2014
DOI: 10.1371/journal.pone.0105804
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The Incidence of Coronary Heart Disease and the Population Attributable Fraction of Its Risk Factors in Tehran: A 10-Year Population-Based Cohort Study

Abstract: BackgroundData on incidence of coronary heart disease (CHD) is scarce in the Middle East and little is known about the contribution of known risk factors in this area.MethodsThe incidence of CHD and the effect of modifiable risk factors were explored in 2889 men and 3803 women aged 30–74 years in the population based cohort of the Tehran Lipid and Glucose Study, during 1999–2010. Average population attributable fraction (aPAF) was calculated for any risk factor using direct method based on regression model.Res… Show more

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Cited by 68 publications
(66 citation statements)
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References 30 publications
(37 reference statements)
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“…In the present study, high-risk age in men (15.0%), in comparison with women (6.3%) had a higher PAF, which was consistent with the results of two population based cohort studies conducted in Iran (36.1% in men vs. 16.6% in women and 42% in men vs. 22% in women) [26,27] and a study from…”
Section: Discussionsupporting
confidence: 92%
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“…In the present study, high-risk age in men (15.0%), in comparison with women (6.3%) had a higher PAF, which was consistent with the results of two population based cohort studies conducted in Iran (36.1% in men vs. 16.6% in women and 42% in men vs. 22% in women) [26,27] and a study from…”
Section: Discussionsupporting
confidence: 92%
“…The association between classic risk factors and CVD has been proven, but even for those risk factors with the same effect size, they can produce a completely different effect on the occurrence of disease due to the difference in the prevalence, so the calculation of PAF must be performed, using the population of the target community. In the present study, PAF of hypertension for CVDs has a higher value in women (42.8%) than in men (35.7%), and this difference has been reported from two population based cohort studies conducted in Iran (19.3% in women vs. 11.7% in men) and (17% in women vs. 9.4% in men) [26,27]. Also, it is consistent with the results of study in Sweden from "the Malmö preventive project" (23% in women vs. 12% in men) [28].…”
Section: Discussionsupporting
confidence: 63%
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“…The low performance of the ACC/AHA guideline for high dose statin therapy in women should not be translated to the low importance of hypercholesterolemia in them. Recently we revealed that hypercholesterolemia (total cholesterol ≥240 mg/dl) increases the risk of CVD up to 60% in both genders but with more population attributable risk in women than in men (12% vs. 7.3%) [25].…”
Section: Discussionmentioning
confidence: 99%
“…Considering the high prevalence and incidence of obesity and CVD among Middle Eastern populations,13, 14 this study was conducted to investigate the effect of different weight histories—including current and maximum BMI, current and maximum WC, duration of general and central adiposity, and cumulative excess BMI and WC, considering both duration and degree of overweight status or obesity—on CHD and stroke events among Iranian adults in the population‐based cohort of the TLGS (Tehran Lipid and Glucose Study).…”
Section: Introductionmentioning
confidence: 99%