The influence of caffeine on the biomechanical properties of bone tissue during pregnancy in a population of rats

Olchowik, Grażyna; Chadaj-Polberg, Emilia; Tomaszewski, Marek; Polberg, Mateusz; Tomaszewska, Monika

doi:10.5603/fhc.2011.0071

Cited by 22 publications

(32 citation statements)

References 26 publications

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“…Caffeine intake is negatively associated with gestational changes in animals, such as lower rates of fertilization and embryonic implantation, low birth and placental weight, greater number of stillbirths, increased expression of apoptotic markers and altered placental and bone formation [9,27,[40][41][42][43][44][45][46] ( Table 1).…”

Section: Caffeine and Pregnancymentioning

confidence: 99%

“…Olchowik and colleagues [45] reported that 30 mg/day of caffeine intake during pregnancy had negative influence in female rats' bone tissue. Tomaszewski and colleagues [41], using X-ray microprobe to examine female rats fetuses treated with 30 mg/day of caffeine, observed that the decreased bone mineralization was dominant in the treated group.…”

Section: Caffeine Intake During Pregnancy: What Are the Real Evidences?mentioning

confidence: 99%

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Caffeine Intake during Pregnancy: What Are the Real Evidences?

Paula¹,

Shang²,

Chiarini‐Garcia³

et al. 2017

JPP

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Abstract:Caffeine is a substance presented in foods such as coffee, tea, soft drinks, chocolates and medicines and is commonly consumed by pregnant women. Due to its ability to cross the placental membrane and accumulate in the fetus body, caffeine and its metabolites have been contraindicated or recommended in small doses during pregnancy. Studies in rodents relate caffeine intake to lower rates of fertilization, embryonic implantation, changes in placental structure, increased occurrence of low fetal and placental weights, abortion and stillbirth. However, in humans, studies involving caffeine consumption are inconclusive. Methodological complexity, difficulty for measuring caffeine intake and ethical reasons are limiting factors for a more accurate conclusion. So far, caffeine recommendation ranges from 100 to 300 mg/day. Even though researches have recommended low caffeine consumption by pregnant women in order to avoid deleterious consequences during gestation, a safe dose has not been established until now. The aim of the present review is to describe the main findings on the effects of caffeine consumption during pregnancy in both human and rodent experimental models.

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Section: Caffeine and Pregnancymentioning

confidence: 99%

Section: Caffeine Intake During Pregnancy: What Are the Real Evidences?mentioning

confidence: 99%

Caffeine Intake during Pregnancy: What Are the Real Evidences?

Paula¹,

Shang²,

Chiarini‐Garcia³

et al. 2017

JPP

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“…Since then, a number of studies have confirmed the negative effect of high doses of caffeine ingested during pregnancy both for the mother and the developing foetus [2,3,7,15,16,18,22,25,27,30,31].…”

Section: Introductionmentioning

confidence: 99%

The temperature of caffeine administered during pregnancy and foetal morphometric parameters

et al. 2014

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Background: Caffeine is one of the most frequently ingested (at various tempe- Materials and methods: The research was conducted on rats. The fertilised females were randomly divided into two main groups: an experimental (E) and a control group (C). The experimental groups received caffeine (30 mg/day) in 10 (E1), 25 (E2) and 45°C (E3). The females in the control group were given water at the same temperature (C 1 , C 2 and C 3 ). On the 21 st day of pregnancy, the pregnant females were killed by decapitation using a specially prepared laboratory guillotine and were assessed morphometric parameters of foetuses.Results and Conclusions: Based on this work showed that: the embryotoxic effect of caffeine was only confined to a reduction in the number of offspring; the greatest changes in the morphometric parameters occurred in foetuses whose mothers received caffeine at 10°C; in the control groups, the greatest changes were observed in foetuses whose mothers were given water at 10°C during pregnancy. (Folia Morphol 2014; 72, 3: 347-352)

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“…Caffeine consumption has been associated with coronary heart disease, hypertension and adverse reproductive or developmental effects [7]. Olchowik et al [8] showed that caffeine intake during pregnancy (30 mg/day) had a negative influence on the bone tissue of female rats.…”

Section: Introductionmentioning

confidence: 99%

Use of X-ray microprobe to diagnose bone tissue demineralization after caffeine administration

Tomaszewski¹,

Olchowik²,

Tomaszewska³

et al. 2012

Folia Histochem Cytobiol.

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Abstract:Caffeine is a methylxanthine which permeates the placenta. In studies on animals, it has been shown to produce teratogenic and embryotoxic effects in large doses. The objective of this study was to assess the influence of caffeine on the development of bone tissue, with particular reference to elemental bone composition using an X-ray microprobe. The research was conducted on rats. The fertilized females were randomly divided into an experimental and a control group. The experimental group was given caffeine orally in 30 mg/day doses from the 8 th to the 21 st day of pregnancy, while the control group was given water. The fetuses were used to assess the growth and mineralization of the skeleton. On the basis of double dyeing, a qualitative analysis of the bone morphology and mineralization was conducted. For calcium and potassium analysis, an X-ray microprobe was used. In 67 fetuses from the experimental group, changes in skeleton staining with the alcian-alizarin method were noticed. The frequency of the development of variants in the experimental group was statistically higher. In the experimental group, a significant decrease in the calcium level, as well as an increase in the potassium level, was observed. The X-ray microprobe's undoubted advantage is that is offers a quick qualitative and quantitative analysis of the elemental composition of the examined samples. Employing this new technique may furnish us with new capabilities when investigating the essence of the pathology process.

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The influence of caffeine on the biomechanical properties of bone tissue during pregnancy in a population of rats

Cited by 22 publications

References 26 publications

Caffeine Intake during Pregnancy: What Are the Real Evidences?

Caffeine Intake during Pregnancy: What Are the Real Evidences?

The temperature of caffeine administered during pregnancy and foetal morphometric parameters

Use of X-ray microprobe to diagnose bone tissue demineralization after caffeine administration

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