The impact of glycemic variability in the progression of renal disease in diabetic patients treated with insulin therapy

Pereira, Santos; Barros, Jat; Salgueiro, Andréia Caroline Fernandes; Cardoso, Nuno; Esteves, Mário; Salomão, Joab Oliveira; Silva, D.; Duarte, Amélia Stival

doi:10.1016/j.mei.2016.01.006

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…The quality scores ranged from 4 to 9. Pereira et al [18] was excluded as it was considered to be of poor quality for the following reasons (quality score 4): a small sample size (n = 221); the exclusion of participants with additional comorbidities, which may have a biased sampling from the population of people with diabetes; inadequate follow-up; high attrition bias (221/538); and a failure to adjust for potential confounders (covariates such as age and diabetes duration). No robust statistical analyses were conducted to compare the association glycaemic variability and renal outcome.…”

Section: Quality Appraisalmentioning

confidence: 99%

The Association Between Glycaemic Variability and Progression of Chronic Kidney Disease: a Systematic Review

Habte-Asres

Wheeler

Forbes

2022

SN Compr. Clin. Med.

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The study aims to evaluate the association between glycaemic variability and the risk of chronic kidney disease (CKD) progression in patients with diabetes and comorbid kidney disease. A comprehensive search was conducted of three databases from their inception to March 2022: Medline, Embase, and CINHAL. Publications were screened for eligibility and the quality of studies included was appraised using the Newcastle–Ottawa Scale. Extracted data were tabulated and reported in a narrative synthesis. Fourteen studies were included in the review providing data on 62,498 participants. Eight studies reported that greater glycaemic variability was associated with an increased incidence of CKD. Three studies reported an increased likelihood of CKD progression in those with high glycaemic variability, although the rate and risk of progression varied across the studies. Three studies reported an increased risk of progression to end-stage kidney disease (ESKD) with higher glycaemic variability. One study found that high glycaemic variability was associated with a decreased risk of progression to ESKD. Greater glycaemic variability was associated with the onset and progression of CKD. More research is required to verify whether glycaemic variability increases the risk of progression to ESKD in patients with diabetes and mild/moderate comorbid CKD.

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Section: Quality Appraisalmentioning

confidence: 99%

The Association Between Glycaemic Variability and Progression of Chronic Kidney Disease: a Systematic Review

Habte-Asres

Wheeler

Forbes

2022

SN Compr. Clin. Med.

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Glycemic variability in patients with diabetes mellitus and different stages of diabetic nephropathy

Волкова

Mozgunova

Chernaya

et al. 2020

Nefrologiâ (St.-Peterbg.)

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The relevance of the study of glycemic variability in patients with diabetes mellitus and diabetic nephropathy is due to disability of the able-bodied population and high mortality against the background of the almost irreversible progression of diabetic nephropathy. The article highlights modern ideas about the influence of various factors on the occurrence of diabetic nephropathy and its course. The article is devoted to a review of current recommendations on diabetes mellitus and diabetic nephropathy; the etiopathogenesis of diabetic nephropathy was described in detail. The role of the kidneys in glucose homeostasis, renal gluconeogenesis, and glucose reabsorption by the kidneys in healthy and in pathology is described. Detailed expositions of glycemic variability parameters, their changes in patients with diabetes mellitus depending on the stage of diabetic kidney damage are presented. The role of the kidneys in maintaining energy homeostasis, impaired glucose homeostasis in conditions of chronic kidney disease is described. We analyzed different options for insulin therapy, their advantages, and disadvantages in patients with diabetes mellitus with diabetic nephropathy. The presented material is extremely relevant for the development and implementation in the clinical practice of glycemic control methods to optimize treatment tactics, prevent the formation of microvascular complications, and early disability of patients with diabetes mellitus.

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The impact of glycemic variability in the progression of renal disease in diabetic patients treated with insulin therapy

Cited by 2 publications

References 12 publications

The Association Between Glycaemic Variability and Progression of Chronic Kidney Disease: a Systematic Review

The Association Between Glycaemic Variability and Progression of Chronic Kidney Disease: a Systematic Review

Glycemic variability in patients with diabetes mellitus and different stages of diabetic nephropathy

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