The Influence of Body Mass Index and Weight Loss on Outcome of Elderly Patients Undergoing Lung Cancer Resection

Fiorelli, Alfonso; Vicidomini, Giovanni; Mazzella, Antonio; Messina, Gaetana; Milione, Roberta; Crescenzo, Vincenzo Giuseppe Di; Santini, Mario

doi:10.1055/s-0034-1373733

Cited by 51 publications

(70 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These AVM expand during pregnancy because of increases in blood volume, cardiac output, and venous distensibility [3]. In this occasion, the combined treatment of embolization with Onyx LES, a non-adhesive liquid embolic agent device utilized for the pre-surgical embolization of arteriovenous malformations (AVM’s), and subsequent lung wedge resection [10] involving AVM and decortication for lung re-expansion were performed. Women with known pulmonary AVM should be maximally treated prior to becoming pregnant, and the physician should be alert to complications of pulmonary AVM during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary arterovenous malformation causing hemothorax in a pregnant woman without Osler- Weber-Rendu syndrome

et al. 2015

Self Cite

View full text Add to dashboard Cite

Pulmonary arteriovenous malformations (PAVMs), although most commonly congenital, are usually detected later in life. Case report: We present a case of a 19-year-old woman with no previous history of AVM or telangiectasia, who presented dyspnea and hypoxia by massive left hemothorax in the 34th week of gestation. After emergent cesarean delivery, a chest computed tomography (CT) with i.v. contrast showed a likely 3 cm area of active contrast in left lower lung. Chest tube placement revealed about 2 liters of blood. The patient was subsequently found to have pulmonary AVM. A successful embolisation of AVM followed by lung atipic resection involving AVM and decortication for lung re-expansion were the treatments provided. Conclusions: Women with known pulmonary AVM should be maximally treated prior to becoming pregnant, and the physician should be alert to complications of pulmonary AVM during pregnancy.

show abstract

Section: Discussionmentioning

confidence: 99%

Pulmonary arterovenous malformation causing hemothorax in a pregnant woman without Osler- Weber-Rendu syndrome

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…Furthermore, proteomics can be used to monitor the patient status during all the treatment steps by means of a simple blood test. There is still the need for a comparison of the results produced by proteomic analyses against other diagnostic approaches based on blood test for assessing the risk of other diseases [Fiorelli et al, 2014].…”

Section: Plasma Proteomic In Lung Cancermentioning

confidence: 99%

Translational Research and Plasma Proteomic in Cancer

Santini

Giovane

Auletta

et al. 2015

J of Cellular Biochemistry

Self Cite

View full text Add to dashboard Cite

Proteomics is a recent field of research in molecular biology that can help in the fight against cancer through the search for biomarkers that can detect this disease in the early stages of its development. Proteomic is a speedily growing technology, also thanks to the development of even more sensitive and fast mass spectrometry analysis. Although this technique is the most widespread for the discovery of new cancer biomarkers, it still suffers of a poor sensitivity and insufficient reproducibility, essentially due to the tumor heterogeneity. Common technical shortcomings include limitations in the sensitivity of detecting low abundant biomarkers and possible systematic biases in the observed data. Current research attempts are trying to develop high-resolution proteomic instrumentation for high-throughput monitoring of protein changes that occur in cancer. In this review, we describe the basic features of the proteomic tools which have proven to be useful in cancer research, showing their advantages and disadvantages. The application of these proteomic tools could provide early biomarkers detection in various cancer types and could improve the understanding the mechanisms of tumor growth and dissemination.

show abstract

“…In the preoperative management of elderly patients, cardiovascular risk, respiratory function and the presence of comorbidities are thoroughly assessed. However, nutritional status assessment may be overlooked in routine preoperative evaluation, despite the fact that undernutrition is associated with an increased risk of poor tissue healing and impaired immune function (4), and previous studies reporting that poor nutritional status was associated with worse survival of elderly patients who underwent surgery for lung, ovarian and primary peritoneal cancer (4,5).…”

Section: Introductionmentioning

confidence: 99%

Underweight status predicts a poor prognosis in elderly patients with colorectal cancer

Kaneko¹,

Sasaki²,

Ozaki³

et al. 2016

Molecular and Clinical Oncology

View full text Add to dashboard Cite

Abstract. The aim of the present study was to evaluate the effect of underweight status on the survival of elderly patients undergoing surgery for colorectal cancer (CRC). A total of 113 patients aged ≥75 years who underwent curative surgery for CRC were included. In addition to standard perioperative variables, body mass index (BMI) was assessed. The patients were categorized as underweight (BMI<18.5 kg/m 2 ) or non-underweight (BMI≥18.5 kg/m 2 ). The 3-year overall survival (OS) and cancer-specific survival (CSS) were analyzed. Of the 113 patients, 24 (21%) were underweight. The two groups were well-balanced regarding all factors evaluated. In the multivariate analysis, underweight status was an independent indicator of lower 3-year OS [hazard ratio (HR)=2.65; 95% confidence interval (CI): 1.08-6.50; P= 0.033] and CSS (HR=3.51, 95% CI: 1.16-10.60; P=0.025) rates. Compared with the non-underweight group, the underweight group had significantly worse 3-year OS (66.7 vs. 86.5%, respectively; P= 0.017) and CSS (74.1 vs. 90.9%, respectively; P= 0.025) rates. Therefore, underweight status was a significant risk factor for poor survival in elderly CRC patients. The development of effective nutritional interventions may improve the prognosis of such patients.

show abstract

The Influence of Body Mass Index and Weight Loss on Outcome of Elderly Patients Undergoing Lung Cancer Resection

Cited by 51 publications

References 22 publications

Pulmonary arterovenous malformation causing hemothorax in a pregnant woman without Osler- Weber-Rendu syndrome

Pulmonary arterovenous malformation causing hemothorax in a pregnant woman without Osler- Weber-Rendu syndrome

Translational Research and Plasma Proteomic in Cancer

Underweight status predicts a poor prognosis in elderly patients with colorectal cancer

Contact Info

Product

Resources

About