The Impact of Palliative Radiation Therapy on Patients With Advanced Gastric Cancer: Results of a Retrospective Cohort Study

Katano, Atsuto; Yamashita, Hideomi

doi:10.7759/cureus.32971

Cited by 1 publication

(2 citation statements)

References 19 publications

(19 reference statements)

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“…Palliative radiotherapy (PRT) plays a pivotal role in endof-life care and is widely recognized for its efficacy in palliating symptoms caused by tumours, such as pain, bleeding and neurologic deficit. 1,2 However, a substantial number of patients die before experiencing symptom improvement. PRT administered to patients requires several time-consuming steps (interview with a doctor, simulation, planning and quality assurance).…”

Section: Introductionmentioning

confidence: 99%

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Thirty‐day mortality after palliative radiotherapy in advanced cancer patients: Optimizing end‐of‐life care in Asia

Kim,

Cha,

You

et al. 2024

J Med Imag Rad Onc

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IntroductionEvidence‐based guidelines recommend hypofractionated palliative radiotherapy (PRT); nonetheless, many patients receive prolonged course of PRT. To identify patients with limited benefits from PRT in end‐of‐life care, we evaluated the pattern of PRT at an Asian institution and factors associated with 30‐day mortality after PRT (30dM).MethodsWe retrospectively reviewed 228 patients who died after PRT in Yonsei Wonju Severance Christian hospital between October 2014 and March 2022. The associations between clinical factors and survival were assessed using the Cox proportional hazards method. Survival was analysed using the existing models to evaluate their performance in our cohort.ResultsThe median PRT duration was 13 (IQR, 7–15) days. Only 11.4% of the patients were treated with hypofractionated radiotherapy. One‐third of the patients (32.9%) could not complete PRT and 39 (17.1%) died during PRT. The 30dM was 31.6%. The median time from PRT to death was 17 (IQR, 11–23) days for the patients who died within 30 days. The number of involved organs (≤2 vs. >2; P < 0.001), albumin level (<3.3 vs. ≥3.3; P = 0.016), admission during PRT (P < 0.001), admission 3 months before PRT (P = 0.036) and ICU care during PRT (P < 0.001) were prognostic factors. A comparison of survival based on the existing models yielded unsatisfactory results in our cohort.ConclusionAlmost one‐third of the patients received PRT in the last 30 days of life. The use of hypofractionation for PRT was low in this Asian population. Further research is necessary to develop a predictive model of early mortality, allowing tailored end‐of‐life care for Asian patients.

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Section: Introductionmentioning

confidence: 99%

“…Palliative radiotherapy (PRT) plays a pivotal role in end‐of‐life care and is widely recognized for its efficacy in palliating symptoms caused by tumours, such as pain, bleeding and neurologic deficit 1,2 . However, a substantial number of patients die before experiencing symptom improvement.…”

Section: Introductionmentioning

confidence: 99%