The Impact of T Cell Vaccination in Alleviating and Regulating Systemic Lupus Erythematosus Manifestation

Abstract

Objective. Systemic lupus erythematosus (SLE) is an autoimmune disease identified by a plethora of production of autoantibodies. Autoreactive T cells may play an important role in the process. Attenuated T cell vaccination (TCV) has proven to benefit some autoimmune diseases by deleting or suppressing pathogenic T cells. However, clinical evidence for TCV in SLE is still limited. Therefore, this self-controlled study concentrates on the clinical effects of TCV on SLE patients. Methods. 16 patients were enrolled in the study; they accepted TCV regularly. SLEDAI, clinical symptoms, blood parameters including complements 3 and 4 levels, ANA, and anti-ds-DNA antibodies were tested. In addition, the side effects and drug usage were observed during the patients' treatment and follow-up. Results. Remissions in clinical symptoms such as facial rash, vasculitis, and proteinuria were noted in most patients. There are also evident reductions in SLEDAI, anti-ds-DNA antibodies, and GC dose and increases in C3 and C4 levels, with no pathogenic side effects during treatment and follow-up. Conclusions. T cell vaccination is helpful in alleviating and regulating systemic lupus erythematosus manifestation.

Serum amyloid A‐to‐albumin ratio as a potential biomarker to predict the activity, severity, and poor prognosis of systemic lupus erythematosus

“…Disease recurrence is defined as the increase of SLEDAI ≥3 after stabilization, or patients develop new skin and oral ulcer, serositis, arthritis, fever, central nervous system changes, vasculitis, nephritis, myositis, platelet count ≤60 × 10 9 /L, hemolytic anemia (hemoglobin <70g/L), or patients need to strengthen immunosuppressive treatment and hospitalization. 19 …”

“…Disease recurrence is defined as the increase of SLEDAI ≥3 after stabilization, or patients develop new skin and oral ulcer, serositis, arthritis, fever, central nervous system changes, vasculitis, nephritis, myositis, platelet count ≤60 × 10 9 /L, hemolytic anemia (hemoglobin <70g/L), or patients need to strengthen immunosuppressive treatment and hospitalization. 19 Kaplan-Meier (K-M) analysis was used to estimate the survival curve of sustained remission between different groups, and logrank test was used to analyze the differences between two groups. p < 0.05 means the difference was statistically significant.…”

Systemic Lupus Erythematosus and DNA Degradation and Elimination Defects

“…Additionally, simultaneously high levels of anti-dsDNA, anti-nucleosome, and anti-histone antibodies in serum suggest that defective DNA degradation marks the genesis of SLE (19) and can indicate severe nephropathy in SLE. In summary, these findings improve our understanding of the role of T cells in SLE (20). During SLE pathogenesis, autoreactive T cells trigger the differentiation, proliferation, and maturation of B cells, thus supporting the formation of autoantibodies.…”