The influence of composition on the physical properties of PLA-PEG-PLA-co-Boltorn based polyester hydrogels and their biological performance

Wang, David; Varanasi, Srinivas; Hill, David J. T.; Rasoul, Firas; Symons, A. L.; Whittaker, Andrew K.

doi:10.1039/c2jm00039c

Cited by 15 publications

(27 citation statements)

References 29 publications

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“…Reul et al reported that the degradation of Boltorn ® H40 (a fourth generation polyester modified with tertiary amines) was shown to proceed via ester hydrolysis of the Boltorn core in phosphate‐buffered saline (PBS). Our previous work on PEG‐based and PLA‐PEG‐PLA‐based hydrogels with the systematic incorporation of a Boltorn vinyl macromonomer (see BH20PEGA in Fig. ) demonstrated enhanced swelling and degradation profiles in aqueous media compared with their pure polymeric counterparts.…”

Section: Introductionmentioning

confidence: 96%

“…) demonstrated enhanced swelling and degradation profiles in aqueous media compared with their pure polymeric counterparts. It was shown previously that incorporating BH20PEGA in both of these hydrogel systems enhances network degradation due to the greater swelling of these hydrogels, which facilitates hydrolysis of the ester groups in PBS (pH 7.4) at 37 °C …”

Section: Introductionmentioning

confidence: 98%

“…Earlier studies by others have demonstrated that Boltorn copolymers are not cytotoxic. In addition, we have reported that crosslinked hydrogels incorporating the Boltorn macromonomer and diacrylated poly(lactic acid‐ b ‐ethylene glycol‐ b ‐lactic acid) are cytocompatible . The study of the proliferation and viability of the periodontal fibroblasts demonstrated that these hydrogels performed significantly better than the tissue culture plates used as the control over a 5‐day test period.…”

Section: Introductionmentioning

confidence: 99%

“…In the work described herein, we have investigated the degradation properties of the hydrogels and the cytocompatibility of a representative example of the BH20 hydrogel series formed by polymerizing the Boltorn macromonomer and diacrylated ABA triblock copolymers . These crosslinked copolymer networks contain diacrylated ABA triblock copolymers (PLA a PEG b PLA a DA) with between 2.5 and 10 units in the PLA block and with 20 or 41 units in the PEG block.…”

Section: Introductionmentioning

confidence: 99%

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FT-IR characterization and hydrolysis of PLA-PEG-PLA based copolyester hydrogels with short PLA segments and a cytocompatibility study

Wang

Varanasi

Fredericks

et al. 2013

J. Polym. Sci. Part A: Polym. Chem.

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Telephone: + 61 7 334 63860; Facsimile: + 61 7 334 60330 Keywords 2 Structure-property relations, hydrolytic degradation, infrared spectroscopy, in-vitro cytocompatibility, poly(PEG-co-lactide) hydrogel AbstractA series of the biodegradable copolyester hydrogels was prepared using a redoxinitiated polymerization with a constant 1:9 mole ratio of the Boltorn-based acrylate and diacrylate triblock comacromonomers. The Boltorn® macromonomer was derived from the hyperbranched polyester Boltorn H20, which was functionalized at each terminus with poly(ethylene glycol) acrylate, and the diacrylate triblock macromonomer was poly(lactide-b-ethylene glycol-b-lactide) diacrylate. The hydrolysis of the copolyesters at pH 7.4 in a phosphate buffered saline solution at 37 °C was studied using ATR-FTIR spectroscopy. It was found that the presence of the Boltorn, the PEG and lactide block lengths both play vital roles in determining the structure-property relationships in these materials. The ATR-FTIR studies showed that with increasing lactide segment length, the rate of ester hydrolysis increased due to the increased concentration of the hydrolytically-sensitive PLA ester groups in the network. However, incorporation of Boltorn into the PLA-PEG-PLA copolymer did not significantly change the kinetic rate constant for hydrolysis of the PLA segments.The cytocompatibility of a typical one of these materials in the presence of its degradation by-products was assessed using cultured osteoblasts from the rat. The hydrogel was degraded for 28 days and found to be cytocompatible with osteoblasts over days 23 to 28 of the hydrolysis period.

