The influence of dietary phosphate on the toxicity of orally ingested lead in rats

Assessment of Lead Ecotoxicity in Water using the Amphibian Larvae (Xenopus laevis) and Preliminary Study of its Immobilization in Meat and Bone Meal Combustion Residues

“…Meredith et al (1977), Bogden et al (1992) and more recently Varnai et al (2001) also showed that higher Ca intake might be a way of reducing Pb absorption in rats. In the same way, Quaterman et al (1978), Spickett and Bell (1983) and more recently Cortina-Ramirez et al (2005) also showed that increased dietary phosphate limits Pb intestinal absorption in rats. It may be due to the Ca-Pb competition for the protein Ca transporters in the intestinal lumen (Edelstein et al 1984;Fullmer 1997) and probably to formation of the phosphate-Pb complex, which makes the intestinal absorption of Pb difficult (Mikkanen et al 1984).…”

Assessment of Lead Ecotoxicity in Water using the Amphibian Larvae (Xenopus laevis) and Preliminary Study of its Immobilization in Meat and Bone Meal Combustion Residues

“…Meredith et al (1977), Bogden et al (1992) and more recently Varnai et al (2001) also showed that higher Ca intake might be a way of reducing Pb absorption in rats. In the same way, Quaterman et al (1978), Spickett and Bell (1983) and more recently Cortina-Ramirez et al (2005) also showed that increased dietary phosphate limits Pb intestinal absorption in rats. It may be due to the Ca-Pb competition for the protein Ca transporters in the intestinal lumen (Edelstein et al 1984;Fullmer 1997) and probably to formation of the phosphate-Pb complex, which makes the intestinal absorption of Pb difficult (Mikkanen et al 1984).…”

The influence of dietary citrate on the absorption and retention of orally ingested lead

“…Work on the effect of chelating agents by Ju6o, MO~KOVlC and KOSTIAL [3], utilizing short term exposure to radioactive lead coneluded that citrate increased the whole body retention of orally ingested lead. Although occasional cases of lead poisoning still occur, an increasing amount of concern has been given to continual exposure to lower levels of lead in the environment.…”

Dietary Lead and Phosphate Interactions Affect Oral Bioavailability of Soil Lead in the Mouse

“…Variation in dietary P level has been shown to affect the uptake and systemic kinetics of ingested soluble Pb compounds. In rats consuming a Pb-amended diet, lower dietary P levels increased tissue levels of orally administered Pb; in contrast, higher dietary P levels reduced tissue levels of orally administered Pb , and reduced the toxicity of ingested Pb . Effects of dietary P on the kinetic and dynamic behavior of ingested Pb have generally been considered in terms of formation of poorly soluble Pb–P complexes.…”

“…In rats consuming a Pb-amended diet, lower dietary P levels increased tissue levels of orally administered Pb; in contrast, higher dietary P levels reduced tissue levels of orally administered Pb 14,15 and reduced the toxicity of ingested Pb. 16 Effects of dietary P on the kinetic and dynamic behavior of ingested Pb have generally been considered in terms of formation of poorly soluble Pb−P complexes. The role of P in control of solubility of Pb has been examined in both aqueous environments and in soils.…”

Assessment of Lead Ecotoxicity in Water using the Amphibian Larvae (Xenopus laevis) and Preliminary Study of its Immobilization in Meat and Bone Meal Combustion Residues

“…Meredith et al (1977), Bogden et al (1992) and more recently Varnai et al (2001) also showed that higher Ca intake might be a way of reducing Pb absorption in rats. In the same way, Quaterman et al (1978), Spickett and Bell (1983) and more recently Cortina-Ramirez et al (2005) also showed that increased dietary phosphate limits Pb intestinal absorption in rats. It may be due to the Ca-Pb competition for the protein Ca transporters in the intestinal lumen (Edelstein et al 1984;Fullmer 1997) and probably to formation of the phosphate-Pb complex, which makes the intestinal absorption of Pb difficult (Mikkanen et al 1984).…”

The influence of dietary citrate on the absorption and retention of orally ingested lead

“…Work on the effect of chelating agents by Ju6o, MO~KOVlC and KOSTIAL [3], utilizing short term exposure to radioactive lead coneluded that citrate increased the whole body retention of orally ingested lead. Although occasional cases of lead poisoning still occur, an increasing amount of concern has been given to continual exposure to lower levels of lead in the environment.…”

Dietary Lead and Phosphate Interactions Affect Oral Bioavailability of Soil Lead in the Mouse

“…Variation in dietary P level has been shown to affect the uptake and systemic kinetics of ingested soluble Pb compounds. In rats consuming a Pb-amended diet, lower dietary P levels increased tissue levels of orally administered Pb; in contrast, higher dietary P levels reduced tissue levels of orally administered Pb , and reduced the toxicity of ingested Pb . Effects of dietary P on the kinetic and dynamic behavior of ingested Pb have generally been considered in terms of formation of poorly soluble Pb–P complexes.…”

“…In rats consuming a Pb-amended diet, lower dietary P levels increased tissue levels of orally administered Pb; in contrast, higher dietary P levels reduced tissue levels of orally administered Pb 14,15 and reduced the toxicity of ingested Pb. 16 Effects of dietary P on the kinetic and dynamic behavior of ingested Pb have generally been considered in terms of formation of poorly soluble Pb−P complexes. The role of P in control of solubility of Pb has been examined in both aqueous environments and in soils.…”

Assessment of Lead Ecotoxicity in Water using the Amphibian Larvae (Xenopus laevis) and Preliminary Study of its Immobilization in Meat and Bone Meal Combustion Residues

“…Meredith et al (1977), Bogden et al (1992) and more recently Varnai et al (2001) also showed that higher Ca intake might be a way of reducing Pb absorption in rats. In the same way, Quaterman et al (1978), Spickett and Bell (1983) and more recently Cortina-Ramirez et al (2005) also showed that increased dietary phosphate limits Pb intestinal absorption in rats. It may be due to the Ca-Pb competition for the protein Ca transporters in the intestinal lumen (Edelstein et al 1984;Fullmer 1997) and probably to formation of the phosphate-Pb complex, which makes the intestinal absorption of Pb difficult (Mikkanen et al 1984).…”

The influence of dietary citrate on the absorption and retention of orally ingested lead

“…Work on the effect of chelating agents by Ju6o, MO~KOVlC and KOSTIAL [3], utilizing short term exposure to radioactive lead coneluded that citrate increased the whole body retention of orally ingested lead. Although occasional cases of lead poisoning still occur, an increasing amount of concern has been given to continual exposure to lower levels of lead in the environment.…”

Dietary Lead and Phosphate Interactions Affect Oral Bioavailability of Soil Lead in the Mouse

“…Variation in dietary P level has been shown to affect the uptake and systemic kinetics of ingested soluble Pb compounds. In rats consuming a Pb-amended diet, lower dietary P levels increased tissue levels of orally administered Pb; in contrast, higher dietary P levels reduced tissue levels of orally administered Pb , and reduced the toxicity of ingested Pb . Effects of dietary P on the kinetic and dynamic behavior of ingested Pb have generally been considered in terms of formation of poorly soluble Pb–P complexes.…”

“…In rats consuming a Pb-amended diet, lower dietary P levels increased tissue levels of orally administered Pb; in contrast, higher dietary P levels reduced tissue levels of orally administered Pb 14,15 and reduced the toxicity of ingested Pb. 16 Effects of dietary P on the kinetic and dynamic behavior of ingested Pb have generally been considered in terms of formation of poorly soluble Pb−P complexes. The role of P in control of solubility of Pb has been examined in both aqueous environments and in soils.…”