The HYPERcollar: A novel applicator for hyperthermia in the head and neck

Paulides, Margarethus M.; Bakker, Jurriaan F.; Neufeld, Esra; Zee, Jacoba van der; Jansen, Peter P.; Levendag, P.; Rhoon, Gerard C. van

doi:10.1080/02656730701670478

Cited by 117 publications

(86 citation statements)

References 18 publications

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“…In mentioned article [6] the circular system on a numerical 3D human model was tested. The analysis was performed numerically (using 3D model with lymphonode and small tumor) and also by measurement.…”

Section: Resultsmentioning

confidence: 99%

“…As we know, some circular phase array systems intended for head and neck hyperthermia treatment are currently under development (e.g. Paulides et al (2007) [6] and Trefna et al (2010) [14]). …”

Section: Introductionmentioning

confidence: 99%

“…Curability depends on used frequency and depth of the tumor under the skin [3]. The clinical trials (phase III) show that a combination of hyperthermia treatment, radiotherapy [4] and chemotherapy [5] improves the survival chance of patients with head and neck tumors [6,7] and [8]. Microwave hyperthermia belongs to nontoxic oncological treatment using frequencies 60-120, 434 and 915 MHz [3,9] and [10].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Waveguide Applicator System for Head and Neck Hyperthermia Treatment

Fišer¹,

Merunka²,

Vrba³

2016

Journal of Electrical Engineering and Technology

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-The main purpose of this article is a complex hyperthermia applicator system design for treatment of head and neck region. The applicator system is composed of four waveguides with a stripline horn aperture and circular water bolus. The specific absorption rate (SAR) and temperature distribution from this applicator in various numerical phantom models was investigated. For used targets, the treatment planning based on the optimization process made through the SEMCAD X software is added to show the steering possibilities of SAR and thereby temperature distribution. Using treatment planning software, we proved that the SAR and temperature distribution can be effectively controlled (by amplitude and phase changing) improving the SAR and temperature target coverage approximately by 20 %. For the proposed applicator system analysis and quantitative evaluation of two parameters 25 % iso-SAR and 41°C iso-temperature contours in the treatment area with the respect to sensitive structures in treatment area were defined. To verify our simulation results, the real measurement of reflectivity coefficient as well as the temperature distribution in a homogenous phantom were performed.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Waveguide Applicator System for Head and Neck Hyperthermia Treatment

Fišer¹,

Merunka²,

Vrba³

2016

Journal of Electrical Engineering and Technology

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“…The platform has also been used to develop a novel head and neck applicator [10,11] and to assess the safety of hyperthermia in the presence of metallic implants. It was validated on the basis of dosimetric measurements and clinical information.…”

Section: Rsfsroyalsocietypublishingorg Interface Focus 3: 20120058mentioning

confidence: 99%

A novel medical image data-based multi-physics simulation platform for computational life sciences

et al. 2013

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One contribution of 25 to a Theme Issue 'The virtual physiological human: integrative approaches to computational biomedicine'. Simulating and modelling complex biological systems in computational life sciences requires specialized software tools that can perform medical image data-based modelling, jointly visualize the data and computational results, and handle large, complex, realistic and often noisy anatomical models. The required novel solvers must provide the power to model the physics, biology and physiology of living tissue within the full complexity of the human anatomy (e.g. neuronal activity, perfusion and ultrasound propagation). A multi-physics simulation platform satisfying these requirements has been developed for applications including device development and optimization, safety assessment, basic research, and treatment planning. This simulation platform consists of detailed, parametrized anatomical models, a segmentation and meshing tool, a wide range of solvers and optimizers, a framework for the rapid development of specialized and parallelized finite element method solvers, a visualization toolkit-based visualization engine, a PYTHON scripting interface for customized applications, a coupling framework, and more. Core components are cross-platform compatible and use open formats. Several examples of applications are presented: hyperthermia cancer treatment planning, tumour growth modelling, evaluating the magneto-haemodynamic effect as a biomarker and physics-based morphing of anatomical models.

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“…In Rotterdam in 2003 we started developing techniques for external heating in the H&N region, including the nasopharynx [14,15]. Treatments performed thus far have shown the feasibility of deep heating by a non-invasive technique using microwaves [16].…”

mentioning

confidence: 99%