The inductive effect of ginsenoside F2 on hair growth by altering the WNT signal pathway in telogen mouse skin

Shin, Heon-Sub; Park, Sang‐Yong; Hwang, Eunson; Lee, Don-Gil; Song, Hyun-Geun; Mavlonov, Gafurjon T.; Yi, Tae–Hoo

doi:10.1016/j.ejphar.2014.02.024

Cited by 46 publications

(43 citation statements)

References 31 publications

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“…The interactions between follicular keratinocytes and dermal papilla cells (specialized fibroblasts of the hair follicle) govern the formation of hair and hair cycling [5]. Several plant-derived compounds have been reported to induce hair growth, a promising therapeutic treatment for diseases such as alopecia [29,30]. In contrast, the effects of animal-derived dietary compounds such as collagen on hair biology have not been explored.…”

Section: Discussionmentioning

confidence: 99%

Effects of Food-Derived Collagen Peptides on the Expression of Keratin and Keratin-Associated Protein Genes in the Mouse Skin

Takatori

Iwamoto

et al. 2015

Skin Pharmacol Physiol

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Oral ingestion of collagen peptides (CP) has long been suggested to exert beneficial effects on the skin, but the molecular events induced by CP on the skin remain unclear. Here, we investigated the effects of oral CP administration on gene expression in hairless mouse skin and of prolyl-hydroxyproline (Pro-Hyp), a collagen-derived dipeptide, on gene expression in a coculture of mouse skin keratinocytes and fibroblasts. Using microarray analysis, we found that oral administration of CP to hairless mice for 6 weeks induced increased expression of Krtap and Krt genes in the skin. Annotation analysis using DAVID revealed that a group of the up-regulated genes, Gprc5d, Sprr2a1, Krt27 and Krtap16-7, is associated with the development of the epidermis and the hair cycle. In addition, the presence of Pro-Hyp (200 μM) induced an increase in the expression of Krtap16-7, Krtap15, Krtap14 and Krtap8-2 in keratinocytes in coculture, partially resembling the in vivo result. The Pro-Hyp-induced up-regulation of these genes was not observed when keratinocytes were cultured without fibroblasts, suggesting that the presence of fibroblasts is essential for the effects of Pro-Hyp. Our study presents new insights into the effects of CP on the skin, which might link to the hair cycle.

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Section: Discussionmentioning

confidence: 99%

Effects of Food-Derived Collagen Peptides on the Expression of Keratin and Keratin-Associated Protein Genes in the Mouse Skin

Takatori

Iwamoto

et al. 2015

Skin Pharmacol Physiol

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“…24 Even though our clinical trial was conducted in 18 drier weather conditions (i.e., from August 23 to November 17), we still noticed significant 19 improvements in skin moisture by EG treatment. This finding was corroborated by the 20 questionnaires, in which volunteers in the EG group noted more potent moisturizing effects 21 of treatment compared to the placebo group. In a previous study, we demonstrated that 22 increased epidermal hydration caused by EG treatment protected against UVB-induced 23 dryness in mouse dorsal skin.…”

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confidence: 67%

“…All 16 photographs were taken with subjects looking straight ahead under constant lighting 17 conditions with the same camera, camera settings, and camera placement. Thus, a Nikon 18 D200 camera was positioned on an SVK 35D tripod to the right of the subject's face and 19 perpendicular to the area to be photographed, while an Olympus twin T28 Macroflash unit 20 was positioned with one flash head directly above the lens pointed at the subject and the other 21 directed away. Exposure was controlled by adjusting the lens aperture with the flash set on 22 manual at full output.…”

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confidence: 99%

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Efficacy and Safety of Enzyme-Modified Panax ginseng for Anti-Wrinkle Therapy in Healthy Skin: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Study