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Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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FT-IR characterization and hydrolysis of PLA-PEG-PLA based copolyester hydrogels with short PLA segments and a cytocompatibility study

Wang

Varanasi

Fredericks

et al. 2013

J. Polym. Sci. Part A: Polym. Chem.

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“…These examples strongly support the versatility of PLA‐PEG block copolymers as biomedical materials. Recently, Wang et al copolymerized a terminal‐acrylated PLA‐PEG‐PLA with acrylated Boltorn‐PEG (BH20PEGA, Scheme (b)) . The hydrogels resulting from this copolymer showed enhanced swelling and thus enhanced in vitro degradation profiles in phosphate‐buffered saline (pH 7.4) at 37 °C compared to hydrogels based on the triblock copolymers alone.…”

Section: Specialty Pla Copolymers By Controlled Copolymerizationmentioning

confidence: 99%

Macromolecular design of specialty polylactides by means of controlled copolymerization and stereocomplexation

Masutani

Kimura

2016

Polymer International

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Among the bio-based polymers thus developed, poly-L-lactide (PLLA) has been the most widely used in many fields because of its excellent cost-property balance.However, the properties and functionalities of PLLA cannot easily be controlled as the conventional petroleum-based polymers, retarding the progress of its manufacturing in large scale. One approach to obtain high-performance and specialty polylactides is to use stereocomplex-type polylactides (sc-PLA) that can be obtained by mixing PLLA and its enantiomer poly-D-lactide (PDLA). The other approach is to use copolymers consisting of polylactides (PLA) and other types of macromolecular chains. Here we demonstrate how such high-performance and specialty PLA polymers can be designed and synthesized. These macromolecular designs and synthetic methodologies are This article is protected by copyright. All rights reserved.This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/pi.5172 Accepted Articlehighly effective for controlling the structure and properties of the PLA polymers for use as biomedical and high-end industrial materials.Key words: polylactides, stereoblock, polymer blend, copolymerization, surface immobilization 1) IntroductionPolymeric materials prepared from renewable natural resources are now being accepted as ''bio-based polymers''. These polymers are characterized by the new processing method called ''white biotechnology'' where bio-engineering using fermentation and plant biotechnology is focused as the principal technology. It is evident that the bio-synthesis of a number of key monomers (so-called platform chemicals) such as succinic and 2,5-furandicarboxylic acids has been progressing quite rapidly. Even terephthalic and adipic acids may possibly be replaced by the ones synthesized from these bio-based monomers and chemicals. This article is protected by copyright. All rights reserved. Accepted ArticleOther biomass-originated polyamides such as Nylon 11, polyesters such as poly(ethylene furanoate) (PEF), and isosorbide-based polycarbonate (Is-PC) will also be manufactured in large scale very soon. Some of these biobased polymers were once developed as biodegradable polymers that can be broken down into environmentally friendly substances by composting. However, their application was limited to temporal use at low cost, and their market has not become large enough. For replacing structural materials made of oil-based polymers, high-performance bio-based polymers ought to be developed because toughness and durability are needed for these applications.Among the bio-based polymers mentioned above, PLLA has taken a special position because of its balanced properties and cost performance. It can readily be prepared by ring-opening polymerization (ROP) of L-lactide monomer synthesized from L-lactic acid, a fe...

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Biodegradable and adjustable sol-gel glass based hybrid scaffolds from multi-armed oligomeric building blocks

et al. 2017

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The influence of composition on the physical properties of PLA-PEG-PLA-co-Boltorn based polyester hydrogels and their biological performance

Cited by 15 publications

References 29 publications

FT-IR characterization and hydrolysis of PLA-PEG-PLA based copolyester hydrogels with short PLA segments and a cytocompatibility study

FT-IR characterization and hydrolysis of PLA-PEG-PLA based copolyester hydrogels with short PLA segments and a cytocompatibility study

Macromolecular design of specialty polylactides by means of controlled copolymerization and stereocomplexation

Biodegradable and adjustable sol-gel glass based hybrid scaffolds from multi-armed oligomeric building blocks

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