The implication of protein malnutrition on cardiovascular control systems in rats

Silva, Fernanda C.; Menezes, Rodrigo Cunha Alvim de; Chianca, Deoclécio A.

doi:10.3389/fphys.2015.00246

Cited by 11 publications

(31 citation statements)

References 100 publications

(207 reference statements)

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“…Other experimental models of protein malnutrition, where offspring were subjected to protein deprivation following weaning, showed an evident BR dysfunction and establishment of hypertension. 31,32,41,42 This evidence supports the hypothesis that timing exposure is important to determine cardiovascular outcomes and suggests that a maternal diet poor in protein may induce adaptive mechanisms to protect the body from further damage, without affecting the development of the baroreceptors.…”

Section: Discussionsupporting

confidence: 71%

Hypertension in rat offspring subjected to perinatal protein malnutrition is not related to the baroreflex dysfunction

Paulino-Silva

Costa‐Silva

2016

Clin Exp Pharma Physio

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This study reports on the effects of maternal protein malnutrition on baroreflex (BR) control of the heart rate and sympathetic nerve activity in the hypertensive male offspring of Wistar rat dams. Wistar rat dams were fed a normal protein (NP) control (17% protein) or a low protein (LP; 8% protein) diet during pregnancy and lactation, and their male offspring were studied when 90 days old. In these animals we evaluated spontaneous and induced BR control, the variability of the cardiovascular system and analyzed a direct recording of lumbar sympathetic nervous activity. The 90 day-old LP conscious rats had increased arterial pressure compared to NP, with enhanced low frequency oscillations of the systolic pressure, but no changes in the spontaneous and induced BR control of heart rate. In relation to nerve recordings, we observed similar values in terms of mean, frequency and amplitude between the groups. In addition, we noted that spontaneous and induced BR control of lumbar sympathetic activity in the LP group was similar to the control group. The data indicate that hypertension in the adult rat offspring subjected to perinatal protein malnutrition is not related to baroreflex dysfunction.

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Section: Discussionsupporting

confidence: 71%

Hypertension in rat offspring subjected to perinatal protein malnutrition is not related to the baroreflex dysfunction

Paulino-Silva

Costa‐Silva

2016

Clin Exp Pharma Physio

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“…First, animal experiments reveal that malnutrition in early life was associated with reconstruction of arterial wall and higher arterial stiffness and blood pressure in later life. 26,27 Similarly, people with in utero Abbreviations: CI = confidence interval; HR = hazard ratio; ICH = intracerebral hemorrhage. a Deep hematoma: basal, ganglia, thalami hematoma, cerebellar, and brainstem.…”

Section: Discussionmentioning

confidence: 99%

In utero exposure to the Great Chinese Famine and risk of intracerebral hemorrhage in midlife

Gurol

et al. 2020

Neurology

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ObjectiveTo investigate whether in utero exposure to the Great Chinese Famine in 1959 to 1961 was associated with risk of intracerebral hemorrhage (ICH) in adulthood.MethodsIn this cohort analysis, we included 97,399 participants of the Kailuan Study who were free of cardiovascular disease and cancer at baseline (2006). Cases of incident ICH were confirmed by medical record review. We used the Cox proportional hazards model to calculate the hazard ratio (HR) and 95% confidence interval (CI) for ICH according to in utero famine exposure status.ResultsAmong 97,399 participants in the current analyses, 6.3% (n = 6,160) had been prenatally exposed to the Great Chinese Famine. During a median 9.0 years of follow-up (2006–2015), we identified 724 cases of incident ICH. After adjustment for potential confounders, the HR of ICH was 1.99 (95% CI 1.39–2.85) for in utero famine-exposed individuals vs individuals who were not exposed to the famine. When exposure to famine and severity of famine were examined jointly, the adjusted HR was 2.99 (95% CI 1.21–7.39) for in utero exposure to severe famine and 1.94 (95% CI 1.32–2.84) for in utero exposure to less severe famine relative to those without exposure to famine.ConclusionsIndividuals with in utero exposure to famine, especially those exposed to severe famine, were more likely to have ICH in midlife, highlighting the role of nutritional factors in susceptibility to this severe cerebral condition.

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“…Offspring of rats that were undernourished during the entire period of gestation and lactation showed raised catecholamine levels, an increase in catecholamine receptors and diminished cardiac beta-adrenergic responsiveness (12, 13). A review of studies of rats that were exposed to protein malnutrition in early life showed several effects on cardiovascular control systems, including increased sympathetic and decreased parasympathetic nervous system activity (14). There is also some evidence in humans that poor maternal nutritional status may impact sympathetic nervous system activity in the offspring, although the direction of the association is opposite to that demonstrated in most animal work.…”

Section: Introductionmentioning

confidence: 99%

Prenatal Undernutrition and Autonomic Function in Adulthood

et al. 2016

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Objectives-Early life adversity has been shown to be associated with cardiovascular disease and mortality in later life, but little is known about the mechanisms that underlie this association. Prenatal undernutrition, a severe early life stressor, is associated with double the risk of coronary heart disease and increased blood pressure responses to psychological stress. In the present study, we tested the hypothesis that prenatal undernutrition induces alterations in the autonomic nervous system, which may increase the risk of developing heart disease.Methods-We studied autonomic function in 740 men and women (aged 58 years, SD 0.9 years) who were members of the Dutch famine birth cohort. We compared those exposed to famine during early (n=64), mid (n=107) or late gestation (n=127) to those unexposed to famine in utero (n=442). Participants underwent a series of three psychological stressors (Stroop, mirror-tracing and speech) whilst their blood pressure and heart rate were recorded continuously.Results-Data had sufficient quality in 602 participants for derivation of autonomic function indices by spectral analysis. The stress protocol led to significant sample-level changes in SBP, HR and all cardiovascular control measures (all p < .001). None of the autonomic function parameters, at rest or in response to stress, differed significantly (all p > 0.050) according to prenatal famine exposure.Conclusion-Prenatal undernutrition was not associated with autonomic function in late adulthood. We conclude that altered autonomic function does not seem to explain our previous findings of increased CHD risk among those exposed to famine prenatally.

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The implication of protein malnutrition on cardiovascular control systems in rats

Cited by 11 publications

References 100 publications

Hypertension in rat offspring subjected to perinatal protein malnutrition is not related to the baroreflex dysfunction

Hypertension in rat offspring subjected to perinatal protein malnutrition is not related to the baroreflex dysfunction

In utero exposure to the Great Chinese Famine and risk of intracerebral hemorrhage in midlife

Prenatal Undernutrition and Autonomic Function in Adulthood

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