The in vitro effects of chylomicron remnant and very low density lipoprotein remnant on platelet aggregation in blood obtained from healthy persons

Mochizuki, Masae; Takada, Yumiko; Urano, Tetsumei; Nagai, Nobuo; Nakano, Takamitsu; Nakajima, Katsuyuki; Takada, Akikazu

doi:10.1016/0049-3848(96)00033-3

Cited by 17 publications

(16 citation statements)

References 34 publications

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“…27 Increased lipid peroxidation may confer PE susceptibility by endothelial cell activation. 21 Similarly, triglyceride-rich lipoproteins have been suggested to trigger endothelial dysfunction 28 and artherothrombosis, 29 and they also play an important role in thrombin formation and may induce platelet aggregation, which can contribute to coagulopathy, another characteristic of PE. 30 An alternative explanation to downregulation of ACOX2 in PE might be through the bile acid intermediates.…”

Section: Discussionmentioning

confidence: 99%

Identification of ACOX2 as a shared genetic risk factor for preeclampsia and cardiovascular disease

et al. 2011

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Preeclampsia (PE) is a serious complication of pregnancy, which is highly correlated with later life cardiovascular disease (CVD). Many risk factors are common for both diseases, but the contribution of shared genes remains to be determined. In this study, we used an integrative strategy to assess lipid traits as risk factors for PE and CVD by whole genome transcriptional profiling performed on Norwegian decidua basalis tissues (N¼95) from preeclamptic and normal pregnancies and on blood lymphocytes (N¼1240) from the San Antonio Family Heart Study (SAFHS). Among 222 genes that were differentially expressed (false discovery rate (FDR) P-value o0.05) between the PE, cases and controls, we found one gene, ACOX2 (acyl-coenzyme A oxidase 2, branched chain), that was downregulated in PE whose transcription was also inversely correlated with triglyceride levels (P¼5.6Â10 À7 ; FDR P-value¼0.0002) in SAFHS. We further report associations between SNPs in the ACOX2 gene and the transcription level (P-value¼0.0045) of the gene, as well as with triglyceride levels (P-value¼0.0051). ACOX2 is involved in bile acid production, a process that has been associated with both oxidative stress and regulation of triglyceride levels. Oxidative stress and increased triglyceride levels are known risk factors for CVD and both have also been associated with PE. Our results suggest that downregulation of ACOX2 is a shared risk factor for PE and CVD.

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Section: Discussionmentioning

confidence: 99%

Identification of ACOX2 as a shared genetic risk factor for preeclampsia and cardiovascular disease

et al. 2011

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“…5 Triglyceride (TG) rich lipoproteins may also activate endothelial dysfunction 6 and atherothrombosis. 7 Malondialdehyde (MDA) is the end product of lipid peroxidation and reflects the oxidative status of the biological system 8 which causes damage to LDL molecules. The oxidized LDL is taken up by macrophages via scavenger receptors and form foam cells 9 resulting in atherogenesis.…”

Section: Introductionmentioning

confidence: 99%

Role of dyslipidaemia and lipid peroxidation in pregnancy induced hypertension

Saxena¹,

Thimmaraju²,

Srivastava³

et al. 2015

J Clin Sci Res

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Background: Pregnancy induced hypertension (PIH) contributes greatly to maternal morbidity and mortality. Altered lipid profile and increased lipid peroxidation activate endothelial dysfunction and atherothrombosis leading to PIH. Therefore, estimation of lipid profile with serum malondialdehyde (MDA) in pregnancy may be helpful in predicting the development of PIH and further progression. Material and methods:In this prospective case-control study, serum lipid profile and MDA were estimated in 70 PIH subjects with gestational hypertension, pre-eclampsia, eclampsia; and 70 normotensive pregnant women aged 18 -40 years, with gestational age of over 20 weeks.Results: A statistically significant higher serum total cholesterol, very low density lipoprotein cholesterol (VLDL-C), low density lipoprotein cholesterol (LDL-C), triglycerides (TG), TC/HDL-C, LDL-C/HDL-C and MDA, and a significantly lower HDL-C was noted in PIH subjects as compared to control subjects. When compared with the severity of PIH, all the lipoproteins (except HDL-C) along with MDA were found to be higher in women with eclampsia when compared with gestational hypertension, pre-eclampsia and normotensive pregnant women. Conclusions:An abnormal lipid metabolism along with oxidative stress may add to the promotion of vascular dysfunction leading to PIH. Lipoproteins and MDA alter significantly in eclampsia. Therefore, during pregnancy, early diagnosis and management of dyslipidaemia may prevent lipid peroxidation and progression of PIH thereby preventing obstetric complications.

