The impact of age, sex, blepharitis, rosacea and rheumatoid arthritis on Demodex mite infection

Sędzikowska, Aleksandra; Osęka, Maciej; Skopiński, Piotr

doi:10.5114/aoms.2016.60663

Cited by 45 publications

(45 citation statements)

References 20 publications

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“…Regarding efficacy of antiparasitic effects, 100% D+ patients at baseline (16/50, 32%) turned negative after 16 weeks, proving the efficacy of ivermectin 1% cream in reducing Demodex density. In our study, according to the literature, the risk of Demodex infestation grows with age (average of D+ patient, 59 years old vs 54 years old in D– patients), but we did not find any significant differences (Lee, Chun, Kim, Kim, & Kim, ; Sędzikowska, Osęka, & Skopiński, ). Concerning the type of lesions, 87.5% of D+ patients presented a combination of erythema and papulopustules.…”

Section: Discussionsupporting

confidence: 55%

Real‐life experience on effectiveness and tolerability of topical ivermectin in papulopustular rosacea and antiparasitic effect on Demodex mites

Trave

Merlo

Cozzani

et al. 2019

Dermatologic Therapy

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Ivermectin is a drug approved for the treatment of papulopustular rosacea (PPR). Although clinical guidelines recommend the use of ivermectin as the first‐line treatment in patients with almost clear and mild rosacea, studies concerning its use on them are lacking. This study investigated the effectiveness and the tolerability of ivermectin in almost clear to severe rosacea and assessed the antiparasitic effect on Demodex mites. This is a retrospective study based on 50 patients affected by PPR and treated with topical ivermectin 1% once daily over 16 weeks. The disease severity, the patient‐examined improvement, and the safety assessment of patients were evaluated. Demodex mites were studied with the standardized skin surface biopsy. PPR to all severity achieved a therapeutic success. The number of inflammatory lesions was significantly decreased in almost clear (p < .0001), mild, moderate, and severe (p < .001) forms. A complete remission of inflammatory lesions was achieved by almost clear (p < .001) and mild (p = .005) with 82% with none‐to‐mild cutaneous adverse events. Thirty‐two percent were positive for Demodex mites, and all of them turned negative after 16 weeks. Ivermectin is an effective treatment not only in moderate to severe PPR but also in almost clear/mild rosacea.

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Section: Discussionsupporting

confidence: 55%

Real‐life experience on effectiveness and tolerability of topical ivermectin in papulopustular rosacea and antiparasitic effect on Demodex mites

Trave

Merlo

Cozzani

et al. 2019

Dermatologic Therapy

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“…In turn, Sedzikowska et al examined 134 patients with blepharitis and 76% had positive result for Demodex . The authors also found that the sex of the subjects was not a factor conducive to infection, but their age was positively correlated with the risk of infection [ 25 ]. In our study, the result was very similar, as 72% of the patients with blepharitis had positive result for the presence of Demodex but there was no significant relationship of the Demodex infestation with age and gender.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Ocular Demodicosis and Ocular Surface Conditions in Patients Selected for Cataract Surgery

Nowomiejska

Łukasik

Brzozowska

et al. 2020

JCM

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The aim of the study was to analyze the prevalence of ocular demodicosis and ocular surface conditions in patients selected for cataract surgery. Eyelashes from 73 patients selected for cataract surgery were evaluated at × 40 and × 100 magnification using light microscopy. The anterior segment was assessed with the slit lamp. Additionally, Schirmer I and break up time (BUT) tests were carried out before surgery and 1 and 3 months postoperatively. A specially designed questionnaire containing e.g. information about chronic skin and eye diseases, previous ophthalmic surgeries, and patient's hygiene habits was used to assess the demographic variables. A majority of patients were at the age of 70–79 years, and there were more females (83%) in the study group. Demodex folliculorum was found in 48% of the patients. There was a correlation between the number of parasites and the presence of blepharitis, discharge at eyelid margins, and conjunctival hyperemia. Schirmer I and BUT test results were lower in patients with Demodex infestation before and after cataract surgery. The higher number of mites was correlated with lower Schirmer I test results postoperatively. The presence of Demodex mites influences the conjunctiva and lid margins leading to inflammation. The higher number of Demodex mites disturbs the tear film over time after cataract surgery.

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“…Lower incidence of Demodex spp. infection was found by Sędzikowska et al [28] in patients of hospitals in Warsaw (47%). Wesołowska et al [22] determined the prevalence of infection of Demodex spp.…”

Section: Discussionmentioning

confidence: 88%

Concurrence of ocular infection with Demodex folliculorum

Kosik-Bogacka

Pyzia

Galant

et al. 2020

Preprint

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Background: The ectoparasite Demodex spp. is the most common human parasite detected in skin lesions such as rosacea, lichen, and keratosis. It is also an etiological factor in blepharitis. As Demodex spp. is involved in the transmission of pathogens that can play a key role in the pathogenesis of demodecosis, the aim was to assess the concurrence of Demodex folliculorum and bacterial infections.Methods: The study involved 232 patients, including 128 patients infected with Demodex folliculorum and 104 non-infected patients. The ophthalmological examination consisted of examining the vision of the patient with and without ocular correction, tonus in both eyes) and a careful examination of the anterior segment of both eyes with special emphasis on the appearance of the eyelid edges and the structure and appearance of eyelashes from both eyelids of both eyes. The samples for microbiological examination were obtained from the conjunctival sac. The bacterial culture was obtained by inoculating the samples on chocolate agar and agar with 5% sheep blood. After 24-48 h of incubation at 37 °C, the growth of various colonies of bacteria was identified based on morphological evaluation of the colonies on the media and preparations stained by the Gram method. Species identification was performed biochemical examination ex. coagulase test or VITEK Compact (bioMerieux, Poland).Results: Physiological flora was found in all patients infected with D. folliculorum and 9 (8.7%) participants from the control group.Only in patients infected with D. folliculorum we isolated Staphylococcus aureus (9 patients, 7%), Acinetobacter baumannii (one patient, 0.8%), Streptococcus pneumoniae (one patient, 0.8%), Klebsiella oxytoca (one patient, 0.8%), and Bacillus spp. (one patient, 0.8%) in the conjunctival sac.Conclusions: The occurrence of symptoms: dryness and burning sensation in the eye, tearing, conjuctival redness, foreign body sensation, eyelash loss, blockage of the Meibomian glands, cylindrical dandruff, and chalazia may suggest infection with Demodex spp. Patients infected with Demodex spp. should also undergo microbiological examination of conjunctival swabs. The treatment of each patient should be individualized, adapted to the clinical condition, and in cases of bacterial co-infection. Furthermore, daily hygiene of the eyelid margins should be recommended.

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The impact of age, sex, blepharitis, rosacea and rheumatoid arthritis on Demodex mite infection

Cited by 45 publications

References 20 publications

Real‐life experience on effectiveness and tolerability of topical ivermectin in papulopustular rosacea and antiparasitic effect on Demodex mites

Real‐life experience on effectiveness and tolerability of topical ivermectin in papulopustular rosacea and antiparasitic effect on Demodex mites

Prevalence of Ocular Demodicosis and Ocular Surface Conditions in Patients Selected for Cataract Surgery

Concurrence of ocular infection with Demodex folliculorum

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