ABSTRACTPurpose: Quantify the levels of oxidative DNA damage of epithelial colon cells comparing segments with and without fecal stream. Methods: Sixty Wistar rats were subjected to deviation of fecal stream by proximal colostomy and a distal mucosal fistula. Animals were divided into three experimental groups that were sacrificed 6, 12 and 24 weeks after surgery. In each experimental group, five animals underwent laparotomy without intestinal deviation (sham subgroup). The diagnosis of colitis was made by hi…
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