The impact of the gut microbiota on the reproductive and metabolic endocrine system

Qi, Xinyu; Yun, Chuyu; Pang, Yanli; Qiao, Jie

doi:10.1080/19490976.2021.1894070

Cited by 177 publications

(82 citation statements)

References 172 publications

(205 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, ghrelin, obestatin, insulin, and other gut-derived hormones have direct or indirect effects on the reproductive axis and play roles in regulating energy balance and reproductive function [27]. Previous studies have shown that the gut microbiota plays an important role in regulating the reproduction of the host [28,29]. However, there are no related studies that reported the association between the gut microbiota and seasonal breeding.…”

Section: Introductionmentioning

confidence: 99%

Seasonal Changes in the Distinct Taxonomy and Function of the Gut Microbiota in the Wild Ground Squirrel (Spermophilus dauricus)

Yang

Yao

Zhang

et al. 2021

Animals

View full text Add to dashboard Cite

Seasonal breeding is a normal phenomenon in which animals adapt to natural selection and reproduce only in specific seasons. Large studies have reported that the gut microbiota is closely related to reproduction. The purpose of this study was to explore the distinct taxonomy and function of the gut microbiota in the breeding and non-breeding seasons of the wild ground squirrel (Spermophilus dauricus). The 16S rRNA gene sequencing technology was utilized to sequence the gut microbiota of the wild ground squirrel. PICRUSt analysis was also applied to predict the function of the gut microbiota. The results suggested that the main components of the gut microbiota in all samples were Firmicutes (61.8%), Bacteroidetes (32.4%), and Proteobacteria (3.7%). Microbial community composition analyses revealed significant differences between the breeding and non-breeding seasons. At the genus level, Alistipes, Mycoplasma, Anaerotruncus, and Odoribacter were more abundant in the non-breeding season, while Blautia and Streptococcus were more abundant in the breeding season. The results of a functional prediction suggested that the relative abundance of functional categories that were related to lipid metabolism, carbohydrate metabolism, and nucleotide metabolism increased in the breeding season. The relative abundance of energy metabolism, transcription, and signal transduction increased in the non-breeding season. Overall, this study found differences in the taxonomy and function of the gut microbiota of the wild ground squirrel between the breeding and non-breeding seasons, and laid the foundation for further studies on the relationship between the gut microbiota and seasonal breeding.

show abstract

Section: Introductionmentioning

confidence: 99%

Seasonal Changes in the Distinct Taxonomy and Function of the Gut Microbiota in the Wild Ground Squirrel (Spermophilus dauricus)

Yang

Yao

Zhang

et al. 2021

Animals

View full text Add to dashboard Cite

show abstract

“…In their study, Song et al demonstrated that patients with subclinical hypothyroidism present reduced serum levels of bile acids [93]. Qi et al reported that the most prominent secondary bile acid in hypothyroidism is DCA, while CDCA is the most prominent in hyperthyroid patients [29,96]. Liu et al documented a significant decline in chenodeoxycholic, glycodeoxycholic (GCDA), and deoxycholic acid in hyperthyroid patients, with elevated cholic acid and reduced GCDA in hypothyroid individuals [95].…”

Section: Secondary Bile Acidsmentioning

confidence: 99%

Microbiome Metabolites and Thyroid Dysfunction

Bargiel

Stachowska

Prowans

et al. 2021

JCM

View full text Add to dashboard Cite

Thyroid diseases are common conditions that have a negative impact on the health of all populations. The literature sheds light on the differences in the composition of the intestinal microbiota in patients suffering from thyroid diseases compared to healthy individuals. The microbiome affects the proper functioning of the thyroid gland, and the existence of the gut–thyroid axis is discussed in the context of both thyroid diseases and intestinal dysbiosis. The purpose of this review is to describe associations between the microbiome and its metabolites and thyroid dysfunction. We try to explain the role of the microbiome in the metabolism of thyroid hormones and the impact of thyroid autoimmune diseases. In addition, we raise issues related to the influence of bacterial metabolites, such as short-chain fatty acids or secondary bile acids, in the functioning of the thyroid gland. Last but not least, we explored the interactions between the gut microbiota and therapeutics and supplements typically administered to patients with thyroid diseases.

show abstract

“…Several pathways have been proposed in the regulation of lipid metabolism mediated by gut microbiota ( Figure 1 ). Gut microbiota and the related metabolites could protect or disrupt the integrity of the intestine, thereby affecting the function of peripheral tissues ( Qi et al., 2021 ). Gut microbiota can regulate the brain–gut axis through immune response and the vagus nerve.…”

Section: Relationship Between Gut Microbiota and Hyperlipidemiamentioning

confidence: 99%

Impact of Gut Microbiota and Microbiota-Related Metabolites on Hyperlipidemia

Jia

Zhang

et al. 2021

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Hyperlipidemia, defined as the presence of excess fat or lipids in the blood, has been considered as a high-risk factor and key indicator of many metabolic diseases. The gut microbiota has been reported playing a vital role in regulating host lipid metabolism. The pathogenic role of gut microbiota in the development of hyperlipidemia has been revealed through fecal microbiota transplantation experiment to germ-free mice. The effector mechanism of microbiota-related metabolites such as bile acids, lipopolysaccharide, and short-chain fatty acids in the regulation of hyperlipidemia has been partially unveiled. Moreover, studies on gut-microbiota-targeted hyperlipidemia interventions, including the use of prebiotics, probiotics, fecal microbiota transplantation, and natural herbal medicines, also have shown their efficacy in the treatment of hyperlipidemia. In this review, we summarize the relationship between gut microbiota and hyperlipidemia, the impact of gut microbiota and microbiota-related metabolites on the development and progression of hyperlipidemia, and the potential therapeutic management of hyperlipidemia targeted at gut microbiota.

show abstract

The impact of the gut microbiota on the reproductive and metabolic endocrine system

Cited by 177 publications

References 172 publications

Seasonal Changes in the Distinct Taxonomy and Function of the Gut Microbiota in the Wild Ground Squirrel (Spermophilus dauricus)

Seasonal Changes in the Distinct Taxonomy and Function of the Gut Microbiota in the Wild Ground Squirrel (Spermophilus dauricus)

Microbiome Metabolites and Thyroid Dysfunction

Impact of Gut Microbiota and Microbiota-Related Metabolites on Hyperlipidemia

Contact Info

Product

Resources

About