The Human Bocaviruses: A Review and Discussion of Their Role in Infection

Chow, Brian; Esper, Frank

doi:10.1016/j.cll.2009.07.010

Cited by 59 publications

(73 citation statements)

References 107 publications

(155 reference statements)

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“…Our results was in agreement with Jiang et al, (2016) who reported that the infections almost completely confine to infants and young children also in agreement with most of the previous studies by Allender et al, (2005), Choi et al, (2006), Chow et al, (2009) and Abdel-Moneim et al, (2013). However, some authors reported that HBoV is also a frequent virus in adults with respiratory disease Guido et al, (2012) and Ghietto et al, (2012).…”

Section: Resultssupporting

confidence: 82%

Detection of Human Bocavirus in Egyptian Children Suffering from Acute Lower Respiratory Tract Infection

Atef¹,

Elbehedy²

2017

Int.J.Curr.Microbiol.App.Sci

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Section: Resultssupporting

confidence: 82%

Detection of Human Bocavirus in Egyptian Children Suffering from Acute Lower Respiratory Tract Infection

Atef¹,

Elbehedy²

2017

Int.J.Curr.Microbiol.App.Sci

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“…HBoV-1 was commonly co-detected with a median rate of 42.5 %, and the most frequent co-detected viruses included rhinovirus, enteroviruses, and influenza [23]. We demonstrated a co-detection rate of 77.72 %, which is similar to the high proportion of co-detection as previously studied [24], yet significantly higher than those from other studies [9,12].…”

Section: Discussionsupporting

confidence: 85%

Epidemic and molecular evolution of human bocavirus in hospitalized children with acute respiratory tract infection

Wang

et al. 2014

Eur J Clin Microbiol Infect Dis

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Human bocavirus (HBoV) is a novel parvovirus, often associated with respiratory tract diseases in children. This study explored the epidemiological characteristics and molecular evolution of HBoV-1 in southeastern China. Nasopharyngeal aspirates were collected from children admitted to hospital with acute respiratory tract infections. HBoV-1 was detected using real-time reverse transcription polymerase chain reaction and further characterized by complete genome sequences analysis. Among the 3,022 recruited children, 386 (12.77%) were HBoV-1-positive and 300 (77.72%) had co-detection with other respiratory viruses. Seasonal prevalence peaked in summer. HBoV-1 presence was significantly associated with asthma attack [odds ratio = 1.74; 95 % confidence interval: 1.30, 2.31; p < 0.001]. Similar results were obtained when either single detection or co-detection of HBoV-1 was considered, demonstrating the minor impact of co-detection on the clinical characteristics or epidemic pattern. Phylogenetic analysis based on the complete genome sequences showed that all the HBoV-1 sequences clustered together and no branch was formed that was supported by bootstrap value ≥ 750. The overall evolutionary rate of the complete genome of HBoV-1 was estimated at 1.08 × 10(-4) nucleotide substitutions per site per year (s/s/y) [95% highest probability density: (0.40-1.86) × 10(-4) s/s/y]. Selective pressure analysis showed that all the ω-values were less than 1, suggesting that HBoV-1 was under negative selective pressure. Site-by-site analysis identified the codon site 40 of the VP1 gene under positive selection. In conclusion, our study disclosed the epidemiological and genetic dynamics of HBoV-1 epidemics in southeastern China in the most recent 3 years, the information of which might help to further improve our understanding of HBoV-1 infection and guide better surveillance and control strategies in the future.

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“…Many studies have been published investigating the role of the virus in respiratory tract illness (6). Some raise the possibility that HBoV is associated with severe respiratory disease (7,8).…”

Section: Case Reportmentioning

confidence: 99%