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“…Other basophil growth regulators include granulocyte/macrophage colony‐stimulating factor (GM‐CSF), IL‐5, transforming growth factor‐beta (TGF‐ß) and thymic stromal lymphopoietin (TSLP) 33, 34, 35. In mature basophils, additional factors and molecules, such as complement factors (C3a, C5a) are involved in the regulation of survival, migration, adhesion and activation 36. Most of these cytokines are considered to act on CML basophils in the same way as on normal basophils 27, 32, 36…”
Section: Basophil Differentiation In Healthy Bm and In Ph+ CMLmentioning
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“…Other basophil growth regulators include granulocyte/macrophage colony‐stimulating factor (GM‐CSF), IL‐5, transforming growth factor‐beta (TGF‐ß) and thymic stromal lymphopoietin (TSLP) 33, 34, 35. In mature basophils, additional factors and molecules, such as complement factors (C3a, C5a) are involved in the regulation of survival, migration, adhesion and activation 36. Most of these cytokines are considered to act on CML basophils in the same way as on normal basophils 27, 32, 36…”
Section: Basophil Differentiation In Healthy Bm and In Ph+ CMLmentioning
“…Cross-linking of Fc⑀RI on basophils by an allergen or by other compounds is followed by rapid release of mediators and cytokines into the extracellular space with consecutive edema formation and tissue inflammation that may lead to the clinical picture of an anaphylactic reaction. [1][2][3][4][5][6] Activation of the Fc⑀RI is associated with activation of several signal transduction pathways. [3][4][5][6][7][8][9] Tyrosine phosphorylation of several kinases is an early event in Fc⑀RI-dependent signaling.…”
Section: Introductionmentioning
“…[1][2][3][4] These cells express the high-affinity receptor for immunoglobulin E (IgE), Fc⑀RI, and synthesize numerous proinflammatory and vasoactive mediators such as histamine, leukotrienes, and cytokines. [2][3][4][5][6] Most of these mediators including histamine, are stored within the metachromatic granules of basophils. Cross-linking of Fc⑀RI on basophils by an allergen or by other compounds is followed by rapid release of mediators and cytokines into the extracellular space with consecutive edema formation and tissue inflammation that may lead to the clinical picture of an anaphylactic reaction.…”
Section: Introductionmentioning
“…Basophils and mast cells are important effector cells of inflammatory reactions [1][2][3]. In contrast to eosinophils and neutrophils, they possess high-affinity immunoglobulin (Ig) E receptors (FcεRI) that are cross-linked upon engagement of receptor-bound IgE with allergens, resulting in the release of several mediators to the extracellular space or in the transport of vesicle-bound membrane proteins to the plasma membrane [4][5].…”
Section: Introductionmentioning