volume 66, issue 7, P4452-4456 1992
DOI: 10.1128/jvi.66.7.4452-4456.1992
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Abstract: We have asked how the human cytomegalovirus major immediate-early 1 (TEl) and 2 (IE2) proteins act to transactivate heterologous cellular and viral promoters. Here we show that transactivation of the human immunodeficiency virus long terminal repeat and the 70,000-molecular-weight heat shock protein (hsp70) promoter by TEl is TATA box independent and that the IE1 protein does not interact directly with the TATA box-binding factor TFIID. Conversely, transactivation of these promoters by IE2 is TATA box dependen…

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