1992
DOI: 10.1126/science.1542794
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Abstract: Leukemia inhibitory factor (LIF) and interleukin-6 (IL-6) are multifunctional cytokines with many similar activities. LIF is structurally and functionally related to another cytokine, Oncostatin M (OSM), that binds to the high-affinity LIF receptor but not to the low-affinity LIF receptor. A complementary DNA was isolated that encodes the high-affinity converting subunit of the LIF receptor. The converter conferred high-affinity binding of both LIF and OSM when expressed with the low-affinity LIF receptor and … Show more

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Cited by 863 publications
(433 citation statements)
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“…LIF belongs to the interleukin (IL)-6 family of cytokines, which also includes oncostatin M, ciliary neurotropic factor, IL-11, cardiotrophin, and IL-6 [9]. The IL-6-type cytokines all utilize the common gp130 receptor chain, and LIF signaling is mediated through the LIF receptor (LIFR-␤) which heterodimerizes with the gp130 receptor upon LIF binding [10]. Activation of the LIFR-␤-gp130 heterodimer results in the rapid activation of Janus kinases (JAKs) which in turn phosphorylate tyrosine residues of LIFR-␤ and gp130 [9,11].…”
Section: Introductionmentioning
confidence: 99%
“…LIF belongs to the interleukin (IL)-6 family of cytokines, which also includes oncostatin M, ciliary neurotropic factor, IL-11, cardiotrophin, and IL-6 [9]. The IL-6-type cytokines all utilize the common gp130 receptor chain, and LIF signaling is mediated through the LIF receptor (LIFR-␤) which heterodimerizes with the gp130 receptor upon LIF binding [10]. Activation of the LIFR-␤-gp130 heterodimer results in the rapid activation of Janus kinases (JAKs) which in turn phosphorylate tyrosine residues of LIFR-␤ and gp130 [9,11].…”
Section: Introductionmentioning
confidence: 99%
“…Human OSM utilizes two di erent types of receptor complexes. Both of them contain gp130 heterodimerized with either the LIFR (Gearing et al, 1992) or an OSM-speci®c receptor component (OSMRb) (Mosley et al, 1996). The structures of LIFR and OSMRb are closely related to gp130 and both molecules contribute to intracellular signaling.…”
Section: Introductionmentioning
confidence: 99%
“…Recent data suggests that these growth factors share a similar three dimensional structure (long chain a-helical bundle) and utilize cellular receptors that are all members of the structurally conserved hemopoietin receptor superfamily (Bazan, 1990;Gearing et al, 1989;Miyajima et al, 1992;Robinson et al, 1994). Their receptors all have a common receptor subunit (gp130) that is essential for biological signalling (Gearing et al, 1992;Kishimoto et al, 1992;Taga et al, 1989). For IL-6 and IL-11 it appears that intracellular signalling is mediated via a homodimer of gp130 while LIF, OSM and CNTF utilise the heterodimer between LIF and gp130.…”
Section: Introductionmentioning
confidence: 99%