The hOGG1 Ser326Cys Polymorphism Is Not Associated with Colorectal Cancer Risk

Common Polymorphisms in the XPD and hOGG1 Genes Are Not Associated with the Risk of Colorectal Cancer in a Polish Population

“…Therefore, study performed in different populations should be compared to justify this thesis. Our results indicating a lack of association are in agreement to those performed in a Korean population, despite distinct ethnic differences (Park et al 2007). It is worth noting that the frequency of the Ser326Cys genotype in the controls in that study was 0.49, almost 2-fold higher than that reported by us.…”

Assessing Tumor Mutations to Gain Insight into Base Excision Repair Sequence Polymorphisms and Smoking in Colon Cancer

“…Park et al reported that the S326C polymorphism was not associated with tumor location or MSI status in colorectal cancer patients (6), and Sliwiski et al did not find a correlation between this variant and colorectal cancer occurrence or progression (27). In a study of 125 cases and 247 matched controls, Kim et al previously reported the homozygous variant S326C genotype was associated with colon cancer in smokers (5).…”

“…As the colon may be subject to exposure to oxygen free radicals, reduced activity of OGG1 may be a risk factor in colon carcinogenesis. However a limited number of studies of S326C and colon cancer have been conducted (5, 6). Another protein, XRCC1, is critical in the BER pathway, interacting with several BER enzymes to modify and stabilize their activity (2).…”

The hOGG1 gene 5′-UTR variant c.−53G>C contributes to the risk of gastric cancer but not colorectal cancer in the Chinese population

“…Several studies have suggested that the Cys326 allele could be associated with the increased risk for prostate, lung, esophageal, and a subset of gastric cancers (Pawlowska et al 2009). However, Kim et al (2003) and Park's (Park et al 2007) work in Korean population found no association between the Ser326Cys polymorphism and colorectal cancer risk.…”