The impact of multistrains of probiotics on Th17-related cytokines in patients with asthma: a randomized, double-blind, placebo-controlled trial

Sadrifar, Sina; Abbasi-Dokht, Tannaz; Forouzandeh, Sarvenaz; Malek, Farhad; Baharlou, Rasoul

doi:10.1080/02770903.2022.2144353

Cited by 6 publications

(3 citation statements)

References 46 publications

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“…Multiple studies have also shown Treg cell percentage and their suppressive activity were significantly decreased in SARS-CoV-2 patients [ 33 ]. It has been suggested that TNF-α and IL-6 could reduce suppressive activity in Tregs by preventing of TGF-β and FoxP3 expression [ 34 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

T-Cell Immune Responses and Immunological Factors Associated with Coronavirus Disease 2019 Progression as Predictors for the Severity of the Disease in Hospitalized Patients

Abbasi-Dokht¹,

Vafaeinezhad²,

Khalesi³

et al. 2023

Int Arch Allergy Immunol

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Introduction: The prevalence of coronavirus disease 2019 (COVID-19) has rapidly increased worldwide. More investigation is needed to progress toward understanding the exact role of immune responses in the pathology of the disease, leading to improved anticipation and treatment options. Methods: In the present study, we examined the relative expression of T-bet, GATA3, RORγt, and FoxP3 transcription factors as well as laboratory indicators in 79 hospitalized patients along with 20 healthy subjects as a control group. In order to make an exact comparison between various degrees of severity of disease, patients were divided into critical (n = 12) and severe (n = 67) groups. To evaluate the expression of genes of interest by performing real-time PCR, blood samples were obtained from each participant. Results: We found a significant increase in the expression of T-bet, GATA3, and RORγt and a reduction in the expression of FoxP3 in the critically ill patients compared to the severe and control groups. Also, we noticed that the GATA3 and RORγt expressions were elevated in the severe group in comparison with healthy subjects. Additionally, the GATA3 and RORγt expressions showed a positive correlation with elevation in CRP and hepatic enzyme concentration. Moreover, we observed that the GATA3 and RORγt expressions were the independent risk factors for the severity and outcome of COVID-19. Discussion: The present study showed that the overexpression of T-bet, GATA3, and RORγt, as well as a decrease in the FoxP3 expression was associated with the severity and fatal outcome of COVID-19.

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Section: Discussionmentioning

confidence: 99%

T-Cell Immune Responses and Immunological Factors Associated with Coronavirus Disease 2019 Progression as Predictors for the Severity of the Disease in Hospitalized Patients

Abbasi-Dokht¹,

Vafaeinezhad²,

Khalesi³

et al. 2023

Int Arch Allergy Immunol

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“…93 Supplementation with a probiotic mixture of multiple Lactobacilli, B. longum, and Streptococcus thermophilus in adults with asthma resulted in an improvement of lung function, a reduction in several inflammatory markers and an increase in regulatory markers. [94][95][96] However, in longitudinal studies, supplementation with L. reuteri, L. rhamnosus, or B. lactis or a mix of Lactobacilli and Bifidobacteria to pregnant women in the last month of pregnancy, 3-6 months postpartum, and after birth to their newborns till 6 months to 2 years of age did not induce a difference in asthma incidence at school age. [97][98][99][100] In conclusion, the in vivo interventions described above only seem to influence asthma symptoms in children above 3 years and adults and do not prevent asthma development, when given during pregnancy and in newborns.…”

Section: Interventi On S Tud Ie Smentioning

confidence: 91%

“…A study in which 3–14 years old asthmatics were supplemented with a mixture of Lactobacillus and Bifidobacterium for 16 weeks found a reduction in asthma exacerbations 93 . Supplementation with a probiotic mixture of multiple Lactobacilli, B. longum , and Streptococcus thermophilus in adults with asthma resulted in an improvement of lung function, a reduction in several inflammatory markers and an increase in regulatory markers 94–96 . However, in longitudinal studies, supplementation with L. reuteri, L. rhamnosus , or B. lactis or a mix of Lactobacilli and Bifidobacteria to pregnant women in the last month of pregnancy, 3–6 months postpartum, and after birth to their newborns till 6 months to 2 years of age did not induce a difference in asthma incidence at school age 97–100 …”

