The human neutrophil. Function and dysfunction

Borregaard, Niels

doi:10.1111/j.1600-0609.1988.tb00219.x

Cited by 107 publications

(27 citation statements)

References 115 publications

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“…In response to different stimuli, activated neutrophils secrete a series of cytotoxins, such as superoxide anion (O ÅÀ 2 ), a precursor of other reactive oxygen species (ROS), granule proteases, and bioactive lipids (Borregaard, 1998;Roos, van Bruggen, & Meischl, 2003;Witko-Sarsat et al, 2000). Suppression of the extensive or inappropriate activation of neutrophils by drugs has been proposed as a way to ameliorate inflammatory diseases.…”

Section: Biological Studiesmentioning

confidence: 99%

A new phragmalin-type limonoid and anti-inflammatory constituents from the fruits of Swietenia macrophylla

et al. 2010

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Section: Biological Studiesmentioning

confidence: 99%

A new phragmalin-type limonoid and anti-inflammatory constituents from the fruits of Swietenia macrophylla

et al. 2010

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“…Neutrophil function has been examined by measuring neutrophil elastase (PMN-elastase). Neutrophil elastase is one of the major enzymes in neutrophils and is upregulated during activation [25] . During surgical procedures there is a massive release from the neutrophils of elastase [25,26] , along with other proteinases.…”

Section: Discussionmentioning

confidence: 99%

“…Neutrophil elastase is one of the major enzymes in neutrophils and is upregulated during activation [25] . During surgical procedures there is a massive release from the neutrophils of elastase [25,26] , along with other proteinases. Therefore, the measurement of the elastase-α1-protease inhibitor complex might be a and post-operative values were significant in both groups (using the Friedman test, a P < 0.05).…”

Section: Discussionmentioning

confidence: 99%

Systemic inflammation and immune response after laparotomyvslaparoscopy in patients with acute cholecystitis, complicated by peritonitis

Sista

Schietroma²,

Santis³

et al. 2013

WJGS

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AIM:To evaluate acute cholecystitis, complicated by peritonitis, acute phase response and immunological status in patients treated by laparoscopic or open approach. METHODS:From January 2002 to May 2012, we conducted a prospective randomized study on 45 consecutive patients (27 women, 18 men; mean age 58 years). These subjects were taken from a total of 681 patients who were hospitalised presenting similar preoperative findings: acute upper abdominal pain with tenderness, involuntary guarding under the right hypochondrium and/or in the flank; fever higher than 38 ℃, leukocytosis greater than 10 × 10 9 /L or both, and ultrasonographic evidence of calculous cholecystitis possibly complicated by peritonitis. These patients had undergone cholecystectomy for acute calculous cholecystitis, complicated by bile peritonitis. Randomly, 23 patients were assigned to laparoscopic cholecystectomy (LC), and 22 patients to open cholecystectomy (OC). Blood samples were collected from all patients before operation and at days 1, 3 and 6 after surgery. Serum bacteraemia, endotoxaemia, white blood cells (WBCs), WBC subpopulations, human leukocyte antigen-DR (HLA-DR), neutrophil elastase, interleukin-1 (IL-1) and IL-6, and C-reactive protein (CRP) were measured at 0, 30, 60, 90, 120 and 180 min, at 4, 6, 12, 24 h, and then daily (8 A.M.) until post-operative day 6. RESULTS:The two groups were comparable in the severity of peritoneal contamination as indicated by the viable bacterial count (open group = 90% of positive cultures vs laparoscopic group = 87%) and endotoxin level (open group = 33.21 ± 6.32 pg/mL vs laparoscopic group = 35.02 ± 7.23 pg/mL). Four subjects in the OC group (18.1%) and 1 subject (4.3%) in the LC group (P < 0.05) developed intra-abdominal abscess. Severe leukocytosis (range 15.8-19.6/mL) was observed only after OC but not after LC, mostly due to an increase in neutrophils (days 1 and 3, P < 0.05). This value returned to the normal range within 3-4 d after LC and 5-7 d after OC. Other WBC types and lymphocyte subpopulations showed no significant variation. On the first day after surgery, a statistically significant difference was observed in HLA-DR expression between LC (13.0 ± 5.2) and OC (6.0 ± 4.2) (P < 0.05). A statistically significant change in plasma elastase concentration was recorded post-operatively at days 1, 3, and 6 in patients from the OC group when compared to the LC group (P < 0.05). In the OC group, the serum levels of IL-1 and IL-6 began to increase considerably from the first to the sixth hour after surgery. In the LC group, the increase of serum IL-1 and IL-6 levels was delayed and the peak values were notably lower than those in the OC group. Significant differences between the groups, for these two cytokines, were observed from the second to the twenty-fourth hour (P < 0.05) after surgery. The mean values of serum CRP in the LC group on post-operative days (1 and 3) were also lower than those in the OC group (P < 0.05). Systemic concentration of endotoxin was higher in the OC grou...

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“…In response to different stimuli, activated neutrophils secrete a series of cytotoxins, such as the superoxide anion radical (O ÅÀ 2 ), a precursor of other reactive oxygen species (ROS), granule proteases, bioactive lipids, and neutrophil elastase, a major contributor to destruction of tissue in chronic inflammatory disease (Borregaard, 1998;Roos, van Bruggen, & Meischl, 2003;Witko-Sarsat, Rieu, Descamps-Latscha, Lesavre, & Halbwachs-Mecarelli, 2000). Suppression of the extensive or inappropriate activation of neutrophils by drugs has been proposed as a way to ameliorate inflammatory diseases.…”

Section: Biological Studiesmentioning

confidence: 97%