Hwang

Park

et al. 2015

Rejuvenation Research

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Human skin undergoes changes during aging that result from the synergistic effects of intrinsic and extrinsic factors that may culminate in wrinkle formation, a characteristic of aged skin. Panax ginseng and ginsenosides have promising properties in preventing skin aging. Our previous study demonstrated that enzyme-modified ginseng extract (EG) has inhibitory effects against ultraviolet B (UVB) radiation-induced skin aging. The purpose of the current study was to evaluate the preventive effects of EG on eye-wrinkle formation by applying EG cream in 23 randomized human subjects. Compared to the placebo, EG significantly reduced the global photo-damage score. In addition, total roughness (R1), smoothness depth (R4), and arithmetic roughness average (R5) were significantly decreased with use of EG. In a post-study questionnaire, subjects responded that EG was absorbed efficiently into the skin and was more potent in moisturizing and softening skin than the placebo. No participants reported adverse reactions to treatment. In conclusion, EG sufficiently suppressed eye wrinkle formation by decreasing various roughness measures on the basis of assessment with non-invasive devices. Therefore, our results indicate that EG is a promising anti-aging candidate that could be used as an ingredient in natural functional food and cosmetic products.

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“…12) Ginsenoside F2 induces hair growth by modulating the WNT signaling pathway. 13) Ginsenoside Rg3 also promotes hair growth. 14) Ginsenoside Ro has anti-androgen effects 15) and 5α-reductase has an inhibitory effect on hair growth.…”

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confidence: 99%

Inhibitory Effects of Polyacetylene Compounds from <i>Panax ginseng</i> on Neurotrophin Receptor-Mediated Hair Growth

Suzuki

Matsuura²,

Kanatani³

et al. 2017

Biological & Pharmaceutical Bulletin

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Neurotrophins play an important role in the control of the hair growth cycle. Therefore, neurotrophin receptor antagonists have therapeutic potential for the treatment of hair growth disorders. In this study, we investigated the inhibitory effect of Panax ginseng, a medicinal plant commonly used to treat alopecia, on the binding of neurotrophins to their receptors. In addition, we isolated and characterized the bioactive compounds of P. ginseng extracts. P. ginseng hexane extracts strongly inhibited brain-derived neurotrophic factor (BDNF)-TrkB and β-nerve growth factor (β-NGF)-p75 neurotrophin receptor (p75NTR) binding. Furthermore, we identified the following 6 polyacetylene compounds as the bioactive components in P. ginseng hexane extract: panaxynol (1), panaxydol (2), panaxydol chlorohydrin (3), 1,8-heptadecadiene-4,6-diyne-3,10-diol (4), panaxytriol (5), and dihydropanaxacol (6). In particular, compounds 4, 5, and 6 significantly inhibited BDNF-TrkB binding in a dose-dependent manner. To identify the structural component mediating the inhibitory effect, we investigated the effects of the hydroxyl moiety in these compounds. We found that the inhibitory effect of panaxytriol (5) was strong, whereas the inhibitory effect of Ac-panaxytriol (7) was relatively weak. Our findings suggest that P. ginseng-derived polyacetylenes with a hydroxyl moiety might provide therapeutic benefits to patients with hair growth disorders such as alopecia by inhibiting the binding of neurotrophins to their receptors. Although saponins have been proposed to be the primary mediators of the effects of P. ginseng on hair growth, this study revealed that polyacetylene compounds exert similar effects.

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The inductive effect of ginsenoside F2 on hair growth by altering the WNT signal pathway in telogen mouse skin

Cited by 46 publications

References 31 publications

Effects of Food-Derived Collagen Peptides on the Expression of Keratin and Keratin-Associated Protein Genes in the Mouse Skin

Effects of Food-Derived Collagen Peptides on the Expression of Keratin and Keratin-Associated Protein Genes in the Mouse Skin

Efficacy and Safety of Enzyme-Modified Panax ginseng for Anti-Wrinkle Therapy in Healthy Skin: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Study

Inhibitory Effects of Polyacetylene Compounds from <i>Panax ginseng</i> on Neurotrophin Receptor-Mediated Hair Growth

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