The Impact of Gonadal Steroid Hormone Action on Growth Hormone Secretion During Childhood and Adolescence*

Kerrigan, James R.; Rogol, Alan D.

doi:10.1210/edrv-13-2-281

Cited by 107 publications

(77 citation statements)

References 168 publications

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“…Bass et al find that serum IGF-1 levels increase by over 2-fold from puberty to menarche -the period of rapid skeletal growth -and then remain relatively constant until linear growth is terminated by epiphyseal plate closure. Their data, along with those of others (5, 7), suggest that an increase in serum IGF-1, stimulated by growth hormone (7) and sex steroids (8), is the major facilitator of increases in bone size during puberty. Also, serum estradiol correlated inversely with biochemical markers for bone turnover, consistent with the antiresorptive action of estrogen.…”

mentioning

confidence: 61%

The assembly of the adult skeleton during growth and maturation: implications for senile osteoporosis

Riggs

Khosla²,

Melton³

1999

J. Clin. Invest.

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mentioning

confidence: 61%

The assembly of the adult skeleton during growth and maturation: implications for senile osteoporosis

Riggs

Khosla²,

Melton³

1999

J. Clin. Invest.

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“…In rodents, hypophysectomy abolishes sex-dependent differences in HCC 87 . Estrogen can modulate growth hormone signaling acting on pituitary GH secretion 88 , as well as on control of GH receptor (GHR) expression 89 . GH in turn targets the liver in a sexspecific manner, which is particularly evident in rodents at puberty, but is also found in humans 90 .…”

Section: Sex Hormone Signaling In Specific Cancer Typesmentioning

confidence: 99%

Sexual dimorphism in cancer

et al. 2016

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The incidence of many cancer types is significantly higher in the male than female populations, with associated differences in survival. Occupational and/or behavioral factors are well known underlying determinants. However, cellular/molecular differences between the two sexes are also likely to be important. We are focusing here on the complex interplay that sexual hormones and sex chromosomes can have in intrinsic control of cancer initiating cell populations, tumor microenvironment and systemic determinants of cancer development like the immune system and metabolism. A better appreciation of these differences between the two sexes could be of substantial value for cancer prevention as well as treatment.3 Introduction (Epidemiology)

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“…Administration of exogenous testosterone or pulsed gonadotrophin-releasing hormone in primary or hypogonadotrophic hypogonadism increases spontaneous and stimulated GH secretion and the disorderliness of secretion. However, use of non-aromatisable androgens in hypogonadal boys does not alter GH dynamics, implying that the testosterone effect requires aromatisation to oestrogen (Kerrigan & Rogol 1992, Veldhuis et al 1997. This oestrogen effect is believed to be at a central level as testosterone stimulates increased GH secretion and, in parallel, increased IGF1 production.…”

Section: External Regulators Of the Central Gh Axismentioning

confidence: 99%

60 YEARS OF NEUROENDOCRINOLOGY: The hypothalamo-GH axis: the past 60 years

Murray¹,

Higham²,

Clayton³

2015

Journal of Endocrinology

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At the time of the publication of Geoffrey Harris's monograph on 'Neural control of the pituitary gland' 60 years ago, the pituitary was recognised to produce a growth factor, and extracts administered to children with hypopituitarism could accelerate growth. Since then our understanding of the neuroendocrinology of the GH axis has included identification of the key central components of the GH axis: GH-releasing hormone and somatostatin (SST) in the 1970s and 1980s and ghrelin in the 1990s. Characterisation of the physiological control of the axis was significantly advanced by frequent blood sampling studies in the 1980s and 1990s; the pulsatile pattern of GH secretion and the factors that influenced the frequency and amplitude of the pulses have been defined. Over the same time, spontaneously occurring and targeted mutations in the GH axis in rodents combined with the recognition of genetic causes of familial hypopituitarism demonstrated the key factors controlling pituitary development. As the understanding of the control of GH secretion advanced, developments of treatments for GH axis disorders have evolved. Administration of pituitary-derived human GH was followed by the introduction of recombinant human GH in the 1980s, and, more recently, by long-acting GH preparations. For GH excess disorders, dopamine agonists were used first followed by SST analogues, and in 2005 the GH receptor blocker pegvisomant was introduced. This review will cover the evolution of these discoveries and build a picture of our current understanding of the hypothalamo-GH axis.

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The Impact of Gonadal Steroid Hormone Action on Growth Hormone Secretion During Childhood and Adolescence*

Cited by 107 publications

References 168 publications

The assembly of the adult skeleton during growth and maturation: implications for senile osteoporosis

The assembly of the adult skeleton during growth and maturation: implications for senile osteoporosis

Sexual dimorphism in cancer

60 YEARS OF NEUROENDOCRINOLOGY: The hypothalamo-GH axis: the past 60 years

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