regulating AMPK activity, maintaining mitochondrial function, cellular redox balance, and energy homeostasis [ 38 ].…”