The impact of ghrelin on oxidative stress and inflammatory markers on the liver of diabetic rats

Elsawy, Mahmoud; Emara, Elsayed A.

doi:10.4103/1110-1415.201723

Cited by 8 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the current study, diabetic rats' levels of malondialdehyde, lactate dehydrogenase, tumor necrosis factor alpha, interleukin 1 and also interleukin 6 dramatically rise as compared to normal, along with a significant drop in catalase. These findings corroborated those of Elsawy and Emara (18) who claimed that increased levels of proinflammatory cytokines, such as interleukin 1, interleukin 6, malondialdehyde, and tumour necrosis factor alpha, were brought on by elevated oxidative stress or a decline in antioxidant defence mechanisms in diabetes mellitus.…”

Section: Discussionsupporting

confidence: 88%

Impact of Betanin on Diabetes Induced Experimentally by Streptozotocin and Associated Histopathological Changes in Albino Adult Rats

2023

The Egyptian Journal of Hospital Medicine

View full text Add to dashboard Cite

Background:The endocrine problem diabetes mellitus is the most prevalent condition. Over time, the heart and blood arteries become among the tissues and organs that are negatively impacted by this medical disease. Beets' antiinflammatory, antioxidant, anti-tumor, high pressure-lowering, neuroprotective, and immune-modulating advantages are equivalent to those of pharmaceuticals. Aim of the work: Analyzing the effects of betanin on experimentally generated diabetes and related Histopathological Alteration in Adult Albino Rats. Material and Methods: Rattus norvegicus albino adult males were separated into four equal groups, as follows: Group I functioned as the control group, Group II was the diabetic group, Group III was the normal plus betanin, and Group IV was the diabetic group that had been given betanin therapy. The samples of blood have been collected at the completion of the study's period to be investigated blood glucose levels, glycated haemoglobin, serum insulin, alanine amino transferase (ALT), aspartate amino transferase (AST), lipid profiles, malondialdehyde (MDA), tumour necrosis factor alpha (TNFα), catalase, nuclear factor Kapp, lactate dehydrogenase, interleukin 1 and interleukin 6. Additionally, liver and pancreas samples were taken for a histopathology investigation. Results: The drug streptozotocin (STZ) substantially increased levels of blood sugar, glycated haemoglobin, cholesterol, alanine amino transferase, aspartate amino transferase, malondialdehyde, TNF, lactate dehydrogenase, nuclear factor kappa, IL-1, and IL-6 while substantially reducing levels of serum insulin and catalase. All levels substantially improved after receiving betanin treatment. Conclusion: Due to its antioxidant properties, betanin has a preventive impact on diabetic rats.

show abstract

Section: Discussionsupporting

confidence: 88%

Impact of Betanin on Diabetes Induced Experimentally by Streptozotocin and Associated Histopathological Changes in Albino Adult Rats

2023

The Egyptian Journal of Hospital Medicine

View full text Add to dashboard Cite

show abstract

“…In the present DN experimental model, STZ injection produced a significant increase in TNF-α and Il-6. Hyperglycemia may trigger inflammatory process elevating proinflammatory cytokines, IL-6 and TNF-α, expression, possibly due to ROS production [50] or reduction of antioxidant defense systems [51,52]. Glimepiride or both doses D. salina administration after STZ treatment resulted in lower serum levels of IL-6 and TNF-α when compared with the diabetic group.…”

Section: Discussionmentioning

confidence: 99%

Dunaliella salina Attenuates Diabetic Neuropathy Induced by STZ in Rats: Involvement of Thioredoxin

El-Baz

Salama

2020

BioMed Research International

View full text Add to dashboard Cite

Diabetic neuropathy (DN) is a widespread disabling disorder including peripheral nerves’ damage. The aim of the current study was to estimate the potential ameliorative effect of Dunaliella salina (D. salina) on DN and the involvement of the thioredoxin. Diabetes was induced by streptozotocin (STZ; 50 mg/kg; i.p). Glimepiride (0.5 mg/kg) or D. salina powder (100 or 200 mg/kg) were given orally, after 2 days of STZ injection for 4 weeks. Glucose, total antioxidant capacity (TAC), superoxide dismutase (SOD), and catalase (CAT) serum levels as well as brain contents of thioredoxin (Trx), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) were measured with the histopathological study. STZ-induced DN resulted in a significant (P<0.05) rise in glucose blood level and brain contents of TNF-α and IL-6 and produced a reduction in serum TAC, SOD, CAT, and brain Trx levels with irregular islets of Langerhans cells and loss of brain Purkinje cells. Treatment with glimepiride or both doses of D. salina alleviated these biochemical and histological parameters as compared to the STZ group. D. salina has a neurotherapeutic effect against DN via its inhibitory effect on inflammatory mediators and oxidative stress molecules with its upregulation of Trx activity.

show abstract

“…Interestingly, the impact of DAG on oxidative stress and inflammation was reported in the liver of diabetic rats [62]. In this study, the administration of DAG in a diabetic animal model counteracts all diabetogenic effects of streptozotocin.…”

Section: Antioxidant and Protective Effect Related To Hepatic Tissuementioning

confidence: 50%

Potentiality of ghrelin as antioxidant and protective agent

2021

View full text Add to dashboard Cite

Background: Oxidative stress is the result of cellular troubles related to aerobic metabolism. Furthermore, this stress is always associated with biological responses evoked by physical, chemical, environmental, and psychological factors. Several studies have developed many approaches of antioxidant defense to diminish the severity of many diseases. Ghrelin was originally identified from the rat stomach, and it is a potent growth hormone-releasing peptide that has pleiotropic functions. Methods: A systematic review was conducted within PubMed, ScienceDirect, MEDLINE, and Scopus databases using keywords such as ghrelin, antioxidant, oxidative stress, and systemic oxidative stress sensor. Results: In the last decade, many studies show that ghrelin exhibits protection effects against oxidative stress derived probably from its antioxidant effects. Pieces of evidence demonstrate that systemic oxidative stress increase ghrelin levels in the plasma. The expression of ghrelin and its receptor in ghrelin peripheral tissues and extensively in the central nervous system suggests that this endogenous peptide plays an important role as a systemic oxidative stress sensor Conclusion: The current evidence confirms that ghrelin and its derived peptides (Desacyl-ghrelin, obestatin) act as a protective antioxidant agent. Therefore, stressor modality, duration, and intensity are the parameters of oxidative stress that must be taken into consideration to determine the role of ghrelin, Desacyl-ghrelin, and obestatin in the regulation of cell death pathways.

show abstract

The impact of ghrelin on oxidative stress and inflammatory markers on the liver of diabetic rats

Cited by 8 publications

References 0 publications

Impact of Betanin on Diabetes Induced Experimentally by Streptozotocin and Associated Histopathological Changes in Albino Adult Rats

Impact of Betanin on Diabetes Induced Experimentally by Streptozotocin and Associated Histopathological Changes in Albino Adult Rats

Dunaliella salina Attenuates Diabetic Neuropathy Induced by STZ in Rats: Involvement of Thioredoxin

Potentiality of ghrelin as antioxidant and protective agent

Contact Info

Product

Resources

About