The in vitro activities of pathogenic mineral dusts

In vitro genotoxic activities of fibrous erionite

“…Many inorganic dusts have been shown to be carcinogenic in experimental animals and it has been suggested that a correlation exists between the pathogenicity of a dust in vivo and its cytotoxicity in vitro (Brown et al, 1979;. Other in vitro tests especially designed to detect genotoxicity have, however, generally given more variable results.…”

“…In contrast, although in vitro studies had previously demonstrated a strong correlation between the in vitro cytotoxicity of fibrous dusts and their in vivo pathogenecity (Brown et al, 1978;, erionite was not more cytotoxic than other pathogenic dusts (Brown et al, 1980). While the detection of conventional genotoxicity with asbestos is problematic (Chamberlain, 1982), it was considered that the high in vivo pathogenicity of erionite should be reflected in any relevant in vitro activity.…”

In vitro genotoxic activities of fibrous erionite

“…Many inorganic dusts have been shown to be carcinogenic in experimental animals and it has been suggested that a correlation exists between the pathogenicity of a dust in vivo and its cytotoxicity in vitro (Brown et al, 1979;. Other in vitro tests especially designed to detect genotoxicity have, however, generally given more variable results.…”

“…In contrast, although in vitro studies had previously demonstrated a strong correlation between the in vitro cytotoxicity of fibrous dusts and their in vivo pathogenecity (Brown et al, 1978;, erionite was not more cytotoxic than other pathogenic dusts (Brown et al, 1980). While the detection of conventional genotoxicity with asbestos is problematic (Chamberlain, 1982), it was considered that the high in vivo pathogenicity of erionite should be reflected in any relevant in vitro activity.…”

Final Report on the Safety Assessment of Aluminum Silicate, Calcium Silicate, Magnesium Aluminum Silicate, Magnesium Silicate, Magnesium Trisilicate, Sodium Magnesium Silicate, Zirconium Silicate, Attapulgite, Bentonite, Fuller's Earth, Hectorite, Kaolin, Lithium Magnesium Silicate, Lithium Magnesium Sodium Silicate, Montmorillonite, Pyrophyllite, and Zeolite

“…Concentrations that inhibited plating were estimated using the LD 50 . Compared to the positive control and the erionite samples, the Zeolite had a much greater LD 50 value and was nontoxic in the A549 assay (Brown et al 1980).…”

In Vivo Fate of Diatom-Based Nanocarriers: Advances, Challenges, and Future Perspectives

“…Thus, in this study, the major mechanism of toxicity was cytostasis and cytokinesis which was dependent on particle number and particle size [ 90 ]. Another in vitro study also reported that natural diatomaceous earth was more potent than calcined form in inducting both hemolysis and the release of intracellular and lysosomal enzymes from macrophages [ 94 ]. Likewise, whether crystalline silica is carcinogenic to humans is still a debated issue in scientific literature.…”

In vitro genotoxic activities of fibrous erionite

“…Many inorganic dusts have been shown to be carcinogenic in experimental animals and it has been suggested that a correlation exists between the pathogenicity of a dust in vivo and its cytotoxicity in vitro (Brown et al, 1979;. Other in vitro tests especially designed to detect genotoxicity have, however, generally given more variable results.…”

“…In contrast, although in vitro studies had previously demonstrated a strong correlation between the in vitro cytotoxicity of fibrous dusts and their in vivo pathogenecity (Brown et al, 1978;, erionite was not more cytotoxic than other pathogenic dusts (Brown et al, 1980). While the detection of conventional genotoxicity with asbestos is problematic (Chamberlain, 1982), it was considered that the high in vivo pathogenicity of erionite should be reflected in any relevant in vitro activity.…”

Final Report on the Safety Assessment of Aluminum Silicate, Calcium Silicate, Magnesium Aluminum Silicate, Magnesium Silicate, Magnesium Trisilicate, Sodium Magnesium Silicate, Zirconium Silicate, Attapulgite, Bentonite, Fuller's Earth, Hectorite, Kaolin, Lithium Magnesium Silicate, Lithium Magnesium Sodium Silicate, Montmorillonite, Pyrophyllite, and Zeolite

“…Concentrations that inhibited plating were estimated using the LD 50 . Compared to the positive control and the erionite samples, the Zeolite had a much greater LD 50 value and was nontoxic in the A549 assay (Brown et al 1980).…”

In Vivo Fate of Diatom-Based Nanocarriers: Advances, Challenges, and Future Perspectives

“…Thus, in this study, the major mechanism of toxicity was cytostasis and cytokinesis which was dependent on particle number and particle size [ 90 ]. Another in vitro study also reported that natural diatomaceous earth was more potent than calcined form in inducting both hemolysis and the release of intracellular and lysosomal enzymes from macrophages [ 94 ]. Likewise, whether crystalline silica is carcinogenic to humans is still a debated issue in scientific literature.…”

In vitro genotoxic activities of fibrous erionite

“…Many inorganic dusts have been shown to be carcinogenic in experimental animals and it has been suggested that a correlation exists between the pathogenicity of a dust in vivo and its cytotoxicity in vitro (Brown et al, 1979;. Other in vitro tests especially designed to detect genotoxicity have, however, generally given more variable results.…”

“…In contrast, although in vitro studies had previously demonstrated a strong correlation between the in vitro cytotoxicity of fibrous dusts and their in vivo pathogenecity (Brown et al, 1978;, erionite was not more cytotoxic than other pathogenic dusts (Brown et al, 1980). While the detection of conventional genotoxicity with asbestos is problematic (Chamberlain, 1982), it was considered that the high in vivo pathogenicity of erionite should be reflected in any relevant in vitro activity.…”

Final Report on the Safety Assessment of Aluminum Silicate, Calcium Silicate, Magnesium Aluminum Silicate, Magnesium Silicate, Magnesium Trisilicate, Sodium Magnesium Silicate, Zirconium Silicate, Attapulgite, Bentonite, Fuller's Earth, Hectorite, Kaolin, Lithium Magnesium Silicate, Lithium Magnesium Sodium Silicate, Montmorillonite, Pyrophyllite, and Zeolite

“…Concentrations that inhibited plating were estimated using the LD 50 . Compared to the positive control and the erionite samples, the Zeolite had a much greater LD 50 value and was nontoxic in the A549 assay (Brown et al 1980).…”

In Vivo Fate of Diatom-Based Nanocarriers: Advances, Challenges, and Future Perspectives

“…Thus, in this study, the major mechanism of toxicity was cytostasis and cytokinesis which was dependent on particle number and particle size [ 90 ]. Another in vitro study also reported that natural diatomaceous earth was more potent than calcined form in inducting both hemolysis and the release of intracellular and lysosomal enzymes from macrophages [ 94 ]. Likewise, whether crystalline silica is carcinogenic to humans is still a debated issue in scientific literature.…”