The Impact of Perioperative Blood Transfusion on Cancer Recurrence and Survival Following Radical Cystectomy

Linder, Brian J.; Frank, Igor; Cheville, John C.; Tollefson, Matthew K.; Thompson, R. Houston; Tarrell, Robert F.; Thapa, Prabin; Boorjian, Stephen A.

doi:10.1016/j.eururo.2013.01.004

Cited by 190 publications

(157 citation statements)

References 21 publications

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“…Previous study demonstrated that blood transfusion was associated with long-term survival in patients with resectable gastric cancer, and the relation was negatively impact (Kamei et al, 2009). And most studies demonstrated that perioperative blood transfusion increased cancer recurrence (Hyung et al, 2002;Linder et al, 2013). The intraoperative blood loss was lower in RG, which might improve the long term survival of patients who underwent RG.…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis of Outcomes Compared between Robotic and Laparoscopic Gastrectomy for Gastric Cancer

Liao

Xie²,

Li³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Meta-analysis of Outcomes Compared between Robotic and Laparoscopic Gastrectomy for Gastric Cancer

Liao

Xie²,

Li³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…Perioperative blood transfusion increases cancer recurrence and decreases patient survival after resection of primary malignancies [1,15,23,26]. It is unclear if the same is true for patients with cancer already disseminated to bone.…”

Section: Discussionmentioning

confidence: 99%

“…Perioperative allogeneic blood transfusion has been associated with tumor recurrence and decreased survival in patients with numerous primary malignancies, including colon, esophageal, hepatic, bladder, and endometrial cancers [1,15,23,26]. This detrimental effect of blood transfusion is explained by the immunomodulating effects of allogeneic blood transfusions [1,15,23,26].…”

Section: Introductionmentioning

confidence: 99%

“…This detrimental effect of blood transfusion is explained by the immunomodulating effects of allogeneic blood transfusions [1,15,23,26]. The immunomodulating effect was first hypothesized in 1973 in a study showing improved graft survival in patients who received allogeneic blood transfusion before kidney transplantation [19].…”

Section: Introductionmentioning

confidence: 99%

“…Blood loss during operative treatment of metastatic fractures can be substantial and blood transfusions frequently are administered [25]. Although studies suggest that transfusions increase the risk of metastasis and death [1,15,23,26], we do not know whether allogeneic blood transfusions influence survival in patients with already disseminated cancer.…”

Section: Introductionmentioning

confidence: 99%

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Are Allogeneic Blood Transfusions Associated With Decreased Survival After Surgery for Long-bone Metastatic Fractures?

Janssen

Braun

Ready

et al. 2015

Clinical Orthopaedics &Amp; Related Research

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Background Previous studies have shown that perioperative blood transfusion increases cancer recurrence and decreases patient survival after resection of primary malignancies. The question arises whether this association also exists in patients with already disseminated disease undergoing surgery for metastatic long-bone fractures. Purposes We sought to determine whether perioperative allogeneic blood transfusion is associated with decreased survival after operative treatment of long-bone metastatic fractures after accounting for clinical, laboratory, and treatment factors. Secondarily, we aimed to identify potential factors that are associated with decreased survival. Methods We included 789 patients in our retrospective study who underwent surgery at two institutions for a pathologic or impending metastatic long-bone fracture. We used multivariable Cox proportional hazards regression model analysis to assess the relationship of perioperative allogeneic blood transfusion with survival, and accounted for patient age, sex, comorbidities, BMI, tumor type, fracture type and location, presence of other bone and visceral metastases, previous radiotherapy and systemic therapy, preoperative embolization, preoperative hemoglobin level, treatment type, anesthesia time, blood loss, duration of hospital admission, year of surgery, and hospital. Results Considering transfusion as an ''exposure,'' and comparing patients who received transfusions with those who did not, we found that blood transfusion was not associated with decreased survival after accounting for all explanatory variables (hazard ratio [HR] 1.06; 95% CI, 0.87-1.30; p = 0.57). Evaluating transfusion in terms of dose-response, we found that patients who received more transfusions had lower survival compared with those who had fewer transfusions after accounting for all explanatory variables (HR per unit of blood transfused, 1.07; 95% CI, 1.02-1.12; p = 0.005). We found that age (HR, 1.02; 95%

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Predictive factors for perioperative blood transfusions in partial nephrectomy for renal masses

Abu-Ghanem

Dotan

Kaver

et al. 2015

Journal of Surgical Oncology

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The Impact of Perioperative Blood Transfusion on Cancer Recurrence and Survival Following Radical Cystectomy

Cited by 190 publications

References 21 publications

Meta-analysis of Outcomes Compared between Robotic and Laparoscopic Gastrectomy for Gastric Cancer

Meta-analysis of Outcomes Compared between Robotic and Laparoscopic Gastrectomy for Gastric Cancer

Are Allogeneic Blood Transfusions Associated With Decreased Survival After Surgery for Long-bone Metastatic Fractures?

Predictive factors for perioperative blood transfusions in partial nephrectomy for renal masses

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