The incidence of erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis. A population-based study with particular reference to reactions caused by drugs among outpatients

Associations of HLA genetic variants with carbamazepine‐induced cutaneous adverse drug reactions: An updated meta‐analysis

“…Besides, the impact of gender on the risk of severe cutaneous adverse drug reactions (SCARs) was also reported by other authors 25–27 and is consistent with the findings of the present analysis. Hsu et al 28 found a statistically significant sensitivity to SCARs in females compared to males in the American population.…”

Nationwide Survey of Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis in Children in the United States

“…The risk of death with SJS/TEN is different for adults and children. In previous studies, the risk in adults was 1% to 5% with SJS and 25% to 35% with TEN . Mortality in children was remarkably lower than in adults.…”

Epidemiology of Ophthalmologic Disease Associated with Erythema Multiforme, Stevens‐Johnson Syndrome, and Toxic Epidermal Necrolysis in Hospitalized Children in the United States

“…Our research confirms that EM/SJS/TEN is rare in children, but it is more common in hospitalized children than adults, who have an estimated incidence of 0.5 to 7.4 cases per million per year (4)(5)(6). The incidence rate is consistent with the only other reported pediatric incidence rate of 35.5 cases per million per year (5). Also consistent with past reports (3,7), children with EM/SJS/TEN had low mortality.…”

“…This is the first population-based study of the epidemiology, ophthalmologic diseases, and resource use of U.S. children hospitalized with EM/SJS/TEN. Our research confirms that EM/SJS/TEN is rare in children, but it is more common in hospitalized children than adults, who have an estimated incidence of 0.5 to 7.4 cases per million per year (4)(5)(6). The incidence rate is consistent with the only other reported pediatric incidence rate of 35.5 cases per million per year (5).…”