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“…In PIH, the triglycerides are likely to be accumulated in vessels like uterine spiral arteries and contribute to endothelial damage by generating small, dense LDL particles. Women with PIH are more likely to develop overweight, dyslipidemia (16)(17)(18)(19)(20) , insulin resistance (21)(22) and endothelial dysfunction (23) , which are independent risk factors for cardiovascular disease (24)(25) .…”

mentioning

confidence: 99%

“…Abnormal lipid metabolism is responsible for the endothelial dysfunction (15) , and it was proposed that small, dense LDL may add to endothelial dysfunction in pre -eclampsia (16)(17) . Triglyceride rich lipoproteins may also activate endothelial dysfunction (18) and atherothrombosis (19) . In toxemia of pregnancy, serum triglyceride concentration increases much more notably.…”

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confidence: 99%

Study of Lipid Profile Trends in Women of Pregnancy Induced Hypertension Cases in a Rural Setup

Kaloti¹,

Kaur²,

K³

et al. 2013

jemds

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OBJECTIVE: Elevated plasma lipid levels are believed to be probable cause of endothelial cell dysfunction. We planned to measure the changes in the lipid levels in patients of PIH (pregnancy induced hypertension) and compare it with that of normotensive pregnant females. MATERIALS & METHODS:We studied 804 pregnant women. 624 patients studied were of PIH and 180 patients were healthy pregnant women. Lipid levels were estimated in these pregnant women. RESULTS: We found a significant rise in the serum lipid levels in the PIH patients group as compared to normotensive pregnant females, which were highly significant (P<0.001) except changes in LDL (P>0.05) and total cholesterol. Amongst the different lipoprotein ratios, TC: HDL, LDL: HDL, TG: HDL, and HDL: VLDL ratios were found highly significant (p<0.001) in PIH patients group. CONCLUSION: It is essential that blood lipid concentrations be estimated in pregnant women during antenatal care since it could be useful in early diagnosis and prevention of obstetric complications such as PIH. INTRODUCTION:Pregnancy induced hypertension is recognized since ancient times. It has been described in reviews of Thiagarajha and Chesley 1 .Hypertension after 20 weeks of pregnancy in a woman with edema and proteinuria without previous history of hypertension is called pregnancy induced hypertension (PIH). When associated with proteinuria, the disorder is termed pre -eclamptic eclampsia/ toxemia and when present without protein in the urine, it is called transient hypertension or gestational hypertension 2 . Raised blood pressure is present in 5% of entire pregnancies, in 10% of primiparous women and 20 -25% of women with pervious history of chronic hypertension. It is the major cause of fetomaternal morbidity and mortality 3 .When blood pressure rises in pregnancy with significant protein in the urine, it is called pre-eclampsia. It may occur from 20 weeks of pregnancy. It can also occur upto 6 weeks post partum. Delivery of the placenta is the ultimate treatment. It may affect both fetal and mother survival 4 .Eclampsia is a dangerous complication of pregnancy with a sudden onset and has the features of developing tonic -colonic seizures in a patient who has pre -eclampsia. With increasing age, the risk of developing PIH increases 5 .

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The in vitro effects of chylomicron remnant and very low density lipoprotein remnant on platelet aggregation in blood obtained from healthy persons

Cited by 17 publications

References 34 publications

Identification of ACOX2 as a shared genetic risk factor for preeclampsia and cardiovascular disease

Identification of ACOX2 as a shared genetic risk factor for preeclampsia and cardiovascular disease

Role of dyslipidaemia and lipid peroxidation in pregnancy induced hypertension

Study of Lipid Profile Trends in Women of Pregnancy Induced Hypertension Cases in a Rural Setup

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