The Impact of Advanced Glycation End-Products (AGEs) on Proliferation and Apoptosis of Primary Stem Cells: A Systematic Review

Evens, L; Beliën, Hanne; Deluyker, Dorien; Bronckaers, Annelies; Gervois, Pascal; Hendrikx, Marc; Bito, Virginie

doi:10.1155/2020/8886612

Cited by 13 publications

(12 citation statements)

References 90 publications

(151 reference statements)

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“…Even if they provide new insights into tissue regeneration, stem cells are transplanted in the border zone of MI with increased oxidative stress, inflammation, and AGEs' levels. Previous studies have shown that increased levels of AGEs affect stem cells' properties, i.e., by reducing their proliferation and migration properties [28]. Recently, we have demonstrated that the same adverse effects of AGEs apply to CASCs' properties in vitro [29].…”

Section: Combining Cascs and Pm To Enhance Cardiac Repairmentioning

confidence: 80%

“…These contribute to increased AGEs levels in patients suffering from MI. Recently, systematic review analysis [28] revealed that AGEs affect the viability and proliferation capacity of multiple types of stem cells in vitro, including CASCs [29], thereby affecting their therapeutic potential. These effects occur throughout several underlying mechanisms including excessive reactive oxygen species (ROS) generation, activation of the receptor for AGEs (RAGE), or via apoptotic pathways.…”

Section: Introductionmentioning

confidence: 99%

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Combinational Therapy of Cardiac Atrial Appendage Stem Cells and Pyridoxamine: The Road to Cardiac Repair?

Evens

Beliën

D'Haese

et al. 2021

IJMS

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Myocardial infarction (MI) occurs when the coronary blood supply is interrupted. As a consequence, cardiomyocytes are irreversibly damaged and lost. Unfortunately, current therapies for MI are unable to prevent progression towards heart failure. As the renewal rate of cardiomyocytes is minimal, the optimal treatment should achieve effective cardiac regeneration, possibly with stem cells transplantation. In that context, our research group identified the cardiac atrial appendage stem cells (CASCs) as a new cellular therapy. However, CASCs are transplanted into a hostile environment, with elevated levels of advanced glycation end products (AGEs), which may affect their regenerative potential. In this study, we hypothesize that pyridoxamine (PM), a vitamin B6 derivative, could further enhance the regenerative capacities of CASCs transplanted after MI by reducing AGEs’ formation. Methods and Results: MI was induced in rats by ligation of the left anterior descending artery. Animals were assigned to either no therapy (MI), CASCs transplantation (MI + CASCs), or CASCs transplantation supplemented with PM treatment (MI + CASCs + PM). Four weeks post-surgery, global cardiac function and infarct size were improved upon CASCs transplantation. Interstitial collagen deposition, evaluated on cryosections, was decreased in the MI animals transplanted with CASCs. Contractile properties of resident left ventricular cardiomyocytes were assessed by unloaded cell shortening. CASCs transplantation prevented cardiomyocyte shortening deterioration. Even if PM significantly reduced cardiac levels of AGEs, cardiac outcome was not further improved. Conclusion: Limiting AGEs’ formation with PM during an ischemic injury in vivo did not further enhance the improved cardiac phenotype obtained with CASCs transplantation. Whether AGEs play an important deleterious role in the setting of stem cell therapy after MI warrants further examination.

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Section: Combining Cascs and Pm To Enhance Cardiac Repairmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Combinational Therapy of Cardiac Atrial Appendage Stem Cells and Pyridoxamine: The Road to Cardiac Repair?

Evens

Beliën

D'Haese

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

“…It has been shown that SARS-CoV-2 activates mRAGE at pulmonary alveolar cells, leading to severe inflammatory reactions (Yalcin Kehribar et al, 2020). It has been confirmed that the concentration of sRAGE is reduced with aging, which might explain the susceptibility of old age to COVID-19 (Evens et al, 2020). However, in young and asymptomatic COVID-19 patients, the concentration of sRAGE is high.…”

Section: Testosterone and Acute Lung Injurymentioning

confidence: 97%

Testosterone in COVID-19: An Adversary Bane or Comrade Boon

Al-Kuraishy

Al-Gareeb

Faidah

et al. 2021

Front. Cell. Infect. Microbiol.

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COVID-19 is a pandemic disease caused by severe acute respiratory coronavirus 2 (SARS-CoV-2), which leads to pulmonary manifestations like acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). In addition, COVID-19 may cause extra-pulmonary manifestation such as testicular injury. Both high and low levels of testosterone could affect the severity of COVID-19. Herein, there is substantial controversy regarding the potential role of testosterone in SARS-CoV-2 infection and COVID-19 severity. Therefore, the present study aimed to review and elucidate the assorted view of preponderance regarding the beneficial and harmful effects of testosterone in COVID-19. A related literature search in PubMed, Scopus, Web of Science, Google Scholar, and Science Direct was done. All published articles related to the role of testosterone and COVID-19 were included in this mini-review. The beneficial effects of testosterone in COVID-19 are through inhibition of pro-inflammatory cytokines, augmentation of anti-inflammatory cytokines, modulation of the immune response, attenuation of oxidative stress, and endothelial dysfunction. However, its harmful effects in COVID-19 are due to augmentation of transmembrane protease serine 2 (TMPRSS2), which is essential for cleaving and activating SARS-CoV-2 spike protein during acute SARS-CoV-2 infection. Most published studies illustrated that low testosterone levels are linked to COVID-19 severity. A low testosterone level in COVID-19 is mainly due to testicular injury, the primary source of testosterone.

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“…But the stem cells also bring us a question: how to maximize their regenerative efficiency after transplantation? The fate of stem cells can be more dynamic than we expected including adhesion [ 4 ], migration [ 5 ], proliferation, and apoptosis [ 6 ]. Besides, the survival rate of stem cells after transplantation also remained unsatisfactory.…”

Section: Introductionmentioning

confidence: 99%

Metabolic Glycoengineering: A Promising Strategy to Remodel Microenvironments for Regenerative Therapy

Zhang

Tao

et al. 2023

Stem Cells International

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Cell-based regenerative therapy utilizes the differentiation potential of stem cells to rejuvenate tissues. But the dynamic fate of stem cells is calling for precise control to optimize their therapeutic efficiency. Stem cell fate is regulated by specific conditions called “microenvironments.” Among the various factors in the microenvironment, the cell-surface glycan acts as a mediator of cell-matrix and cell-cell interactions and manipulates the behavior of cells. Herein, metabolic glycoengineering (MGE) is an easy but powerful technology for remodeling the structure of glycan. By presenting unnatural glycans on the surface, MGE provides us an opportunity to reshape the microenvironment and evoke desired cellular responses. In this review, we firstly focused on the determining role of glycans on cellular activity; then, we introduced how MGE influences glycosylation and subsequently affects cell fate; at last, we outlined the application of MGE in regenerative therapy, especially in the musculoskeletal system, and the future direction of MGE is discussed.

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The Impact of Advanced Glycation End-Products (AGEs) on Proliferation and Apoptosis of Primary Stem Cells: A Systematic Review

Cited by 13 publications

References 90 publications

Combinational Therapy of Cardiac Atrial Appendage Stem Cells and Pyridoxamine: The Road to Cardiac Repair?

Combinational Therapy of Cardiac Atrial Appendage Stem Cells and Pyridoxamine: The Road to Cardiac Repair?

Testosterone in COVID-19: An Adversary Bane or Comrade Boon

Metabolic Glycoengineering: A Promising Strategy to Remodel Microenvironments for Regenerative Therapy

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