The Impact of Biofilms on Outcomes after Endoscopic Sinus Surgery

Singhal, Deepti; Psaltis, Alkis J.; Foreman, Andrew; Wormald, Peter‐John

doi:10.2500/ajra.2010.24.3462

Cited by 137 publications

(157 citation statements)

References 29 publications

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“…Many studies have indicated that biofilms play important roles in the pathogenesis of CRS and affect the outcomes of endoscopic sinus surgery [9][10][11][12][13][14].…”

Section: Discussionmentioning

confidence: 99%

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Clinical Characteristics of Biofilms in Patients with Chronic Rhinosinusitis: A Prospective Case–Control Study

Jung

Eog

Kang

et al. 2014

Indian J Otolaryngol Head Neck Surg

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Recent studies have indicated that biofilms are involved in the pathogenesis of recurrent and recalcitrant chronic rhinosinusitis (CRS). The present study was performed to evaluate the presence of biofilms and to evaluate the relationships between the presence of biofilms and clinical features of CRS. A total of 33 patients were included in this study. Maxillary sinus mucosa from 26 CRS patients and the ethmoid mucosa from 7 patients undergoing septoplasty were collected. Biofilms were evaluated by scanning electron microscopy. Preoperative symptom scores, preoperative and intraoperative nasoendoscopic findings, and postoperative healing period were compared between the groups. Biofilms were detected in 14 (42.4 %) of the 33 patients. Biofilms were present in 13 (50 %) of the 26 patients in the CRS group, but in only one (14.3 %) of the seven patients in the control group. There were no significant differences in preoperative symptom scores or preoperative nasal Lund-Kennedy endoscopic scores between the groups. However, the average LundMackay and intraoperative sinus Lund-Kennedy endoscopic scores were significantly higher in biofilm-positive than biofilm-negative patients (P \ 0.05). In the follow-up period, the healing time was significantly longer in biofilmpositive than biofilm-negative patients (P \ 0.05). This study suggested that the presence of bacterial biofilms may contribute to the pathogenesis of CRS and the clinical characteristics of CRS patients after endoscopic sinus surgery.

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“…Many studies have indicated that biofilms play important roles in the pathogenesis of CRS and affect the outcomes of endoscopic sinus surgery [9][10][11][12][13][14].…”

Section: Discussionmentioning

confidence: 99%

“…They also reported that bacterial biofilms affect prognosis [11,28]. Some authors reported poorer postoperative CT scores, postoperative symptoms, mucosal outcome, extra postoperative visits, and multiple antibiotic therapy in biofilmpositive patients [10,13].…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics of Biofilms in Patients with Chronic Rhinosinusitis: A Prospective Case–Control Study

Jung

Eog

Kang

et al. 2014

Indian J Otolaryngol Head Neck Surg

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“…The impact of this disease is often underappreciated, with sufferers having a significantly impaired quality of life. CRS remains a difficult condition to control medically, with a significant number of patients requiring endoscopic sinus surgery [11]. It is well established that biofilm-positive CRS patients are likely to have increased infective exacerbations and slower wound healing and mucosal restoration rates, in addition to a higher level of antibiotic dependence [11].…”

Section: Reactive Oxygen Species As a Novel Adjunctive Biofilm-targetmentioning

confidence: 99%

“…It is well established that biofilm-positive CRS patients are likely to have increased infective exacerbations and slower wound healing and mucosal restoration rates, in addition to a higher level of antibiotic dependence [11]. Staphylococcus aureus biofilms in particular have been identified as one of the main causative agents for chronicity and recalcitrance of the disease [11][12][13].…”

Section: Reactive Oxygen Species As a Novel Adjunctive Biofilm-targetmentioning

confidence: 99%

Reactive oxygen: A novel antimicrobial mechanism for targeting biofilm-associated infection

Dryden

Cooke

Salib

et al. 2017

Journal of Global Antimicrobial Resistance

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Reactive oxygen: a novel antimicrobial mechanism for targeting biofilm-associated infection, http://dx.doi.org/10. 1016/j.jgar.2016.12.006 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…333 Specifically, endpoints of postoperative symptoms, ongoing inflammation, and recurrent infections were all increased in biofilm-positive surgery patients. 323,[334][335][336][337] Biofilm formation in CRS may also be associated with increased need for surgical intervention. Although around 20% of patients with CRS show biofilm formation, 323 up to 50% of CRS surgical candidates are biofilm-positive.…”

Section: Viib Crssnp: Comorbid Asthmamentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

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554

888

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Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

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The Impact of Biofilms on Outcomes after Endoscopic Sinus Surgery

Abstract: This study has shown that patients with biofilms have more severe disease preoperatively and persistence of postoperative symptoms, ongoing mucosal inflammation, and infections. This study strengthens the evidence for the role that biofilms may play in recalcitrant CRS.

Cited by 137 publications

References 29 publications

Clinical Characteristics of Biofilms in Patients with Chronic Rhinosinusitis: A Prospective Case–Control Study

Clinical Characteristics of Biofilms in Patients with Chronic Rhinosinusitis: A Prospective Case–Control Study

Reactive oxygen: A novel antimicrobial mechanism for targeting biofilm-associated infection

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

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