Biochemical Pharmacology volume 80, issue 4, P455-462 2010 DOI: 10.1016/j.bcp.2010.05.011 View full text
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Marzia B. Gariboldi, Raffaella Ravizza, Elena Monti

Abstract: Inappropriate activation of the IGF (insulin-like growth factor) system has been implicated in the growth and progression of a number of tumor types. Recent evidence indicates a possible role for the IGF system in modulating/mediating tumor cell response to hypoxia, a common occurrence in solid tumors, and particularly in malignant gliomas, causing tumor cells either to die, or to mount a pleiotropic adaptive response that is mainly orchestrated through activation of the hypoxia-inducible transcription factor …

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