The Impact of Proteomic Investigations on the Development and Improvement of Skin Laser Therapy: A Review Article

Shahrokh, Shabnam; Razzaghi, Zahra; Mansouri, Vahid; Ahmadi, Nayeb Ali

doi:10.15171/jlms.2019.s16

Cited by 6 publications

(6 citation statements)

References 54 publications

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“…Proteomics has less technical limitations on protein identification and a large number of proteins could be identified by this technique. 71 Proteomic analysis of foot skin compared to breast skin demonstrated the presence of 50 ECM common proteins in both skins, but there was a difference between the expressions of tenascin-x in breast skin and serum amyloid p component in foot skin. 72 By examining the proteomic profile of elderly epidermis, it was found that interferonstimulating polypeptides expression increased, causing the stimulation of phosphatidylinositol 3-kinase and manganese superoxide dismutase.…”

Section: Molecular Aspects Of Laser Effects In Cell Biologymentioning

confidence: 96%

Assessment of Laser Effects on Skin Rejuvenation

et al. 2020

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Laser skin resurfacing has changed the approach of facial skin rejuvenation over the past decade. This article evaluates the laser effects on skin rejuvenation by the assessment of laser characteristics and histological and molecular changes, accompanied by the expression of proteins during and after laser-assisted rejuvenation of skin. It is important to note that different layers of skin with different cells are normally exposed to the sun’s UV radiation which is the most likely factor in aging and damaging healthy skin. To identify the expression of proteins, using validated databases and reviewing existing data could reveal altered proteins which could be analyzed and mapped to investigate their expression and their different effects on cell biological responses. In this regard, proteomics data can be used for better investigation of the changes in the proteomic profile of the treated skin. Different assessments have revealed the survival and activation of fibroblasts and new keratinocytes with an increase of collagen and elastin fibers in the dermis and the reduction of matrix metalloproteinases (MMPs) and heat shock proteins (HSPs) as a result of different lowpower laser therapies of skin. There are a wide range of biological effects associated with laser application in skin rejuvenation; therefore, more safety considerations should be regarded in the application of lasers in skin rejuvenation.

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Section: Molecular Aspects Of Laser Effects In Cell Biologymentioning

confidence: 96%

Assessment of Laser Effects on Skin Rejuvenation

et al. 2020

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“…In these fields, the laser stimulates or inhibits cell and tissue function which leads to clinical effects finally. [17][18][19][20] Before laser therapy, patients' history including abnormal scarring, allergy, excessive sun exposure, herpes virus infection, any vascular and immunological disorders, tissue reinforced with silicone, smoking, and former cosmetic surgery must be considered. Because many drugs including amiodarone, minocycline, warfarin, isotretinoin, aspirin, niacin, vitamin E cause delayed healing, bleeding, scarring, increased bruising, hyperpigmentation, and localized chrysiasis after laser therapy, the medications that the patients have taken must be considered.…”

Section: Epidermal Side Effects Of Laser Therapymentioning

confidence: 99%

Evaluation of Laser Effects on the Human Body After Laser Therapy

et al. 2020

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Lasers have wide applications in the treatment and diagnosis of diseases and various medical fields. Laser therapy like the other methods has advantages and disadvantages. Some risks such as bleeding, pain, and infection are created after laser therapy. Explanation and evaluation of laser effects on cell function, tissue, and the body are the aims of this study. We reviewed papers available from 1986 to 2019 about the effects of lasers on cells and tissue. An online search of PubMed, Science Direct and Google scholar using such keywords as "laser", "cell", "tissue", "body" and "side effects" was performed. The laser photons are absorbed by chromophores, resulting in the target heating and localized damage. Laser irradiation alters cellular metabolism and cellular functions. These alterations may be accompanied by undesired side effects which can be monitored via metabolites level change in the body. Based on this finding, laser therapy may be associated with several side effects and complications; therefore, before treatment, the determination of laser types and their properties is necessary to avoid creating side effects. The advantages and disadvantages of the treatment type should be considered in order to choose the best treatment with the least side effects. The patients’ awareness of possible side effects before treatment and also an effective follow-up and management of patients after action are two important points in laser therapy. Training curriculum definition should be determined for laser applicant qualifications in different medical fields.

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“…The second group of genes (the DEGs that existed in the control and light-damage analysis but were absent in the PBM and PBM+light-damage analysis) was selected to screen via PPI network analysis by using Cytoscape software. 13 The genes were imported in Cytoscape and included in a network via the "protein query" of the STRING database. Due to poor interaction between the query genes, the 20 first neighbors of the nodes were added to the DEGs from the STRING database.…”

Section: Gse22818mentioning

confidence: 99%

Neuroprotective Properties of Photobiomodulation in Retinal Regeneration in Rats: Perspectives From Interaction Levels

et al. 2020

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Introduction: Photobiomodulation (PBM) is known as low-level laser (or light) therapy and is applied in different fields of medicine. However, it is required that its molecular and cellular mechanism be investigated. This study aims to assess the neuroprotective properties of PBM in the rat retina. Methods: GSE22818 was downloaded from Gene Expression Omnibus (GEO) and the regulation of the significant differentially expressed genes (DEGs) which are produced by light damage in the rat retina by the pretreatment of PBM application was assessed via network analysis and gene ontology enrichment. Results: The 78 produced DEGs by light-damage in the rat retina were protected via PBM pretreatment action. Among these determined DEGs, 53 individuals were included in the main connected component of the constructed protein-protein interaction (PPI) network. Ccl2, Icam1, Cxcl10, Timp1, and Fos were determined as hub nodes. Eight clusters including 26 regulated biochemical pathways by PBM pretreatment were identified. The critical DEGs based on the action maps were introduced. Conclusion: The finding indicates that PBM treatment protects rat retina against light damage via the prevention of Fos, Ccl2, Icam1, Cxcl10, and Myc dysregulation.

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The Impact of Proteomic Investigations on the Development and Improvement of Skin Laser Therapy: A Review Article

Cited by 6 publications

References 54 publications

Assessment of Laser Effects on Skin Rejuvenation

Assessment of Laser Effects on Skin Rejuvenation

Evaluation of Laser Effects on the Human Body After Laser Therapy

Neuroprotective Properties of Photobiomodulation in Retinal Regeneration in Rats: Perspectives From Interaction Levels

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