The impact of humic acid additives on mineral metabolism of rabbits in the postnatal period of ontogenesis

Rybalka, M. A.; Stepchenko, L. M.; Shuleshko, O. O.; Zhorina, L. V.

doi:10.15421/022043

Cited by 4 publications

(5 citation statements)

References 33 publications

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“…In HS-added rabbits, an early increased content of Fe and Ca and late increased activity of ALP and Cu content in serum were observed; additionally, in HS-added rabbits, increased number of layers of osteons and osteoblasts in the bone tissue of the femur, number of osteons and osteoblasts in the bone tissue of the sternum, number of columns of chondrocytes, and number of chondrocytes in the column in the cartilaginous tissue of the sternum were found [124].…”

Section: Mineralsmentioning

confidence: 93%

Mechanisms of Action of Humic Substances as Growth Promoters in Animals

Angeles¹,

Gómez-Rosales²,

Téllez–Isaías³

2022

Humus and Humic Substances - Recent Advances

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A review of the latest research on the addition of humic substances (HSs) in the drinking water or feed of farm animals including poultry, pigs, dairy cows and calves, goats, and rabbits was carried out. The results reinforces the promoted protective action of HS on the digestive mucosa, their antioxidant properties, immunomodulatory, and anti-inflammatory attributes, the suggested microbial shift to a probiotic-type bacteria in the gut, including antiparasitic and antifungal effects, as well as their influence on the higher efficient of minerals, proteins, and lipids utilization within the body. The outstanding improvements in health, productivity, and meat and milk quality obtained from animals supplemented with HS are common features in the majority of available research. The main benefits in the gastrointestinal tract stem from the formation of protective barriers on the epithelial mucosa due to its colloidal properties and stimulation of mucin production. HS also promotes the development of probiotic microbiota and positive changes in bacterial fermentation patterns, which results in improved intestinal health and integrity. As a result, a cascade of benefits is derived within the body, reinforcing antioxidant protection responses, immunomodulation, and anti-inflammation mechanisms, as well as improving nutrient utilization efficiency. However, the truly molecular mechanisms of action of HS in the intestine and throughout the body remain unknown.

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Section: Mineralsmentioning

confidence: 93%

Mechanisms of Action of Humic Substances as Growth Promoters in Animals

Angeles¹,

Gómez-Rosales²,

Téllez–Isaías³

2022

Humus and Humic Substances - Recent Advances

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“…It has also been proposed that HS can cause intestinal morphophysiological changes, stimulate changes in intracellular divalent calcium levels, and act as dilators, increasing mucosal and cellular permeability (Pizzari & Birkhead, 2000;Johnsson et al, 2015). Increased gut permeability, and thus cell membrane permeability in the body, may facilitate mineral assimilation and transfer from blood to bone and cells, resulting in better skeletal development (Dinev, 2012;Jad'uttová et al, 2019;Rybalka et al, 2020). These suggestions are supported by improved digestive capabilities such as increased intestinal villus height and width (Taklimi et al, 2012;Disetlhe et al, 2017;Lala et al, 2017), improved tibia ash and Ca content (Eren et al, 2000;Jad'uttová et al, 2019), and higher meat mineral concentrations, such as Ca, Fe and Cu (Ozturk et al, 2010;Ozturk et al, 2012) of broilers supplemented with HS.…”

Section: Growth Performance and Tibia Mineralization Of Broiler Chick...mentioning

confidence: 99%

Growth Performance and Tibia Mineralization of Broiler Chickens Supplemented with a Liquid Extract of Humic Substances

Angeles¹,

Gómez-Rosales²,

López-Garcia

et al. 2022

Braz. J. Poult. Sci.

