Infectious Disease Clinics of North America volume 26, issue 3, P609-624 2012 DOI: 10.1016/j.idc.2012.06.003 View full text
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L.G. Visser

Abstract: This article reviews the normal immune response to vaccines. It describes the effect of different immunosuppressive therapies (glucocorticoids, inhibitors of calcineurin and mTOR, azathioprine, mycophenolate acid, methotrexate, depleting and nondepleting monoclonal antibodies, and tumor necrosis factor antagonists) on critical steps in the cellular and humoral immune responses to vaccines. The impact of age-related involution of thymus and bone marrow on the immune reconstitution in allogeneic hematopoietic ce…

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