The identification of Meyerozyma guilliermondii from blood cultures and surveillance samples in a university hospital in Northeast Turkey: A ten-year survey

Güler, Nejla Cebeci; Tosun, İlknur; Aydın, Faruk

doi:10.1016/j.mycmed.2017.07.007

Cited by 17 publications

(9 citation statements)

References 36 publications

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“…reflect the progressive eutrophic and pollution status across the confluence stretch, since they are well known bio-indicators of pollution (Wang et al 2015). Furthermore, a higher relative abundance of uncommon opportunistic yeasts such as Kluveromyces, Lodderomyces, Clavispora, Meyerozyma, Yarrowia and Malassezia , previously isolated from bloodstream infections was also noted in this study (Lockhart et al 2008; Taj-Aldeen et al 2014; Cebeci Güler et al 2017). Besides, other opportunistic group of fungal pathogens such as Coccidioides, Paracoccidioides, Aspergillus, Penicillium responsible for respiratory tract infections and onchomycosis were also detected (Vélez and Díaz 2004; Montes et al 2015).…”

Section: Discussionsupporting

confidence: 77%

Fungal communities (Mycobiome) as potential ecological indicators within confluence stretch of Ganges and Yamuna Rivers, India

Samson

Rajput

Shah

et al. 2019

Preprint

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38River confluences are a hub of biodiversity with limited information with respect to the structure and the 39 functions of the microbial communities. The 'River Ganges' is the national river of India, having manifold 40 significance such as social, mythological, historic, geographic and agro-economic. It forms a sacred confluence 41 (known as Triveni Sangam) with River Yamuna at Prayagraj, India. Recent reports indicated the presence of fecal 42 coliform bacteria, an indicator recognized for water contamination in Ganges River leading to pollution. However, 43Fungi are also gaining attention as potential biological indicators of the trophic status of some rivers globally, but 44 remain under-explored in terms of diversity, ecology and functional aspects. We performed whole long read, 45 metagenome sequencing (MinION) of the sediment samples collected in December 2017 from confluence zone of 46 Ganges and Yamuna Rivers spanning the pre-confluence, confluence and post-confluence zones. Mycobiome reads 47 revealed a plethora of fungal communities, extending from saprophytes, endoparasites and edible fungi, to human 48 pathogens, plant pathogens and toxin producers. The fungal genera recognized as bio-indicators of river pollution 49 (Aspergillus, Penicillium) and eutrophication (Kluveromyces, Lodderomyces, and Nakaseomyces), were present in 50 all samples. Functional gene analyses of myco-communities uncovered hits for neurodegenerative diseases and 51 xenobiotic degradation potential, supporting bio-indicators of pollution. This study forms a foundational basis for 52 understanding the impact of various anthropogenic activities on the mycobiome, as a bio-indicator of pollution 53 across the confluence of Ganges and Yamuna Rivers and post-confluence of River Ganges, and could be useful in 54 mitigating strategies for cleaning strategies of the Ganges River.55

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Section: Discussionsupporting

confidence: 77%

Fungal communities (Mycobiome) as potential ecological indicators within confluence stretch of Ganges and Yamuna Rivers, India

Samson

Rajput

Shah

et al. 2019

Preprint

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“…Approximately 5.5% of all Candida isolates were uncommon species, such as C. nivariensis , C. guilliermondii , and C. caribbica . These rare yeasts have been reported as emerging causes of BSI [ 19 , 20 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

Species Distribution, Antifungal Susceptibility, and Molecular Epidemiology of Candida Species Causing Candidemia in a Tertiary Care Hospital in Bangkok, Thailand

Boonsilp

Homkaew

Phumisantiphong

et al. 2021

JoF

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Candida species represent a common cause of bloodstream infection (BSI). Given the emergence of non-albicans Candida (NAC) associated with treatment failure, investigations into the species distribution, fungal susceptibility profile, and molecular epidemiology of pathogens are necessary to optimize the treatment of candidemia and explore the transmission of drug resistance for control management. This study evaluated the prevalence, antifungal susceptibility, and molecular characteristics of Candida species causing BSI in a tertiary-level hospital in Bangkok, Thailand. In total, 54 Candida isolates were recovered from 49 patients with candidemia. C. tropicalis was the most prevalent species (33.3%), followed by C. albicans (29.6%). Most Candida species were susceptible to various antifungal agents, excluding C. glabrata and C. tropicalis, which had increased rates of non-susceptibility to azoles. Most C. glabrata isolates were non-susceptible to echinocandins, especially caspofungin. The population structure of C. albicans was highly diverse, with clade 17 predominance. GoeBURST analysis of C. tropicalis revealed associations between genotype and fluconazole resistance in a particular clonal complex. The population structure of C. glabrata appeared to have a low level of genetic diversity in MLST loci. Collectively, these data might provide a fundamental database contributing to the development of novel antifungal agents and diagnostic tests.

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“…Candida guilliermondii has been isolated from numerous human infections, mostly of cutaneous origin, but it is also found on normal skin, in sea water, animal faeces, wasps, buttermilk, leather, fish, and beer [8]. The species Meyerozyma guilliermondii is most often associated with onychomycosis and candidemia [9].…”

Section: Introductionmentioning

confidence: 99%

Allium sativum Extract Chemical Composition, Antioxidant Activity and Antifungal Effect against Meyerozyma guilliermondii and Rhodotorula mucilaginosa Causing Onychomycosis

et al. 2019

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Onychomycosis is a major health problem due to its chronicity and resistance to therapy. Because some cases associate paronychia, any therapy must target the fungus and the inflammation. Medicinal plants represent an alternative for onychomycosis control. In the present work the antifungal and antioxidant activities of Alium sativum extract against Meyerozyma guilliermondii (Wick.) Kurtzman & M. Suzuki and Rhodotorula mucilaginosa (A. Jörg.) F.C. Harrison, isolated for the first time from a toenail onychomycosis case, were investigated. The fungal species were confirmed by DNA molecular analysis. A. sativum minimum inhibitory concentration (MIC) and ultrastructural effects were examined. At the MIC concentration (120 mg/mL) the micrographs indicated severe structural alterations with cell death. The antioxidant properties of the A. sativum extract were evaluated is a rat turpentine oil induced inflammation, and compared to an anti-inflammatory drug, diclofenac, and the main compound from the extract, allicin. A. sativum reduced serum total oxidative status, malondialdehyde and nitric oxide production, and increased total thiols. The effects were comparable to those of allicin and diclofenac. In conclusion, the garlic extract had antifungal effects against M. guilliermondii and R. mucilaginosa, and antioxidant effect in turpentine-induced inflammation. Together, the antifungal and antioxidant activities support that A. sativum is a potential alternative treatment in onychomycosis.

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The identification of Meyerozyma guilliermondii from blood cultures and surveillance samples in a university hospital in Northeast Turkey: A ten-year survey

Cited by 17 publications

References 36 publications

Fungal communities (Mycobiome) as potential ecological indicators within confluence stretch of Ganges and Yamuna Rivers, India

Fungal communities (Mycobiome) as potential ecological indicators within confluence stretch of Ganges and Yamuna Rivers, India

Species Distribution, Antifungal Susceptibility, and Molecular Epidemiology of Candida Species Causing Candidemia in a Tertiary Care Hospital in Bangkok, Thailand

Allium sativum Extract Chemical Composition, Antioxidant Activity and Antifungal Effect against Meyerozyma guilliermondii and Rhodotorula mucilaginosa Causing Onychomycosis

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