The impact of HLA-E polymorphisms on relapse following allogeneic hematopoietic stem cell transplantation

Hosseini, Ehteramolsadat; Schwarer, Anthony P.; Jalali, Arash; Ghasemzadeh, Mehran

doi:10.1016/j.leukres.2013.01.011

Cited by 33 publications

(38 citation statements)

References 26 publications

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“…This further confirms the existence of weak linkage disequilibrium between the classical HLA and HLA-E loci [59]. In HLA-E-matched allogeneic HSCT, the HLA-E*01:03/01:03 homozygous genotype has a protective role since it is associated with a lower frequency of acute and chronic GvHD, and it is associated with improved overall survival compared with other HLA-E genotypes [66,67]. Therefore, lower HLA-E expression on allograft-associated with the HLA-E*01:01 homozygous state [19] may lead to complications such as GvHD because the recipient may be less capable of inhibiting immune cells through CD94/ NKG2A receptors.…”

Section: Hla-ib In Graft-versus-host Diseasesupporting

confidence: 71%

“…Therefore, HLA-E*01:03 homozygous recipients may be better graft "acceptors" than HLA-E*01:01 patients provided that the allograft is devoid of viremia. Withal, a HLA-E genotype match should be beneficial in transplantation because the HLA-E homozygous state has been shown to be associated with transplantation outcomes, especially in BMT and HSCT [59,66,67].…”

Section: Hla-ib: Role In Histocompatibilitymentioning

confidence: 99%

See 1 more Smart Citation

Immunobiology of HLA Class-Ib Molecules in Transplantation

Jucaud¹

2015

SOJI

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Section: Hla-ib In Graft-versus-host Diseasesupporting

confidence: 71%

Section: Hla-ib: Role In Histocompatibilitymentioning

confidence: 99%

Immunobiology of HLA Class-Ib Molecules in Transplantation

Jucaud¹

2015

SOJI

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“…However, HLA‐E*01:03 homozygosity was associated with a lower frequency of acute‐ and chronic GvHD and with improved survival. The same authors describe in a second study a lower incidence of relapse and improved disease free survival in HLA‐E*01:03,01:03 patients as compared with patients having either one of the other two genotypes . Thus far only one published study showed that the HLA‐E genotype did not have any influence on allo‐SCT outcome .…”

Section: Hla‐e In Allogeneic Hematopoietic Stem Cell Transplantationmentioning

confidence: 89%

Clinical and immunological significance of HLA‐E in stem cell transplantation and cancer

et al. 2014

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Human leukocyte antigen-E (HLA-E) is a nonclassical HLA class I molecule that canonically binds peptides derived from the leader sequence of classical HLA class I. HLA-E can also bind peptides from stress protein [e.g. heat shock protein 60 (Hsp60)] and pathogens, illustrating the importance of HLA-E for anti-viral and anti-tumor immunity. Like classical HLA class I molecules, HLA-E is ubiquitously expressed, however, it is characterized by only a very limited sequence variability and two dominant protein forms have been described (HLA-E*01:01 and HLA-E*01:03). HLA-E influences both the innate and the adaptive arms of the immune system by the engagement of inhibitory (e.g. NKG2A) and activating receptors [e.g. αβ T cell receptor (αβTCR) or NKG2C] on NK cells and CD8 T cells. The effects of HLA-E on the cellular immune response are therefore complex and not completely understood yet. Here, we aim to provide an overview of the immunological and clinical relevance of HLA-E and HLA-E polymorphism in stem cell transplantation and in cancer. We review novel insights in the mechanism via which HLA-E expression levels are controlled and how the cellular immune response in transplantation and cancer is influenced by HLA-E.

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“…A major limitation of previous studies is that they sequenced only a few exons or used genotyping methods to detect known HLA-E polymorphisms [14,17,18,[23][24][25][26][27][28][29][30]. Even in the Brazilian population [18], which represents the most comprehensively studied sample for HLA-E at the moment, only exons 1-4, in addition to the 3 0 UTR were sequenced.…”

Section: Introductionmentioning

confidence: 99%