The impact and mechanism of quaternary ammonium compounds on the transmission of antibiotic resistance genes

Han, Ying‐Hao; Zhou, Zhen-Chao; Zhu, Lin; Wei, Yuanyuan; Feng, Wanqiu; Xu, Lan; Liu, Yang; Lin, Ze-Jun; Shuai, Xin-Yi; Zhang, Zhijian; Chen, Hong

doi:10.1007/s11356-019-05673-2

Cited by 91 publications

(55 citation statements)

References 54 publications

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“…The authors emphasize the need for further research into the importance of the presence of genes controlling resistance to antiseptics [ 63 ]. This need is confirmed in Han and co-workers’ research, in which they prove that QACs may facilitate the evolution and gene transfer of antibiotic resistance gene among microbiome [ 64 ].…”

Section: Current and Future Qas Application Trendsmentioning

confidence: 85%

Biological Activity of Quaternary Ammonium Salts and Their Derivatives

2020

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Besides their positive role, microorganisms are related to a number of undesirable effects, including many diseases, biodeterioration and food spoilage, so when their presence is undesired, they must be controlled. Numerous biocides limiting the development of microorganisms have been proposed, however, in this paper the biocidal and inhibitory activity of quaternary ammonium salts (QASs) and their zwitterionic derivatives is addressed. This paper presents the current state of knowledge about the biocidal activity of QAS and their derivatives. Moreover, the known mechanisms of antimicrobial activity and the problem of emerging resistance to QAS are discussed. The latest trends in the study of surfactants and their potential use are also presented.

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Section: Current and Future Qas Application Trendsmentioning

confidence: 85%

Biological Activity of Quaternary Ammonium Salts and Their Derivatives

2020

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“…The level of antimicrobial resistance was different than what was found in our study. Although antimicrobial resistance is largely attributed to indiscriminate use as growth promoters in farm animals [ 54 , 55 ] and the widespread use of quaternary ammonium disinfectants [ 56 ], nevertheless, the unreasonable use of antibiotics by pet owners, the limited surveillance and control of antimicrobial usage in companion animals, and the paucity of data on local antimicrobial resistance profiles and guidelines on rational antimicrobial usage in companion animals may have also contributed to the emergence of antimicrobial resistance [ 57 , 58 ]. The use of different methods for antimicrobial susceptibility testing and different breakpoints for the evaluation of the results in different countries may vary greatly, thus resulting in different levels of antimicrobial susceptibility according to the country [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

A Retrospective Study on Bacteriology, Clinicopathologic and Radiographic Features in 28 Cats Diagnosed with Pyothorax

Sim

Lau

Omar

et al. 2021

Animals

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This retrospective study aimed to determine the etiological, clinicopathological, and radiographic features and outcome of feline pyothorax cases. Medical records from twenty-eight cats with pyothorax aged from 4 months to 10 years (median 10 months) diagnosed between 2013 and 2020 were reviewed. Dyspnoea (75.0%), abnormal lung sounds (75.0%) and open-mouth breathing (64.3%) were the predominant respiratory signs. Leucocytosis (61.5%), particularly monocytosis (68.0%), and hyperglobulinaemia (65.4%) were among the most prominent findings in blood analysis. Bilateral pleural effusion was found in 67.9% of the thoracic radiographs. A total of 47.4% of the cytological samples revealed the presence of bacteria, while all had positive bacterial growth. Pasteurella multocida, E. coli, Streptococcus spp., and Staphylococcus spp. were the predominant aerobic bacteria isolated from pleural effusion samples. A chest tube was placed in 64.3% of the cats and 66.7% of cats with chest tubes survived. In total, 46.4% of cats with pyothorax recovered. Amoxicillin–clavulanate was the antimicrobial of choice against aerobic bacteria found in this study and should be given in combination with antimicrobials that cover anaerobic bacteria. Chest tube placement is crucial for treatment success. Cytological results and bacterial culture may not be consistent; thus, bacterial culture should be performed for every case.

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“…Globally, there has been widespread detection of ARGs (see Almakki et al, 2019; Han et al, 2019; Nnadozie & Odume, 2019; Vikesland et al, 2019). Therefore, not surprisingly, our research also found ARGs throughout the samples taken along the Volta River, indicating multiple sources of ARGs, possibly including aquaculture (river km 118, 82, and 67), urban development (Akuse, river km 92), small and poorly developed villages (Mepe, river km 52), agriculture (upstream of Sogakope, river km 32), and shellfish processing (Ada estuary, river km 1).…”

Section: Resultsmentioning

confidence: 99%

Contaminants of Emerging Concern in the Lower Volta River, Ghana, West Africa: The Agriculture, Aquaculture, and Urban Development Nexus

Chester

Gordon

Hartmann

et al. 2022

Enviro Toxic and Chemistry

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Contaminants of emerging concern (CECs) are ubiquitous in aquatic environments across all continents and are relatively well known in the developed world. However, few studies have investigated their presence and biological effects in low‐ and middle‐income countries. We provide a survey of CEC presence in the Volta River, Ghana, and examine the microbial consequences of anthropogenic activities along this economically and ecologically important African river. Water and sediment samples were taken by boat or from shore at 14 sites spanning 118 km of river course from the Volta estuary to the Akosombo dam. Sample extracts were prepared for targeted analysis of antimicrobial CECs, N,N‐diethyl‐meta‐toluamide, and per‐ and polyfluoroalkyl substances (PFAS; water only). Concurrent samples were extracted to characterize the microbial community and antibiotic‐resistant genes (ARGs). Antibiotics and PFAS (PFAS, 2–20 ng/L) were found in all water samples; however, their concentrations were usually in the low nanograms per liter range and lower than reported for other African, European, and North American studies. N,N‐Diethyl‐meta‐toluamide was present in all samples. The number of different genes detected (between one and 10) and total ARG concentrations varied in both water (9.1 × 10−6 to 8.2 × 10−3) and sediment (2.2 × 10−4 to 5.3 × 10−2), with increases in gene variety at sites linked to urban development, sand mining, agriculture, and shellfish processing. Total ARG concentration spikes in sediment samples were associated with agriculture. No correlations between water quality parameters, CEC presence, and/or ARGs were noted. The presence of CECs in the lower Volta River highlights their global reach. The overall low concentrations of CECs detected is encouraging and, coupled with mitigation measures, can stymie future CEC pollution in the Volta River. Environ Toxicol Chem 2022;41:369–381. © 2021 SETAC

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The impact and mechanism of quaternary ammonium compounds on the transmission of antibiotic resistance genes

Cited by 91 publications

References 54 publications

Biological Activity of Quaternary Ammonium Salts and Their Derivatives

Biological Activity of Quaternary Ammonium Salts and Their Derivatives

A Retrospective Study on Bacteriology, Clinicopathologic and Radiographic Features in 28 Cats Diagnosed with Pyothorax

Contaminants of Emerging Concern in the Lower Volta River, Ghana, West Africa: The Agriculture, Aquaculture, and Urban Development Nexus

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