2020 DOI: 10.20944/preprints202009.0159.v1 View full text Preprint
Khoa Nguyen, Keiko Kanamori, Abdul Hamid, Kabirullah Lutfy

Abstract: We assessed if there were any sex-related differences in the ability of nicotine to increase plasma corticosterone secretion after single or repeated nicotine administration. For single-dose studies, male and female mice were habituated to the test room for 1 h and injected with saline or nicotine (0.25 or 1 mg/kg, s.c.). In repeated-dosing studies, mice were injected with saline or nicotine (1 mg/kg, s.c.) once daily for six days, and, on day 7, received nicotine (1 mg/kg, s.c.). The mice were euthanized 15 m…

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