The idiopathic hypereosinophilic syndrome

Eosinophilic myocarditis in a patient with idiopathic hypereosinophilic syndrome: Insights into mechanisms of myocardial cell death

“…Finally, in the late stage, progressive scarring leads to endomyocardial fibrosis and restrictive cardiomyopathy. 1 In our patient, the results of the first biopsy showed widespread endomyocardial tissue damage caused by intense eosinophilic infiltration, with several areas of myocyte death. Histopathologic examination of the tissue sections stained with hematoxylin and eosin and PAS suggested that the myocyte death was attributable exclusively to a necrotic process, which was more marked within the granulomatous foci and the surrounding myocardium.…”

Eosinophil-derived IL-4 drives progression of myocarditis to inflammatory dilated cardiomyopathy

“…EAM in IL-5Tg mice is a model of eosinophilic myocarditis with hypereosinophilia. HES patients frequently develop endomyocardial thrombi, which are thought to result in endomyocarditis and endomyocardial fibrosis (Weller and Bubley, 1994;Ogbogu et al, 2007). We rarely observed intraatrial or intraventricular thrombi and observed no signs of endocarditis in IL-5Tg mice after EAM induction.…”

Unusual case of aortic valve involvement in patient with Löffler’s Endomyocarditis: management, follow-up and short review of the literature

“…Angiography may reveal apical obliteration and/or valvular insufficiency. Endomyocardial biopsies verify the diagnosis [3]. The patient in our case was diagnosed as IHES after the exclusion of the secondary causes of eosinophilia.…”