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Cited by 234 publications
(280 citation statements)
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References 60 publications
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“…With an increase in the cross-sectional area of the device, there is increased inflammation in the week following implantation 29 (most likely due to increased parenchymal damage with insertion). 24,26 Furthermore, chronic inflammation in the 6 weeks following implantation is independent of device size, and it is believed that increasingly small devices will not circumvent inflammation in its entirety. 29 An endovascular approach may remedy this problem, as trauma to the brain parenchyma is not associated with electrode implantation.…”
Section: Brain-machine Interfacesmentioning
confidence: 99%
“…With an increase in the cross-sectional area of the device, there is increased inflammation in the week following implantation 29 (most likely due to increased parenchymal damage with insertion). 24,26 Furthermore, chronic inflammation in the 6 weeks following implantation is independent of device size, and it is believed that increasingly small devices will not circumvent inflammation in its entirety. 29 An endovascular approach may remedy this problem, as trauma to the brain parenchyma is not associated with electrode implantation.…”
Section: Brain-machine Interfacesmentioning
confidence: 99%
“…[7] Additionally, long-term breach of the highly-selective blood-brain barrier (BBB) eventually leads to secretion of neurotoxins that kill neurons proximal to the electrode, thereby diminishing the signal of interest permanently. [12] Contributing factors believed to adversely affect the quality of the electrode-tissue interface in a chronic time window include electrode size, [13,14] density of electrode material, [15] skull tethering mechanisms and associated micromotion of the implant, [16] and mechanical compliance of the electrode itself. [17,18] Considering the aforementioned characteristics, the ideal implantable electrode will be small, soft, mechanically-strong, and have a density similar to neural tissue.…”
Section: Introductionmentioning
confidence: 99%
“…Finally, recent work suggests that the disruption of blood-brain barrier (BBB) is yet another factor associated with the tissue response to the implanted devices [82]. The latter findings imply that the sharper devices such as Utah MEA or multitrode probes produce a greater BBB damage and yield more severe gliosis as compared to the metal electrode arrays consisting of relatively blunt cylindrical wires [95].…”
Section: Engineering Neural Probes For Optogenetic Experimentsmentioning
confidence: 91%