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The objective of the study was to evaluate the productive, carcass, and tibia mineralization responses in broiler chickens supplemented with a liquid extract of humic substances (HS) in the drinking water. Chicks were housed in holding cages from 8-42 days of age and were randomly assigned to one of five increasing HS levels in the drinking water (0, 161, 322, 483, and 644 µg/L). At 21 and 42 days, to obtain carcass and tibia measurements half of the broilers were slaughtered. ANOVA and linear regression were used to analyze the data. The HS chemical composition and flat structures were estimated. At 21 days, increasing levels of HS in the drinking water resulted in a cubic response on breast weight (p<0.05), tibia ashes percentage (p<0.05) and tibia Ca percentage, as well as a linear increasing response (p<0.05) on P percentage. HS elicited a quadratic response on the tibia DM percentage (p<0.05), Ca content (p<0.01), and P content (p<0.05) at 42 days.The optimal HS supplementation level to achieve the highest tibia DM percentage, Ca and P content were 345.00, 322.46, and 347.75 µg/L, respectively. Increasing HS levels also resulted in a cubic response in tibia Ca (p<0.05) and P percentage (p<0.01). In conclusions, HS supplementation in drinking water improved bone mineralization in broiler chickens at 21 and 42 days of age.

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“…They demonstrated the ability of humic acid to increase the content of calcium, ionized calcium, and iron, and adjust the content of copper and zinc, as well as increase the activity of alkaline phosphatase in the blood serum of rabbits. They also observed an early effect of humic acid supplementation on an increase in the content of ionized iron and calcium, as well as a later effect on the activity of al-kaline phosphatase and an increase in the content of copper in blood serum; on the distribution of calcium, phosphorus, manganese, copper, and zinc in bone tis-sue [26].…”

Section: Discussionmentioning

confidence: 88%

“…The ability of humic acids to influence mineral metabolism in animals due to the presence of chelating properties was reported by Rybalka et al (2020). They demonstrated the ability of humic acid to increase the content of calcium, ionized calcium, and iron, and adjust the content of copper and zinc, as well as increase the activity of alkaline phosphatase in the blood serum of rabbits.…”

Section: Discussionmentioning

confidence: 93%

Effect of Humic Feed Additive on Metabolic Processes and Productivity of Beef Cattle

Kukhar,

Yermagambet,

Kassenova

2023

KAZATUVC

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The use of made in Kazakhstan organic and mineral feed additives to in-crease the meat productivity of cattle is important for the agro-industrial complex of the Republic. During the study, qualitative and quantitative analysis of raw materials was made. Quality control of the finished feed additive was carried out following the requirements of the State Pharmacopoeia of the Republic of Kazakhstan. The studies were conducted in accordance with the requirements of the Technical Regulations approved by the Decree of the Government of the Republic of Kazakhstan dated April 23, 2008 No. 380, Regulation No. 7-1/625 dated 11/28/2014 and Regulation (EC) No. 1831/2003 of the European Parliament and of the Council of September 22, 2003, on additives for use in animal feeding. Kazakh potassium humate of the Maykubensky deposit is sterile, non-pyrogenic, non-toxic, and harmless, with an average pH of 11.0-1.0, and has a biological effect on laboratory animals (white mice). The effectiveness analysis in the production experiment allowed us to identify the positive effect of feed additives on metabolic processes and increasing meat productivity in bulls. Regardless of age, on the 7th day of taking the feed additive of potassium humate, the calves' coats acquired a noticeable shine and a bright color, and shedding was completed with-in a month. Clinical signs of metabolic disorders and vitamin deficiency, detected in the farm at the time of the experiment in some animals, pass through 20-30 days from the beginning of the application of the feed additive. The optimal scheme for the use of feed additives was tested on the Kazakh meat breed Akbas, and the concentration of humic substances was selected for the maximum mani-festation of the biologically active effect. Animals became mobile and active, their rumination became more active, they grew noticeably, and the average daily weight gain increased by 7.6-8.9%.

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The impact of humic acid additives on mineral metabolism of rabbits in the postnatal period of ontogenesis

Cited by 4 publications

References 33 publications

Mechanisms of Action of Humic Substances as Growth Promoters in Animals

Mechanisms of Action of Humic Substances as Growth Promoters in Animals

Growth Performance and Tibia Mineralization of Broiler Chickens Supplemented with a Liquid Extract of Humic Substances

Effect of Humic Feed Additive on Metabolic Processes and Productivity of Beef Cattle

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