The Incidence and Epidemiology of Hepatocellular Carcinoma: A Global and Regional Perspective

Venook, Alan P.; Papandreou, Christos N.; Furuse, Junji; Guevara, Laura Ladrón de

doi:10.1634/theoncologist.2010-s4-05

Cited by 861 publications

(692 citation statements)

References 55 publications

(74 reference statements)

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“…1 Chronic hepatitis B virus (HBV) infection is a major risk factor for HCC, especially in Asian countries. 2 Hepatitis B virus X protein (HBx) encoded by the X gene of HBV plays a pivotal role in the onset and progression of HBV-associated HCC.…”

Section: Introductionmentioning

confidence: 99%

Upregulation of PP2Ac predicts poor prognosis and contributes to aggressiveness in hepatocellular carcinoma

Gong

Feng

Song

et al. 2015

Cancer Biology & Therapy

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Protein phosphatase 2A (PP2A) is a heterotrimeric protein phosphatase consisting of a 36-k D catalytic C subunit (PP2Ac). This study aimed to explore the prognostic and biological significance of PP2Ac in human hepatocellular carcinoma (HCC). High PP2Ac expression was significantly (P < 0.01) associated with serum hepatitis B surface antigen positivity, serum hepatitis B e antigen positivity, liver cirrhosis, moderate to poor differentiation grade, advanced disease stage, intrahepatic metastasis, and early recurrence in HCC. Multivariate analysis revealed PP2Ac as an independent prognostic factor for overall survival. Enforced expression of hepatitis B virus X protein (HBx) and its carboxyl-terminal truncated isoform induced PP2Ac expression in HCC cells. Co-immunoprecipitation assay revealed a direct interaction between PP2Ac and HBx. Small interfering RNA-mediated knockdown of PP2Ac significantly inhibited in vitro cell proliferation, colony formation, migration, and invasion and reduced tumor growth in an xenograft mouse model. In contrast, overexpression of PP2Ac promoted HCC cell proliferation, colony formation, and tumorigenesis. Additionally, silencing of PP2Ac impaired the growth-promoting effects on HepG2 HCC cells elicited by overexpression of carboxyl-terminal truncated HBx. Gene expression profiling analysis showed that PP2Ac downregulation modulated the expression of numerous genes involved in cell cycle and apoptosis regulation. Collectively, PP2Ac upregulation has a poor prognostic impact on the overall survival of HCC patients and contributes to the aggressiveness of HCC. PP2Ac may represent a potential therapeutic target for HCC.

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Section: Introductionmentioning

confidence: 99%

Upregulation of PP2Ac predicts poor prognosis and contributes to aggressiveness in hepatocellular carcinoma

Gong

Feng

Song

et al. 2015

Cancer Biology & Therapy

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“…Globally, HCC took the third place in cancer related mortality and is also thought to be the first cause of death in cirrhotic patients (Parkin et al, 2001). The epidemiological distribution of HCC varies from one area to another area, the Southeast Asia and sub-Saharan Africa contributes mainly (Parikh and Hyman, 2007;Naqi et al, 2014) and lower, but on the increase, in North America and most of Europe (Venook et al, 2010). In Pakistan prevalence of HCC varies from 3.7% of all malignant tumors to 16% (Butt et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Viral Hepatitis-Associated Hepatocellular Carcinoma Due to HBV and HCV - Cohort from Liver Clinics in Pakistan

Munaf¹,

Memon²,

Kumar³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Therefore a wide range of patients are subjected to conventional chemotherapy and radiotherapy, in most cases without success. [1][2][3][4] This happens because there are differences in the response to these therapies due, at least in part, to the heterogeneity in expression of genes linked to chemoresistance and radioresistance, where the tumor suppressor gene p53 has a very important role. 5,6 Thus, it is important to find diagnostic tools to identify these genetic differences in order to develop more personalized therapies and increase the therapeutic success.…”

mentioning

confidence: 99%

Fluorine-18 Fluorodeoxyglucose Uptake in Hepatocellular Carcinoma: Correlation with Glucose Transporters and p53 Expression

Brito

Abrantes

Ribeiro

et al. 2015

Journal of Clinical and Experimental Hepatology

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Introduction: Hepatocellular Carcinoma (HCC) is one of most lethal cancers worldwide. The prognosis is very poor and therapeutic options are limited. The aim of this study was to determine the correlation of the [ 18 F]FDG uptake profile of three HCC cell lines with p53 and glucose transporters (GLUTs) 1, 2, 3, 5 and 12 expression and with the glucose level present in the cell culture medium. Methods: Cell lines used are HepG2 (wp53), HuH7 (overexpress p53) and Hep3B2.1-7 (p53null). An immunocytochemical analysis was performed to evaluate p53 expression. Through uptake studies were analyzed the

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The Incidence and Epidemiology of Hepatocellular Carcinoma: A Global and Regional Perspective

Abstract: ABSTRACT

Cited by 861 publications

References 55 publications

Upregulation of PP2Ac predicts poor prognosis and contributes to aggressiveness in hepatocellular carcinoma

Upregulation of PP2Ac predicts poor prognosis and contributes to aggressiveness in hepatocellular carcinoma

Comparison of Viral Hepatitis-Associated Hepatocellular Carcinoma Due to HBV and HCV - Cohort from Liver Clinics in Pakistan

Fluorine-18 Fluorodeoxyglucose Uptake in Hepatocellular Carcinoma: Correlation with Glucose Transporters and p53 Expression

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