2014
DOI: 10.1007/s00330-014-3467-4
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Objective To evaluate the impact of radiological expertise on screen result decisions in a CT lung cancer screening trial. Methods In the NELSON lung cancer screening trial, the baseline CT result was based on the largest lung nodule's volume. The protocol allowed radiologists to manually adjust screen results in cases of high suspicion of benign or malignant nodule nature. Participants whose baseline CT result was based on a solid or part-solid nodule were included in this study. Adjustments by radiologists a… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
8
0

Year Published

2015
2015
2019
2019

Publication Types

Select...
8
1

Relationship

2
7

Authors

Journals

citations
Cited by 13 publications
(8 citation statements)
references
References 28 publications
0
8
0
Order By: Relevance
“…19 The NELSON trial also showed that radiologist expertise can reduce the number of false-positive results. 25 Strict adherence to a diagnostic protocol such as I-ELCAP 26 as well as increasing the rate of preoperative nodule biopsy in highly suspicious lesions should reduce these numbers so that fewer patients are subject to surgery which may not benefit them, with the associated risks and costs.…”
Section: Discussionmentioning
confidence: 99%
“…19 The NELSON trial also showed that radiologist expertise can reduce the number of false-positive results. 25 Strict adherence to a diagnostic protocol such as I-ELCAP 26 as well as increasing the rate of preoperative nodule biopsy in highly suspicious lesions should reduce these numbers so that fewer patients are subject to surgery which may not benefit them, with the associated risks and costs.…”
Section: Discussionmentioning
confidence: 99%
“…In this analysis, a nodule was considered new if it was registered by the radiologist as new or below the study detection limit of 15 mm 3 on the previous scan. Radiologists could overrule protocol-based screening result (done for 195 (6%) of 3318 participants at the baseline screening round) in case of high suspicion of malignancy (eg, enlarged mediastinal lymph nodes) or benignity (eg, benign calcification patterns) and to adjust the volume measurement in case of inappropriate segmentation 18. Data obtained during CT evaluation were directly uploaded to the NELSON management system 7.…”
Section: Methodsmentioning
confidence: 99%
“…These advances in radiological techniques allow the detection of small indeterminate nodules that would otherwise have not been possible with the use of plain X-ray technique, thus increasing the likelihood of a CT detected nodule to be malignant. [7][8][9] To address the challenging question that CT detected lung nodule is more likely to be malignant, the medical records and relevant CT scans of children and adults who had been referred to our institution for the evaluation of indeterminate lung nodules and lung metastasis were reviewed. The patients' clinical or radiographic characteristics were correlated with histologic features of nodules and disease stage.…”
Section: Introductionmentioning
confidence: 99%