The Impact of Copper in Children with Attention Deficit Hyperactivity Disorder

Tudosie, M; Truta, Elena; Daviţoiu, Ana Maria; Stanciulescu, Luminita; Jinescu, George; Mitu, Ana Mihaela; Forje, Margarita; Horhotă, Luminiţa; Bojescu, Alexandra Andrada; Mares, Alina Monica; Ionica, Mihai

doi:10.37358/rc.17.2.5436

Cited by 2 publications

(2 citation statements)

References 5 publications

(5 reference statements)

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“…The Tolerable Upper Intake Level (UL) of copper for adults is 10 mg/day, a value based on protection from liver damage as the critical adverse effect [16]. Thus, copper may be causing ADHD (attention deficit hyperactivity disorder) symptoms occur to children [18].…”

Section: Resultsmentioning

confidence: 99%

Nutritional and Food Safety Aspects Related to the Consumption of Edible Mushrooms from Dambovita County in Correlation with their Levels of Some Essential and Non-essential Metals

Georgescu¹,

Danet²,

Rădulescu³

et al. 2017

Rev. Chim.

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Ten edible mushroom species collected from four sites of Dambovita County, Romania, were analyzed through ICP-MS technique in order to evaluate their content in Fe, Cu, Zn, Pb and Cd, both in cap and stipe. Wild growing species (Russula vesca, Russula alutacea, Macrolepiota procera, Cantharellus cibarius, Boletus edulis, Agaricus campestris and Pleurotus ostreatus) and cultivated species (Pleurotus ostreatus, Agaricus bisporus white and Agaricus bisporus brown) were taken into account. The data related to the elemental composition of the fruiting bodies of mushrooms are important to be known having in view the nutritional and food safety related aspects. Higher concentrations of copper, iron and zinc have been found in Pleurotus ostreatus (cap), Macrolepiota procera (stipe) and Pleurotus ostreatus cultivated (cap) respectively, as follows: 43.90�0.96 mg/g d.w., 715.15�4.52 mg/g d.w. and 379.33�2.05 mg/g d.w. Although significant Health Risk Index were determined for lead in Agaricus campestris (about 0.1 both in cap and stipe) and for cadmium in Pleurotus ostreatus (0.58 in cap), these values are under the regulated PTWI limits for adult person.

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Section: Resultsmentioning

confidence: 99%

Nutritional and Food Safety Aspects Related to the Consumption of Edible Mushrooms from Dambovita County in Correlation with their Levels of Some Essential and Non-essential Metals

Georgescu¹,

Danet²,

Rădulescu³

et al. 2017

Rev. Chim.

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“…On the one hand, Cu is an essential element for the existence of life, important in several cellular mechanisms. Cu is part of the COX1 and COX2 subunits of the respiratory enzyme, cytochrome c oxidase, monoamine oxidase, SOD, tyrosinase, and ascorbic oxidase (41). Cu is an important antioxidant participating, along with Zn in the Cu-Zn SOD.…”

Section: Biological Role Of Cu In the Retina And Optic Nervementioning

confidence: 99%

Serum levels of copper and zinc in diabetic retinopathy: Potential new therapeutic targets (Review)

et al. 2022

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Diabetic retinopathy (DR) is a microvascular disorder occurring due to the long-term effects of diabetes, leading to vision-threatening damage to the retina. The human body has an elaborate system for managing and regulating the number of key trace metals circulating in the blood and stored cells. Inadequate zinc (Zn) and concurrent excess of copper (Cu) levels are associated with an increased level of oxidative stress, which may aggravate the microvascular lesions in diabetes mellitus. Several studies have revealed a significantly lower serum Zn concentration and increased Cu levels in DR when compared with diabetic patients without retinopathy and normal controls. These abnormalities are correlated with the duration of diabetes and higher levels of HbA1C. Multiple pathological mechanisms are proposed to explain these changes including hyperzincuria associated with polyuria, glycosuria, and proteinuria in diabetic patients, as well as impaired absorption of Zn at the gastrointestinal level. Increased levels of free Cu ions may be attributed to glycation and the release of Cu ions from the Cu-binding sites of proteins. Zn supplements and selective Cu chelators may be useful to alleviate oxidative stress and prevent DR progression.

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The Impact of Copper in Children with Attention Deficit Hyperactivity Disorder

Cited by 2 publications

References 5 publications

Nutritional and Food Safety Aspects Related to the Consumption of Edible Mushrooms from Dambovita County in Correlation with their Levels of Some Essential and Non-essential Metals

Nutritional and Food Safety Aspects Related to the Consumption of Edible Mushrooms from Dambovita County in Correlation with their Levels of Some Essential and Non-essential Metals

Serum levels of copper and zinc in diabetic retinopathy: Potential new therapeutic targets (Review)

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