The influence of chromosome 4 on metabolism and spatial memory in SHR and SLA16 rat strains

Velázquez, Ana Magdalena; Roversi, Katiane; Dillenburg-Pilla, Patrícia; Rodrigues, Raphaela Farias; Zárate-Bladés, Carlos R.; Prediger, Rui Daniel; Izídio, Geison S.

doi:10.1016/j.bbr.2019.111966

Cited by 4 publications

(2 citation statements)

References 63 publications

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“…While further studies need to be conducted to investigate this in the SHR, the data suggest that select catecholaminergic networks in the NTS may present a functional link between the gut, vagus, and BP. The reported role of the vagus in feeding and metabolism as well as in memory formation ( 30 ) is noteworthy, as is the reported deregulation in metabolism and learning and memory in the SHR ( 34 , 35 ), suggesting that GI vagal dysfunction may present one possible mechanistic connection between HTN and obesity. We did not investigate metabolic paradigms in the present study, and while we observed no weight differences between sham and stimulated SHRs at endpoint, future studies should fully investigate metabolic parameters and their connection to HTN in more detail.…”

Section: Discussionmentioning

confidence: 98%

Subdiaphragmatic vagal nerve stimulation attenuates the development of hypertension and alters nucleus of the solitary tract transcriptional networks in the spontaneously hypertensive rat

Dirr,

Jiracek,

Baekey

et al. 2023

Physiological Genomics

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Augmented vagal signaling may be therapeutic in hypertension. Most studies to date employed stimulation of the cervical vagal branches. Here, we investigated the effects of chronic intermittent electric stimulation of the ventral subdiaphragmatic vagal nerve branch (sdVNS) on long term blood pressure (BP), immune markers, and gut microbiota in the spontaneously hypertensive rat (SHR), a rodent model of hypertension characterized by vagal dysfunction, gut dysbiosis and low-grade inflammation. We evaluated the effects of sdVNS on transcriptional networks in the nucleus of the solitary tract (NTS), a major cardioregulatory brain region with direct gut vagal projections. Male juvenile SHR were implanted with radiotelemetry transmitters and vagal nerve cuffs for chronic intermittent electric sdVNS, applied three times per day for seven consecutive weeks followed by one week of no stimulation. BP was measured once a week using telemetry in the sdVNS group as well as the age-matched Sham-stimulated SHR controls. At endpoint, colonic and circulating inflammatory markers and corticosterone, and circulating catecholamines were investigated. Bacterial 16s sequencing measured gut bacterial abundance and composition. RNAseq evaluated the effects of sdVNS on transcriptional networks in the NTS. SHRs that received sdVNS exhibited attenuated development of hypertension compared to the Sham. No changes in peripheral inflammatory markers, corticosterone or catecholamines, and no major differences in gut bacterial diversity and composition were observed following sdVNS, apart from decreased abundance of Defluviitaleaceale bacterium detected in the sdVNS SHR compared to the Sham. RNAseq revealed significant sdVNS-dependent modulation of select NTS transcriptional networks, including catecholaminergic and corticosteroid networks.

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Section: Discussionmentioning

confidence: 98%

Subdiaphragmatic vagal nerve stimulation attenuates the development of hypertension and alters nucleus of the solitary tract transcriptional networks in the spontaneously hypertensive rat

Dirr,

Jiracek,

Baekey

et al. 2023

Physiological Genomics

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“…Velazquez et al . [ 69 ] also evaluated SLA16 and SHR rats in a series of emotionality, memory and learning behavioral tests, as well as in biochemical essays to assess metabolic functions. Their report confirmed that Anxrr16 exerts an influence on emotionality, memory and learning.…”

Section: The Sla16 Congenic Strainmentioning

confidence: 99%

Hunting for Genes Underlying Emotionality in the Laboratory Rat: Maps, Tools and Traps

Ramos

Granzotto

Kremer

et al. 2023

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Scientists have systematically investigated the hereditary bases of behaviors since the 19th century, moved by either evolutionary questions or clinically-motivated purposes. The pioneer studies on genetic selection of laboratory animals had already indicated, one hundred years ago, the immense complexity of analyzing behaviors that were influenced by a large number of small-effect genes and an incalculable amount of environmental factors. Merging Mendelian, quantitative and molecular approaches in the 1990s made it possible to map specific rodent behaviors to known chromosome regions. From that point on, Quantitative Trait Locus (QTL) analyses coupled with behavioral and molecular techniques, which involved in vivo isolation of relevant blocks of genes, opened new avenues for gene mapping and characterization. This review aims at examining the QTL strategy applied to the behavioral study of emotionality, with a focus on the laboratory rat. We discuss challenges, advances and limitations of the search for Quantitative Trait Genes (QTG) playing a role in the regulation of emotionality. For the past 25 years, we have marched the long journey from emotionality-related behaviors to genes. In this context, our experiences are used to illustrate why and how one should move forward in the molecular understanding of complex psychiatric illnesses. The promises of exploring genetic links between immunological and emotional responses are also discussed. New strategies based on humans, rodents and other animals (such as zebrafish) are also acknowledged, as they are likely to allow substantial progress to be made in the near future.

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Genetic effects in a progressive model of parkinsonism induced by reserpine

et al. 2023

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The influence of chromosome 4 on metabolism and spatial memory in SHR and SLA16 rat strains

Cited by 4 publications

References 63 publications

Subdiaphragmatic vagal nerve stimulation attenuates the development of hypertension and alters nucleus of the solitary tract transcriptional networks in the spontaneously hypertensive rat

Subdiaphragmatic vagal nerve stimulation attenuates the development of hypertension and alters nucleus of the solitary tract transcriptional networks in the spontaneously hypertensive rat

Hunting for Genes Underlying Emotionality in the Laboratory Rat: Maps, Tools and Traps

Genetic effects in a progressive model of parkinsonism induced by reserpine

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