Section: Intervention Studiesmentioning

confidence: 99%

Influence of the gut and airway microbiome on asthma development and disease

Smulders,

Van Der Schee,

Maitland‐Van Der Zee

et al. 2024

Pediatric Allergy Immunology

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There are ample data to suggest that early‐life dysbiosis of both the gut and/or airway microbiome can predispose a child to develop along a trajectory toward asthma. Although individual studies show clear associations between dysbiosis and asthma development, it is less clear what (collection of) bacterial species is mechanistically responsible for the observed effects. This is partly due to issues related to the asthma diagnosis and the broad spectrum of anatomical sites, sample techniques, and analysis protocols that are used in different studies. Moreover, there is limited attention for potential differences in the genetics of individuals that would affect the outcome of the interaction between the environment and that individual. Despite these challenges, the first bacterial components were identified that are able to affect the transcriptional state of human cells, ergo the immune system. Such molecules could in the future be the basis for intervention studies that are now (necessarily) restricted to a limited number of bacterial species. For this transition, it might be prudent to develop an ex vivo human model of a local mucosal immune system to better and safer explore the impact of such molecules. With this approach, we might move beyond association toward understanding of causality.

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The potential protective effects of probiotics, prebiotics, or yogurt on chronic obstructive pulmonary disease: Results from NHANES 2007–2012

Hong,

Luo

2024

Food Science & Nutrition

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Chronic obstructive pulmonary disease (COPD) ranks among the world's three leading causes of mortality, owing to the increased smokers and aging populations. Previous studies showed that gut microbiota could help to ameliorate respiratory diseases. Hence, the current study aims to evaluate the effects of probiotics, prebiotics, or yogurt on the prevalence of COPD. A cross‐sectional study was carried out by investigating data from three consecutive NHANES cycles during 2007–2012. Individuals who met the inclusion and exclusion criteria were studied. Prescription medications and dietary were reviewed to identify the intake of probiotics, prebiotics, or yogurt. The included participants were then divided into two groups depending on their consumption of probiotics, prebiotics, or yogurt. Multivariate logistic regression analysis was conducted to analyze the effects of probiotics, prebiotics, or yogurt consumption on the prevalence of COPD. Out of 7486 enrolled participants, 1656 (22.12%) were categorized into the probiotics, prebiotics, or yogurt intake group. This study indicated that consuming probiotics, prebiotics, or yogurt were correlated with a lower incidence of COPD, even when factors like gender, age, education, moderate‐intensity activities, vigorous activities, hypertension, asthma, diabetes, smoking and alcohol consumption were accounted for (Model 1: OR, 0.68, 95% CI, 0.53–0.87; Model 2: OR, 0.77, 95% CI, 0.59–0.99; Model 3: OR, 0.75, 95% CI, 0.57–0.98). The findings reveal that consuming probiotics, prebiotics, or yogurt might play a beneficial role in preventing COPD.

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The impact of multistrains of probiotics on Th17-related cytokines in patients with asthma: a randomized, double-blind, placebo-controlled trial

Cited by 6 publications

References 46 publications

T-Cell Immune Responses and Immunological Factors Associated with Coronavirus Disease 2019 Progression as Predictors for the Severity of the Disease in Hospitalized Patients

T-Cell Immune Responses and Immunological Factors Associated with Coronavirus Disease 2019 Progression as Predictors for the Severity of the Disease in Hospitalized Patients

Influence of the gut and airway microbiome on asthma development and disease

The potential protective effects of probiotics, prebiotics, or yogurt on chronic obstructive pulmonary disease: Results from NHANES 2007–2012

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