The influence of ancillary ligands on the antitumoral activity of new cyclometallated Pt(II) complexes derived from an ferrocene-pyrazole hybrid

Catalyst‐Free Regioselective 1,2‐Diheterofunctionalization of Vinylferrocene

“…Subsequently, we examined the suitability of N-based nucleophiles as third components (Scheme 7). Given the pharmacological potential of certain ferrocene-containing pyrazole derivatives, [18] we conducted the reaction of vinylferrocene (1), NBS (2 a), and pyrazole (5, 1.5 equiv.) in dichloromethane at room temperature.…”

Novel multifunctional and multitarget homo- (Fe2) and heterobimetallic [(Fe,M) with M = Re or Mn] sulfonyl hydrazones

“…imines, hydrazones), b) their use as metalloligands in front of transition metals [26][27][28][29][30] and, c) the study of their properties, applications and catalytic and biological activities. [26][27][28][29][30][31][32][33][34] So far, we have achieved compounds with low toxicity in normal and non-tumoural cells, potent inhibitory growth effect in several cancer cell lines and an example 31,32 that shows synergic effect with cisplatin and induces the nuclear translocation of FOXO 3a tumour supresor 32b . More recently, we initiated a parallel study on cyrhetrene (M = Re) and cymantrene (M = Mn) derivatives as new anticancer or antiparasitic drug candidates.…”

Coordination complexes constructed from pyrazole–acetamide and pyrazole–quinoxaline: effect of hydrogen bonding on the self-assembly process and antibacterial activity

“…5 Pyrazole derivatives are biologically active heterocyclic compounds. [6][7][8] This substance class has been the topic of numerous pharmaceutical studies being used for their medicinal properties such as anti-inammatory, 9 antidiabetic, 10,11 antiviral, 12 analgesic, 13 antitumor, 14 catecholase, 15 and antimicrobial properties. 16 On other hand, nitrogen systems have attracted more attention in recent years because of their interesting properties in coordination chemistry.…”