The Impact of Diabetes on the Risk of Prostate Cancer Development according to Body Mass Index: A 10-year Nationwide Cohort Study

Choi, Jin Bong; Moon, Hyong Woo; Park, Young Hyun; Bae, Woong Jin; Cho, Hyuk Jin; Hong, Sung‐Hoo; Lee, Ji Youl; Kim, Sae Woong; Ha, U-Syn

doi:10.7150/jca.16110

Cited by 24 publications

(31 citation statements)

References 30 publications

(32 reference statements)

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“…It is reported that patients underweight or with normal weight may suffer from less beta-cell dysfunction and insulin resistance than those obese [ 14 ], while diabetic patients with higher BMI were more likely to experience insulin resistance due to adiposity [ 15 ]. T2DM and obesity were also observed to jointly promote the development of certain subtypes of cancer, but the results varied by cancer sites and across populations [ 16 – 18 ].…”

Section: Introductionmentioning

confidence: 99%

Body mass index and cancer risk among Chinese patients with type 2 diabetes mellitus

Zhang

Yan

et al. 2018

BMC Cancer

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BackgroundObesity and diabetes are two risk factors for cancer. To evaluate the association of body mass index (BMI) with cancer risk in diabetic patients may improve current understanding of potential mechanisms.MethodsA retrospective cohort study was conducted in 51,004 newly diagnosed T2DM patients derived from an electronic health record (EHR) database of Minhang district in Shanghai, China. Incident cancer cases and all-cause deaths occurred before September 30, 2015 were identified by linking with the Shanghai Cancer Registry and the Shanghai Vital Statistics. To examine the potential non-linear and linear relationships of BMI and cancer risk, Cox proportional hazard models with and without restricted cubic spline functions were used, respectively.ResultsA non-linear association was observed between BMI and overall cancer incidence in men younger than 60 years old (p for non-linearity = 0.009). Compared with those having BMI of 25.0 kg/m2, the cancer risk increased in those with either lower or higher BMI. In women older than 60 years old, linear dose-response relationships were observed between BMI and the risk of both overall cancer and breast cancer. As each unit increase in BMI, the overall cancer risks elevated by 3% (95%CI: 1–5%) and the breast cancer risks increased by 7% (95%CI: 1–13%). No significant association was observed between BMI and other common cancer sites.ConclusionsOur results show that the effect of BMI on cancer risk in Chinese patients with T2DM may vary by gender, age and cancer subtypes, suggesting different underlying biological mechanisms.Electronic supplementary materialThe online version of this article (10.1186/s12885-018-4675-0) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Body mass index and cancer risk among Chinese patients with type 2 diabetes mellitus

Zhang

Yan

et al. 2018

BMC Cancer

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“…Bladder cancer was coded C67. Because the Korean government enhanced benefit coverage for four major conditions (cardiovascular disease, cerebrovascular disease, cancer and rare diseases), all physician-diagnosed cancer patients are registered in the database 17 . Patient identification numbers were anonymized to protect individual privacy.…”

Section: Methodsmentioning

confidence: 99%

Estimating the impact of body mass index on bladder cancer risk: Stratification by smoking status

Choi

Han

Hong

et al. 2018

Sci Rep

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We estimated the impact of obesity on bladder cancer with stratification by smoking status using nationally representative data on the Korean population from the National Health Insurance System (NHIS). Of the 45,850,458 people who underwent at last one health examination from 2009 to 2012, 23,378,895 without bladder cancer were followed from the January 2009 to the December 2015. First, the HR for bladder cancer was lowest in people with a BMI < 18.5 (HR = 0.92) and highest for those with BMI ≥ 30 (HR = 1.17) in multiple Cox regression analyses. The positive association between bladder cancer and BMI showed an increasing trend beyond the reference BMI. Second, an analysis of HR for bladder cancer stratified by obesity across smoking status strata showed a significant trend of increasing HR for bladder cancer across obesity and smoking status in multivariate-adjusted models. Conclusively, this population-based study showed that increasing BMI was a risk factor for bladder cancer independent of confounding variables. When stratified by smoking status, there was still a positive association between bladder cancer and BMI (P for trend < 0.01).

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“…The cutoff value of WC for abdominal obesity of men was ≥90 cm [9]. Body mass index (BMI) categories, such as underweight (under 18.5), normal weight (18.5-22.9), overweight (23-24.9), and obese (over 25), were from the Korean Society for the Study of Obesity [10]. Finally, the definition of patients with metabolic diseases as used in this manuscript refers to individuals with at least one of the common components of metabolic syndrome (diabetes, hypertension, dyslipidemia).…”

Section: Methodsmentioning

confidence: 99%

Difference in prostate cancer incidence around sixty years: effects of age and metabolic diseases

et al. 2018

Self Cite

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We examined the risk of prostate cancer in the Korean population stratified on the basis of age group and risk based on metabolic diseases, using National Health Insurance System (NHIS) data. Of the 51,827,813 people from the NHIS data in 2015, 10,879,591 men without prostate cancer who underwent a health examination were analyzed. The risk of prostate cancer was analyzed with stratification by age. Multivariate‐adjusted Cox regression analysis was conducted to examine the association between prostate cancer and metabolic diseases by age groups. The risk of prostate cancer increased continuously with age and 59 years may be a point of inflection. The hazard ratio (HR) of prostate cancer development rose sharply as that age point passed. The population with metabolic diseases was more likely to develop prostate cancer than the population without any of these components. In addition, the incidence rate ratio (IRR) decreased from the youngest age group to the age group comprising 55–59 year olds. Beyond this age group, there was a plateau. The relative risk for prostate cancer associated with metabolic diseases also showed divergent associations with age. The risk of prostate cancer increased continuously with age and the peak Youden index was at 59 years. The relative risk for prostate cancer according to metabolic diseases also showed divergent associations beyond 59 years of age. Therefore, setting the age threshold at 59 years would improve the present clinical risk stratification for prostate cancer in Korea.

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The Impact of Diabetes on the Risk of Prostate Cancer Development according to Body Mass Index: A 10-year Nationwide Cohort Study

Cited by 24 publications

References 30 publications

Body mass index and cancer risk among Chinese patients with type 2 diabetes mellitus

Body mass index and cancer risk among Chinese patients with type 2 diabetes mellitus

Estimating the impact of body mass index on bladder cancer risk: Stratification by smoking status

Difference in prostate cancer incidence around sixty years: effects of age and metabolic diseases

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