The impact of oestrogenic and androgenic contamination on marine organisms in the United Kingdom—summary of the EDMAR programme

Matthiessen, Peter; Allen, Yvonne; Bamber, Shaw; Craft, John A.; Hurst, Mark R.; Hutchinson, Thomas H.; Feist, Steve; Katsiadaki, Ioanna; Kirby, Mark F.; Robinson, Craig D.; Scott, Sandy; Thain, John E.; Thomas, Kevin V.

doi:10.1016/s0141-1136(02)00135-6

Cited by 83 publications

(41 citation statements)

References 5 publications

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“…An abnormal structure of oocytes in vitellogenesis was reported for the amphipod G. pulex sampled at river sites where the natural steroids 17b-estradiol and estrone had been detected, together with male fish producing vitellogenin, a typical biomarker of exposure to estrogenic substances [116]. However, the cause of the pathologies in G. pulex is uncertain because, in the laboratory, crustaceans (crabs and shrimps) did not produce vitellin in response to estrogens [117]. Gefford et al [38] recently developed a reproductive toxicity test using the amphipod G. fossarum, encompassing molting, follicle growth, and embryonic development, to provide a better understanding of the effects of substances disrupting these processes.…”

Section: Effects Of Endocrine-disrupting Contaminants On Amphipodsmentioning

confidence: 99%

Review of the reproductive biology of amphipods and their endocrine regulation: Identification of mechanistic pathways for reproductive toxicants

Hyne¹

2011

Enviro Toxic and Chemistry

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Abstract-The reproductive biology of amphipods is reviewed to update the knowledge of the male and female reproductive processes of oogenesis and spermatogenesis as well as the endocrine systems of amphipods with the aim of advancing studies of reproductive toxicology. The ovarian and reproduction cycles of female gammaridean amphipods are closely correlated with the molt cycle, which is under direct control by the steroid hormone 20-hydroxyecdysone. The ability of males to copulate and subsequently for females to ovulate is restricted to the early postmolt period of the females. New developments in our understanding of the molt cycle and the endocrine regulatory pathways for reproduction using genomics techniques on other crustacean species are also discussed. The arthropod sterol ponasterone A or xenobiotics such as the fungicide fenarimol have been shown to elicit endocrine disruption in some crustaceans by acting as an agonist for 20-hydroxyecdysone at the ecdysone receptor or by inhibiting the synthesis of 20-hydroxyecdysone, respectively, resulting in disruption of molting and reproduction. Recent studies suggest that cadmium can inhibit secondary vitellogenesis in amphipods. Experimental approaches for examining the metabolic pathways associated with ecdysteroid hormonal signaling or metabolism, exoskeleton maintenance and molting, and the regulation of vitellogenin in amphipods are discussed. This information should aid in the identification of useful biomarkers for reproductive toxicity. Environ. Toxicol. Chem.

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Section: Effects Of Endocrine-disrupting Contaminants On Amphipodsmentioning

confidence: 99%

Review of the reproductive biology of amphipods and their endocrine regulation: Identification of mechanistic pathways for reproductive toxicants

Hyne¹

2011

Enviro Toxic and Chemistry

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“…Male flounders (Platichthys flesus) caught in industrialised estuaries of the UK and the Netherlands have been found with elevated concentrations of VTG in their plasma (Lye, Frid, Gill, & McCormick, 1997;Lye, Frid, & Gill, 1998;Allen et al, 1999a;Allen et al, 1999b;Matthiessen, Allen, Bamber, Craft, Hurst, Hutchinson et al, 2002;Vethaak, Lahr, Kuiper, Grinwis, Rankouhi, Giesy et al, 2002;Kirby, Allen, Dyer, Feist, Katsiadaki, Matthiessen et al, 2004;Kleinkauf, Scott, Stewart, Simpson, & Leah, 2004b;Kirby, Smith, Barry, Katsiadaki, Lyons, & Scott, 2006). The range of VTG concentrations was great (from <0.01 µg/ml to >50 x 10 3 µg/ml).…”

Section: Comparison With Previous Studies On Estrogenic Eds On Marinementioning

confidence: 99%

Evidence for estrogenic endocrine disruption in an offshore flatfish, the dab (Limanda limanda L.)

Scott

Sanders

Stentiford

et al. 2007

Marine Environmental Research

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“…Feminization of male fish has been reported in rivers of many regions (Matthiessen et al, 2002;Kolok et al, 2007;Xie et al, 2010). Vtgs are egg yolk precursor proteins in the serum of oviparous teleosts.…”

Section: Introductionmentioning

confidence: 99%

Regulation of reproduction- and biomarker-related gene expression by sex steroids in the livers and ovaries of adult female western mosquitofish (Gambusia affinis)

Huang

Ying

Liu

et al. 2012

Comparative Biochemistry and Physiology Part A: Molecular &

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The impact of oestrogenic and androgenic contamination on marine organisms in the United Kingdom—summary of the EDMAR programme

Cited by 83 publications

References 5 publications

Review of the reproductive biology of amphipods and their endocrine regulation: Identification of mechanistic pathways for reproductive toxicants

Review of the reproductive biology of amphipods and their endocrine regulation: Identification of mechanistic pathways for reproductive toxicants

Evidence for estrogenic endocrine disruption in an offshore flatfish, the dab (Limanda limanda L.)

Regulation of reproduction- and biomarker-related gene expression by sex steroids in the livers and ovaries of adult female western mosquitofish (Gambusia affinis)

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