2017
DOI: 10.18632/aging.101196
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Abstract: TP53, a tumor suppressor gene, plays a critical role in cell cycle control, apoptosis, and DNA damage repair. Previous studies have indicated that the TP53 gene Arg72Pro (rs1042522 C>G) polymorphism is associated with susceptibility to various types of cancer. We evaluated the association of the TP53 gene rs1042522 C>G polymorphism with neuroblastoma susceptibility in a hospital-based study among the Chinese Han population. Enrolled were 256 patients and 531 controls. Odds ratios (ORs) and 95% confidence inter… Show more

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Cited by 56 publications
(48 citation statements)
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References 51 publications
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“…Allele‐specific probes were purchased from Applied Biosystems (Applied Biosystems, Foster City, CA, USA). The polymerase chain reaction (PCR) was performed in 384‐well plates in an ABI‐Q6 real‐time PCR system . Moreover, to ensure the quality and accuracy of the genotyping results, we randomly selected 10% of the samples for repeat analysis, and the results were found to be 100% concordant.…”
Section: Methodsmentioning
confidence: 99%
“…Allele‐specific probes were purchased from Applied Biosystems (Applied Biosystems, Foster City, CA, USA). The polymerase chain reaction (PCR) was performed in 384‐well plates in an ABI‐Q6 real‐time PCR system . Moreover, to ensure the quality and accuracy of the genotyping results, we randomly selected 10% of the samples for repeat analysis, and the results were found to be 100% concordant.…”
Section: Methodsmentioning
confidence: 99%
“…Specimens were annotated with information including age at diagnosis, sex, and disease stage based on the NWTS-5 criteria. The 531 cancer-free controls were selected from children visiting the same hospital for a regular physical examination during the same period of time 36, 37, 38, 39. Frequency matching was performed for cases and controls on age and sex.…”
Section: Methodsmentioning
confidence: 99%
“…In brief, we identified 275 histologically confirmed neuroblastoma cases among Guangdong residents from the Guangzhou Women and Children's Medical Center between February 2010 and March 2017. During the same period, 531 age‐matched, sex‐matched, and ethnicity‐matched control subjects also were collected from the same hospital . Before their participation, we obtained written informed consent for all the included subjects.…”
Section: Methodsmentioning
confidence: 99%
“…During the same period, 531 age-matched, sex-matched, and ethnicity-matched control subjects also were collected from the same hospital. 47,48 Before their participation, we obtained written informed consent for all the included subjects. This study was approved by the institutional review boards of both hospitals.…”
Section: Study Subjectsmentioning
confidence: 99%