The Impact of Early Regular Cardiac Rehabilitation Program on Myocardial Function after Acute Myocardial Infarction

Kim, Chul; Kim, Duk You; Lee, Dong Woo

doi:10.5535/arm.2011.35.4.535

Cited by 20 publications

(19 citation statements)

References 17 publications

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“…However, it is unclear to what extent the hypertrophic response in the MI-runner group represented an adaptive or maladaptive response, since LV systolic function was not altered by MI, which limits the conclusions about adaptive and maladaptive hypertrophy. These observations concur with previous studies investigating the effect of exercise after MI on the hypertrophic response in rodents (13,14,33) and humans (21,32,56). In contrast, Rengo et al (62) documented increased LV hypertrophy after 10-wk endurance training after MI in mice.…”

Section: H351 Exercise Limits Post-mi Scar Thinningsupporting

confidence: 90%

Exercise attenuates inflammation and limits scar thinning after myocardial infarction in mice

Puhl

Müller

Wagner

et al. 2015

American Journal of Physiology-Heart and Circulatory Physiology

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Although exercise mediates beneficial effects in patients after myocardial infarction (MI), the underlying mechanisms as well as the question of whether an early start of exercise after MI is safe or even beneficial are incompletely resolved. The present study analyzed the effects of exercise before and reinitiated early after MI on cardiac remodeling and function. Male C57BL/6N mice were housed sedentary or with the opportunity to voluntarily exercise for 6 wk before MI induction (ligation of the left anterior descending coronary artery) or sham operation. After a 5-day exercise-free phase after MI, mice were allowed to reexercise for another 4 wk. Exercise before MI induced adaptive hypertrophy with moderate increases in heart weight, cardiomyocyte diameter, and left ventricular (LV) end-diastolic volume, but without fibrosis. In sedentary mice, MI induced eccentric LV hypertrophy with massive fibrosis but maintained systolic LV function. While in exercised mice gross LV end-diastolic volumes and systolic function did not differ from sedentary mice after MI, LV collagen content and thinning of the infarcted area were reduced. This was associated with ameliorated activation of inflammation, mediated by TNF-␣, IL-1␤, and IL-6, as well as reduced activation of matrix metalloproteinase 9. In contrast, no differences in the activation patterns of various MAPKs or adenosine receptor expressions were observed 5 wk after MI in sedentary or exercised mice. In conclusion, continuous exercise training before and with an early reonset after MI ameliorates adverse LV remodeling by attenuating inflammation, fibrosis, and scar thinning. Therefore, an early reonset of exercise after MI can be encouraged. exercise; remodeling; scar thinning; magnetic resonance imaging; fibrosis; myocardial infarction NEW & NOTEWORTHY Our data provide new insights into the exercise-mediated cardioprotection by implying that an early reinitiation of exercise after myocardial infarction attenuates left ventricular fibrosis and scar thinning, presumably by attenuating the coordinated proinflammatory response involving TNF-␣, IL-6, and IL-1␤. These findings could translate into clinical benefits in patients.CORONARY ARTERY DISEASE is the single most frequent cause of death worldwide. In Europe, every sixth man and every seventh woman will die of myocardial infarction (MI) (71). Those patients who survive MI frequently develop systolic heart failure due to the infarct-induced loss of functional myocardium per se and remodeling of the remainder of the left ventricular (LV) myocardium, which is frequently associated with thinning of the LV wall in the area of MI and its border zone, LV dilation, and systolic dysfunction. These parameters of myocardial remodeling are important prognostic markers for the long-term outcome of these patients. For instance, regional wall thinning is associated with postinfarction ventricular arrhythmia (36) and adverse outcome in patients undergoing coronary artery bypass surgery (87).Scar formation occurs secondary to isc...

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Section: H351 Exercise Limits Post-mi Scar Thinningsupporting

confidence: 90%

Exercise attenuates inflammation and limits scar thinning after myocardial infarction in mice

Puhl

Müller

Wagner

et al. 2015

American Journal of Physiology-Heart and Circulatory Physiology

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“…The results on the variable EF showed that different protocols of cardiac rehabilitation cause a significant increase in EF. The results of the research are consistent with the findings of studies conducted by Soleimannejad (11), Ghashghaei (10), Bahremand (34), Sadeghi (4), Basati (9), Schmid (14), and Kim (15). Ejection fraction shows the index of cardiac contractility that is obtained by dividing the stroke volume by the end-diastolic volume (EDV).…”

Section: Discussionsupporting

confidence: 89%

The Effect of Various Cardiac Rehabilitation Programs on Cardiac Dimensions of Post-CABG Patients

Saiiari

Kashef

Adel

et al. 2017

Jentashapir J Helath Res

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Background: In the majority of cardiovascular diseases, cardiovascular structure changes in line with the type of disease. One of the goals of cardiac rehabilitation is the improvement of cardiac performance and reversibility of hypertrophied cardiac dimensions. The present research aimed to compare the effectiveness of various cardiac rehabilitation programs on cardiac dimensions of patients with post-coronary artery bypass grafting (CABG). Methods: In this semi-experimental research, among CABG patients, 40 males with cardiovascular disease after CABG operation were selected using purposeful sampling method and divided into 4 groups of 10 persons: 1) aerobic continuous training group; 2) aerobic interval + resistance training group; 3) aerobic continuous + resistance training group; and 4) control group. Trainings were held for eight weeks, three training sessions a week, and every session included aerobic trainings with intensity of 50% -85% of reserved heart rate and resistance trainings with 40% -60% of maximum repetition. One day before and one day after the training intervention, the investigated variables were measured using two-dimensional echocardiography. For statistical analysis, the

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“…Simultaneously, medical administrators can continu- Table 1. Treatment models and characteristics of previous studies Treatment models Researchers Evaluation/monitoring methods Advantages and disadvantages Hospital-based CR Kim (Kim et al, 2011) LVEF It is applicable to a wide range of people; however, it is expensive and time consuming for patients, leading to low patient compliance.…”

Section: Introductionmentioning

confidence: 99%

Treatment models of cardiac rehabilitation in patients with coronary heart disease and related factors affecting patient compliance

2019

Reviews in Cardiovascular Medicine

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Coronary heart disease is a serious threat to human health. In China, medical care for the population has been focused on therapy with little follow-up of treated patients. The efficacy of therapy; however, is highly dependent on post-therapy recovery. Cardiac rehabilitation can significantly enhance patient physical strength and help delay and prevent the development of coronary atherosclerosis. Although the clinical significance of cardiac rehabilitation has been established, the compliance of patients is generally low. In efforts to improve patient compliance, domestic and foreign researchers have extensively studied and applied treatment models of cardiac rehabilitation according to the specific conditions and cultural background of each country. This study aimed to review the treatment models of cardiac rehabilitation in patients with coronary heart disease and related factors affecting patient compliance to provide a better perspective of how patients with coronary heart disease can benefit from cardiac rehabilitation.

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The Impact of Early Regular Cardiac Rehabilitation Program on Myocardial Function after Acute Myocardial Infarction

Cited by 20 publications

References 17 publications

Exercise attenuates inflammation and limits scar thinning after myocardial infarction in mice

Exercise attenuates inflammation and limits scar thinning after myocardial infarction in mice

The Effect of Various Cardiac Rehabilitation Programs on Cardiac Dimensions of Post-CABG Patients

Treatment models of cardiac rehabilitation in patients with coronary heart disease and related factors affecting patient compliance

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