The immediate haemodynamic response and right and left cardiac remodelling after percutaneous transcatheter closure of secundum atrial septal defect in children: a longitudinal cohort study

Abstract

Objective: We aimed to assess the immediate haemodynamic response and the timing of cardiac remodelling in paediatric secundum atrial septal defect patients who underwent percutaneous transcatheter closure. Methods: In this longitudinal cohort study with 41 paediatric secundum ASD patients who underwent PTC with Amplatzer Occluder device were assessed for immediate post-interventional haemodynamic response measured by catheterisation and was evaluated for right and left cardiac remodelling during a follow-up period of 12 months by transthoracic echocardiography. SPSS 20.0 was used for statistical analyses of pre- and post-interventional invasive haemodynamic parameters of the patients, and pre- and post-interventional TTE data compared with the values of the control group consisted of 39 healthy children. Results: The mean diameter of ASD was 13.9 ± 4.7 mm. PTC intervention in all patients completed with 100% success and 0% complication rates. All invasive haemodynamic data, except the ratio of pulmonary resistance to systemic resistance, significantly reduced after PTC (p < 0.05). TTE and PW Doppler revealed that right and left cardiac remodelling started as soon as the post-interventional 24th hour and completed in the 12th month. Conclusions: This study with a very high interventional success rate can be counted as the first example of research on the haemodynamic response and timing of cardiac remodelling after PTC of secundum ASD in children. We suggest that future multicentric studies with larger cohorts and a comprehensive methodology like ours with longer follow-up periods would better serve to further assess the cardiac remodelling in children after PTC of secundum ASD.

Temperate approach to ASD closure in pulmonary arterial hypertension: the fenestrated patch technique

“…However, since it allows patients to have a more comfortable early postoperative period with fewer complications, despite a theoretical increase in the risk of paradox embolism in the long term, it is often utilised in these surgeries. [16][17][18] In our series of patients, no paradoxical embolism or other complications developed in the early period. The NYHA class and symptoms of the patients were found to have decreased in the early period.…”

Facile synthesis of efficient Co3O4 nanostructures using the milky sap of Calotropis procera for oxygen evolution reactions and supercapacitor applications

“…Furthermore, the OER performance was evaluated, and the recently published results of the OER are given in Table 2. 78–97 It is obvious that the presented approach is facile, low cost, and efficient in terms of low overpotential, environmental friendliness and scale up for the fabrication of electrocatalyst materials.…”